Results 151 to 160 of about 5,280 (176)

The “Matrisome” reveals the characterization of skin keloid microenvironment

The FASEB Journal, 2021
Abstract Keloids are fibroproliferative dermal tumors of unknown origin that are characterized by the overabundant accumulation of extracellular matrix (ECM) components. The mechanism of keloid formation has remained unclear because of a poor understanding of its molecular basis.
Shikun Zhang, Binghui Liu, Wenjuan Wang, Luye Lv, Dunqin Gao, Mi Chai, Mansheng Li, Zhihong Wu, Yunping Zhu, Jie Ma, Ling Leng   +10 more
openaire   +2 more sources

A matrisome atlas of germ cell development

2023
AbstractThe extracellular matrix (matrisome) provides chemical and mechanical cues to control the structure and function of cells and tissues. Yet, comprehensive understanding of how matrisome factors individually and collectively control cell and tissue behaviorin vivois lacking.
Aqilah Amran, Lara Pigatto, Johanna Farley, Rasoul Godini, Roger Pocock, Sandeep Gopal   +5 more
openaire   +1 more source

Senescence-Associated Alterations in Matrisome of Mesenchymal Stem Cells

International Journal of Molecular Sciences
The process of aging is intimately linked to alterations at the tissue and cellular levels. Currently, the role of senescent cells in the tissue microenvironment is still being investigated. Despite common characteristics, different cell populations undergo distinctive morphofunctional changes during senescence.
Andrey Ratushnyy, Ludmila B Buravkova, Diana Matveeva   +2 more
exaly   +3 more sources

The cancer matrisome: From comprehensive characterization to biomarker discovery

Seminars in Cell & Developmental Biology, 2019
Tumor progression and dissemination critically depend on support from the tumor microenvironment, the ensemble of cellular and acellular components surrounding and interacting with tumor cells. The extracellular matrix (ECM), the complex scaffolding of hundreds of proteins organizing cells in tissues, is a major component of the tumor microenvironment.
Alexandra M. Socovich, Alexandra Naba
openaire   +2 more sources

Functional Bioinformatics Analyses of the Matrisome and Integrin Adhesome

2020
The extracellular matrix (ECM) is the noncellular compartment of living organisms and is formed of a complex network of cross-linked proteins, which is collectively known as the matrisome. Apart from providing the structure for an organism, cells interact and thereby communicate with the ECM. Cells interact with their surrounding ECM using cell-surface
openaire   +3 more sources

Dynamic matrisome: ECM remodeling factors licensing cancer progression and metastasis

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2018
The main cause of cancer-related mortality, metastasis, is a complex, multi-step process. The extracellular matrix (ECM) component of solid tumors has been implicated in metastatic progression; however, the ECM exists as a complex macromolecular substrate and it is unclear how its molecular composition promotes cancer progression.
Arseniy E. Yuzhalin, Su Yin Lim, Anton G. Kutikhin, Alex N. Gordon-Weeks   +3 more
openaire   +2 more sources

Beyond the matrisome: New frontiers in ECM research

Matrix Biology, 2023
Suneel S, Apte, Alexandra, Naba
openaire   +2 more sources

Matrisome Expression in the Dorsal Root Ganglion

The Journal of Pain, 2022
Robin Vroman, Zoë Malfait, Rahel Hunter, Anne-Marie Malfait, Fransiska Malfait, Delfien Syx, Rachel Miller   +6 more
openaire   +1 more source

Matrisomic characterization of HCC to inform individualized patient management

Hepatology, 2023
Kanzaki, Hiroaki, Katz, Courtney, Hoshida, Yujin   +2 more
openaire   +2 more sources

The Matrisome Is Associated with Metabolic Reprograming in Stem-like Phenotypes of Gastric Cancer

Cancers, 2022
Ji-Yong Sung, Jae-Ho Cheong
exaly