Results 81 to 90 of about 5,938 (234)

Extracellular matrix and proteolysis: mechanisms driving irreversible changes and shaping cell behavior

The FEBS Journal, EarlyView.
Irreversible ECM proteolysis by remodeling enzymes shapes development, homeostasis, and disease. ECM‐degrading proteases display cell specificity and are governed by shared mechanisms, exhibiting functional redundancy in generating matrikines, growth factors, and cytokines.
Inna Solomonov, Orit Kollet, Irit Sagi
wiley   +1 more source

Matrisome Transcriptome Dynamics during Tissue Aging

Life
The extracellular matrix (ECM) is a complex three-dimensional network of macromolecules that provides structural support for the cells and plays a significant role in tissue homeostasis and repair.
Z. Guvatova, A. Kobelyatskaya, Eveline R. Kudasheva, E. Pudova, E. Bulavkina, A. Churov, O. Tkacheva, A. Moskalev   +7 more
semanticscholar   +1 more source

DOP32 Crohn’s disease stricture matrisome analysis reveals the anti-fibrotic activity of milk-fat globule-epidermal growth factor 8 (MFGE8)

Journal of Crohn's & Colitis, 2023
Intestinal fibrosis is considered an inevitable consequence of chronic inflammatory bowel disease (IBD), leading to stricture formation and need for surgery.
S. Lin, J. Wang, P. Mukherjee, R. Mao, G. West, D. Czarnecki, S. Zhao, M. Elias, Q. Nguyen, J. Chandra, T. H. N. Le, M. Chen, D. Dejanovic, S. Holubar, M. Olman, B. Southern, S. Hu, I. Gordon, K. Atabai, C. Fiocchi, F. Rieder   +20 more
semanticscholar   +1 more source

A guide to building the matrisome interactome: from computational predictions to experimental validation

The FEBS Journal, EarlyView.
This guide proposes a roadmap combining state‐of‐the‐art computational and experimental approaches (including biophysical, biochemical, and imaging techniques) to identify, characterize, and contextualize extracellular matrix (ECM) protein interactions.
Leanna Leverton, Amanpreet Kaur Bains, Ikram Isa, Sylvie Ricard‐Blum, Alexandra Naba   +4 more
wiley   +1 more source

Extracellular Proximity Labeling Reveals an Expanded Interactome for the Matrisome Protein TIMP2

Research Square
Classical methods of investigating protein-protein interactions (PPIs) are generally performed in non-living systems, yet in recent years new technologies utilizing proximity labeling (PL) have given researchers the tools to explore proximal PPIs in ...
David Peeney, Sadeechya Gurung, Joshua Rich, Sasha Coates-Park, Yueqin Liu, Jack Toor, Jane Jones, Christoper Richie, Lisa M. Jenkins, William G. Stetler-Stevenson   +9 more
semanticscholar   +1 more source

The Route to Artery Mimetics: Hybrid Bioinks for Embedded Bioprinting of Multimaterial Cylindrical Models

Advanced Functional Materials, Volume 35, Issue 49, December 2, 2025.
The fabrication of a cellularized, multilayered 3D printed cylindrical model comprising hybrid bioinks inspired by the natural extracellular environment as an approach to artery mimetics, is presented. Using embedded bioprinting, interlayer crosslinking of self‐supporting concentric cylinders is achieved.
Uxue Aizarna‐Lopetegui, Ada Herrero‐Ruiz, Monize C. Decarli, Ane Urigoitia‐Asua, Karla Chavarri‐Urraca, Lorenzo Moroni, Malou Henriksen‐Lacey, Dorleta Jimenez de Aberasturi   +7 more
wiley   +1 more source

EPB41L5 controls podocyte extracellular matrix assembly by adhesome-dependent force transmission

Cell Reports, 2021
Summary: The integrity of the kidney filtration barrier essentially relies on the balanced interplay of podocytes and the glomerular basement membrane (GBM).
Jasmin I. Maier, Manuel Rogg, Martin Helmstädter, Alena Sammarco, Oliver Schilling, Benedikt Sabass, Jeffrey H. Miner, Jörn Dengjel, Gerd Walz, Martin Werner, Tobias B. Huber, Christoph Schell   +11 more
doaj   +1 more source

The functional logic of corticostriatal connections [PDF]

, 2016
Unidirectional connections from the cortex to the matrix of the corpus striatum initiate the cortico-basal ganglia (BG)-thalamocortical loop, thought to be important in momentary action selection and in longer-term fine tuning of behavioural repertoire ...
Shipp, S
core   +1 more source

Chemoselective Characterization of New Extracellular Matrix Deposition in Bioengineered Tumor Tissues

Advanced Materials, Volume 37, Issue 47, November 27, 2025.
Understanding the bi‐directional crosstalk between cells and their surrounding extracellular matrix (ECM) is critical for tissue engineering. This study presents a chemoselective strategy for proteomic profiling of newly deposited ECM from resident cells.
Zihan Ling, Burke Niego, Qingyang Li, Dhruv Bhattaram, Vanessa Serna Villa, Michael Hu, Zhuowei Gong, Lloyd M. Smith, Brian L. Frey, Xi Ren   +9 more
wiley   +1 more source

Mmp14 is required for matrisome homeostasis and circadian rhythm in fibroblasts

bioRxiv, 2023
The circadian clock in tendon regulates the daily rhythmic synthesis of collagen-I and the appearance and disappearance of small-diameter collagen fibrils in the extracellular matrix.
Ching-Yan Chloé Yeung, Richa Garva, A. Pickard, Yinhui Lu, V. Mallikarjun, J. Swift, Susan H. Taylor, J. Rai, D. Eyre, M. Chaturvedi, Y. Itoh, Q. Meng, C. Mauch, P. Zigrino, K. Kadler   +14 more
semanticscholar   +1 more source