Results 81 to 90 of about 5,313 (152)

Thermo‐Chemically Modified Silk Scaffolds Reveal Niche‐Driven Regulation of Hematopoiesis and Fibrosis

Small, EarlyView.
We introduce a versatile 3D platform that recreates key physical and biological features of the human bone marrow. By integrating tunable silk biomaterials, stromal cells, and human hematopoietic progenitors, the model captures both healthy and diseased microenvironments, analysis of blood formation, and its disruption in pathological conditions ...
Christian A. Di Buduo, Carolina P. Miguel, Giulia Della Rosa, Vittorio Abbonante, Santo Diprima, Delfina Tosi, Marta Filibian, Daniele Cattaneo, Jugal Kishore Sahoo, Nicola Tirelli, Alessandra Iurlo, Umberto Gianelli, David L. Kaplan, Alessandra Balduini   +13 more
wiley   +1 more source

RGTA® or ReGeneraTing Agents mimic heparan sulfate in regenerative medicine: from concept to curing patients [PDF]

, 2017
The importance of extracellular matrix (ECM) integrity in maintaining normal tissue function is highlighted by numerous pathologies and situations of acute and chronic injury associated with dysregulation or destruction of ECM components. Heparan sulfate
Barritault, D. (Denis), Baudouin, C. (Christophe), Desgranges, P. (Pascal), Gilbert-Sirieix, M. (Marie), Neck, J.W. (Han) van, Papy-Garcia, D. (Dulce), Rice, K.L. (Kim Lee), Saffar, J.-L. (Jean-Louis), Siñeriz, F. (Fernando), Zakine, G. (Gilbert)   +9 more
core   +2 more sources

Machine Learning Reveals the Association Between Gene Expression and Immune Infiltration in Colorectal Cancer: A Comprehensive Study From Single‐Cell to Survival Analysis

Journal of Cellular and Molecular Medicine, Volume 30, Issue 5, March 2026.
ABSTRACT Colorectal cancer (CRC) is one of the most common causes of cancer mortality globally. Analysis of immune cell infiltration patterns in the tumour microenvironment (TME) is critical to treatment outcomes, but the molecular mechanisms which regulate this process are still poorly understood.
Xiaoxin Duan, Shen Huang, Yan Zhou, Tao Yang, Jiaqi Liu, Hudan Song, Pingliang Sun   +6 more
wiley   +1 more source

A novel histone deacetylase inhibitor W2A-16 improves the barrier integrity in brain vascular endothelial cells

Frontiers in Cellular Neuroscience
The maturation of brain microvascular endothelial cells leads to the formation of a tightly sealed monolayer, known as the blood–brain barrier (BBB). The BBB damage is associated with the pathogenesis of age-related neurodegenerative diseases including ...
Yasuteru Inoue, Yingxue Ren, Shuwen Zhang, Michael Bamkole, Naeyma N. Islam, Manikandan Selvaraj, Wenyan Lu, Wenyan Lu, Thomas R. Caulfield, Yonghe Li, Takahisa Kanekiyo, Takahisa Kanekiyo   +11 more
doaj   +1 more source

The extracellular matrix phenome across species

Matrix Biology Plus, 2020
Extracellular matrices are essential for cellular and organismal function. Recent genome-wide and phenome-wide association studies started to reveal a broad spectrum of phenotypes associated with genetic variants.
Cyril Statzer, Collin Y. Ewald
doaj   +1 more source

Cell-selective labeling using amino acid precursors for proteomic studies of multicellular environments. [PDF]

, 2013
We report a technique to selectively and continuously label the proteomes of individual cell types in coculture, named cell type-specific labeling using amino acid precursors (CTAP).
A Naba, A Shevchenko, A Subramanian, AF Olumi, AL Szymczak, B Macek, Boris Macek, Boumediene Soufi, C Jørgensen, CC Liu, Chris Sander, David Y Gin, DS Spellman, DW Mcmillin, F Truong, G-JCM van den Bemd, H Xu, J Cox, J Cox, J Jouanneau, JA Joyce, JT Ngo, JT Ngo, JV Olsen, KJ Mavrakis, KM Saqib, Konstantinos J Mavrakis, Martin L Miller, MD Sury, Nicholas P Gauthier, O Rechavi, PL Ross, S Swift, S-E Ong, S-E Ong, SP Gygi, T Geiger, V Nanduri, Virginia A Pedicord, William E Walkowicz, Y Benjamini, Y Ishihama, Y-C Kuan   +42 more
core   +1 more source

The extracellular matrix component perlecan/HSPG2 regulates radioresistance in prostate cancer cells

Frontiers in Cell and Developmental Biology
Radiotherapy of prostate cancer (PC) can lead to the acquisition of radioresistance through molecular mechanisms that involve, in part, cell adhesion-mediated signaling.
Ivana Samaržija, Ivana Samaržija, Vasyl Lukiyanchuk, Marija Lončarić, Anja Rac-Justament, Nikolina Stojanović, Ielizaveta Gorodetska, Uğur Kahya, Uğur Kahya, Jonathan D. Humphries, Mahak Fatima, Martin J. Humphries, Ana Fröbe, Anna Dubrovska, Anna Dubrovska, Anna Dubrovska, Anna Dubrovska, Anna Dubrovska, Andreja Ambriović-Ristov   +18 more
doaj   +1 more source

Bioinspired Tissue Transparency: Achieving Sclera‐to‐Cornea Transplantation

Advanced Science, Volume 13, Issue 10, 18 February 2026.
A bioinspired decellularization‐compression‐locking tactic (DCLT) is developed to transform human sclerae into transparent corneal substitutes. These clear, robust, and pro‐regenerative substitutes are capable of repairing complex corneal injuries, including chemical burns, keratoconus, and penetrating wounds, demonstrating their clinical potential to ...
Xiuli Sun, Long Zhao, Zhen Shi, Jingting Wang, Shang Yang, Xia Qi, Hengrui Zhang, Ting Wang, Weiyun Shi   +8 more
wiley   +1 more source

Avian Primordial Germ Cells Contribute to and Interact With the Extracellular Matrix During Early Migration

Frontiers in Cell and Developmental Biology, 2019
During early avian development, primordial germ cells (PGC) are highly migratory, moving from the central area pellucida of the blastoderm to the anterior extra-embryonic germinal crescent.
David J. Huss, David J. Huss, Sasha Saias, Sevag Hamamah, Jennifer M. Singh, Jennifer M. Singh, Jinhui Wang, Jinhui Wang, Mohit Dave, Junhyong Kim, Junhyong Kim, James Eberwine, James Eberwine, Rusty Lansford, Rusty Lansford   +14 more
doaj   +1 more source

Proteomic analysis of decellularized mice liver and kidney extracellular matrices

Journal of Biological Engineering
Background The extracellular matrix (ECM) is a three-dimensional network of proteins that encases and supports cells within a tissue and promotes physiological and pathological cellular differentiation and functionality.
Anna-Maria Diedrich, Assal Daneshgar, Peter Tang, Oliver Klein, Annika Mohr, Olachi A. Onwuegbuchulam, Sabine von Rueden, Kerstin Menck, Annalen Bleckmann, Mazen A. Juratli, Felix Becker, Igor M. Sauer, Karl H. Hillebrandt, Andreas Pascher, Benjamin Struecker   +14 more
doaj   +1 more source