Results 91 to 100 of about 81,093 (306)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Periodic review base-stock replenishment policy with endogenous lead times. [PDF]

In this paper, we consider a two stage supply chain where the retailer's inventory is controlled by the periodic review, base-stock level (R,S) replenishment policy and the replenishment lead times are endogenously generated by the manufacturer's ...
Boute, Robert, Lambrecht, Marc, Van Houdt, B   +2 more
core  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Matrix-Analytic Methods in Queueing Theory

, 2015
Analytical methods for tractable (Markov) queueing models commonly assume Poisson arrivals and exponential service. The assumptions are unrealistic from a modeling point of view.
Huang, Anqi
core  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Matrix-analytic methods in supply chain management: recent developments

, 2012
Matrix-analytic methods are a popular modeling tool in a great number of fields, most notable in the analysis of telecommunication systems. Because of their ability to construct and analyze a wide class of stochastic mod els, they can also be applied in ...
Creemers, S., Noblesse, Ann, Boute, Robert, Colen, P., Van Houdt, Benny, Noblesse, A., Colen, Pieter, Van Houdt, B., Boute, R., Creemers, Stefan   +9 more
core  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

PraFL: A Single-Round Analytic Paradigm for Privacy-Preserving and Heterogeneity-Robust Federated Learning

IEEE Access
The exponential proliferation of edge-generated data necessitates robust Federated Learning (FL) frameworks, yet statistical heterogeneity and severe data scarcity in decentralized environments persistently compromise model generalization and exacerbate ...
Wang Lei, Jasni Mohamad Zain, Nur Atiqah Sia Abdullah, Md. Arafatur Rahman, Hai Tao, Ali H. Alenezi   +5 more
doaj   +1 more source

Solving the Least Squares Method problem in the AHP for 3 X 3 and 4 X 4 matrices

, 2005
The Analytic Hierarchy Process (AHP) is one of the most popular methods used in Multi-Attribute Decision Making. The Eigenvector Method (EM) and some distance minimizing methods such as the Least Squares Method (LSM) are of the possible tools for ...
Bozóki, Sándor
core  

Advances of matrix–analytic methods in risk modelling [PDF]

, 2019
This work is concerned with the study of matrix–analytic methods with novel applications to the area of risk theory. First, we review some topics of Applied Probability such as phase–type distributions, matrix–exponential distributions, Markovian arrival
Peralta Gutierrez, Oscar
core