Results 101 to 110 of about 81,093 (306)
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
A defect recognition method based on ITLPP and multi-feature fusion matrix
Scientific ReportsThe recognition of defects is a critical component in monitoring the structural integrity of metal components. Accurate discrimination between surface and subsurface defects is crucial for assessing the structural safety of metal components, yet remains ...
Biting Lei, Pengxing Yi
doaj +1 more source
Applications of Lie methods to computations with polycyclic groups
, 2008 In this thesis we demonstrate the algorithmic usefulness of the so-called Mal'cev correspondence for computations with infinite polycyclic groups.
Assmann, Björn
core
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
The Development of Methods to Estimate and Reduce Design Rework [PDF]
, 2012 Design rework includes unnecessary repetition in design tasks to correct design problems. Resolving design matters in advance, through in-depth understanding of the design planning and rework issues and development of effective predictive tools could ...
Arundachawat, Panumas
core
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Using the three-way matrix for AHP-group decision-making
Ratio MathematicaThe Analytic Hierarchy Process (AHP) is one of the most well-known and used multi-criteria methods in the field of decision problems. In many situations, the decision is not up to a single person but involves multiple decision-makers with different ...
Elisa Fiorenza
doaj +1 more source
A matrix-geometric solution for the multiserver nonpreemptive priority queueing model with mixed priorities. [PDF]
This paper describes the analysis of multiserver queues with nonpreemptive mixed priorities. Such priority structures occur, for example, in initiator settings within the mainframe operating system MVS: job classes have to be assigned to initiators and ...
Leemans, Herlinde, Dedene, Guido
core
Analytic nonintegrability and S-matrix factorization
, 2021 We formulate an equivalence between the 2-dim s-model spectrum expanded on a nontrivial massive vacuum and a classical particle Hamiltonian with variable mass and potential. By considering methods of analytic Galoisian nonintegrability on the appropriate
Giataganas, Dimitrios
core
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source