Results 91 to 100 of about 812,204 (311)

Integrity of Narrow Epithelial Tubes in the C. elegans Excretory System Requires a Transient Luminal Matrix.

PLoS Genetics, 2016
Most epithelial cells secrete a glycoprotein-rich apical extracellular matrix that can have diverse but still poorly understood roles in development and physiology.
Hasreet K Gill, Jennifer D Cohen, Jesus Ayala-Figueroa, Rachel Forman-Rubinsky, Corey Poggioli, Kevin Bickard, Jean M Parry, Pu Pu, David H Hall, Meera V Sundaram   +9 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Localized boundary-domain singular integral equations based on harmonic parametrix for divergence-form elliptic PDEs with variable matrix coefficients

, 2013
This is the post-print version of the Article. The official publised version can be accessed from the links below. Copyright @ 2013 Springer BaselEmploying the localized integral potentials associated with the Laplace operator, the Dirichlet, Neumann and
Mikhailov, SE, Natroshvili, D, Chkadua, O   +2 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Enhanced antiangiogenic therapy with antibody‐collagen XVIII NC1 domain fusion proteins engineered to exploit matrix remodeling events

, 2006
Antiangiogenic therapy is nowadays one of the most active fields in cancer research. The first strategies, aimed at inhibiting tumor vascularization, included upregulation of endogenous inhibitors and blocking of the signals delivered by angiogenic ...
Álvarez‐Vallina, Luis, Víctor J. Sánchez‐Arévalo Lobo, Francisco J. Blanco, Prieto, Jesús, Blanco, Francisco, Laura Sanz, Compte, Marta, García, Pascal, Jesús Prieto, Cuesta Martínez, Ángel, Ángel M. Cuesta, Sanz, Laura, Sánchez‐Arévalo Lobo, Víctor J., Pascal García, Marta Compte, Luis Álvarez‐Vallina   +15 more
core   +1 more source

Application of multisection recursive convolution in 3D FETD-FABC simulations [PDF]

, 2008
The multisection recursive convolution (MS-RC) methodology is successfully applied to the finite element time domain floquet absorbing boundary condition modeling of doubly periodic structures.
Cai, Yong, Yong Cai, Christos Mias, Mias, Christos   +3 more
core   +1 more source

Image Steganalysis in Frequency Domain Using Co-Occurrence Matrix and Bpnn

Science Journal of University of Zakho, 2019
In the last two decades, steganalysis has become a fertile research area to minimize the security risks left behind by Misuse of data concealment in digital computer files.
Isamadeen A. Khalifa, Subhi R.M. Zeebaree, Musa Ataş, Farhad M. Khalifa   +3 more
doaj   +1 more source

Hierarchical matrix techniques for a domain decomposition algorithm [PDF]

Computing, 2007
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Functional studies of matrix metalloproteinases (MMP14, 15, 16) in animal and cell culture models

, 2003
Li H. Functional studies of matrix metalloproteinases (MMP14, 15, 16) in animal and cell culture models. Bielefeld (Germany): Bielefeld University; 2003.It has been known, MT1-, 2-, 3-, 5-MMP have a transmembrane (TM) domain and MT4-, 6-MMP contain a GPI
Li, Hongbin
core