Results 71 to 80 of about 3,348,378 (252)
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Almost convergent sequence spaces derived by the domain of quadruple band matrix
Annales Universitatis Paedagogicae Cracoviensis: Studia Mathematica, 2020 In this work, we construct the sequence spaces f(Q(r,s,t,u)), f0(Q(r,s,t,u)) and fs(Q(r,s,t,u)), where Q(r,s,t,u) is quadruple band matrix which generalizes the matrices Δ3, B(r,s,t), Δ2, B(r,s) and Δ, where Δ3, B(r,s,t), Δ2, B(r,s) and Δ are called ...
Mustafa Cemil Bişgin
doaj
Journal of Orthopaedic Surgery and Research, 2008 The von Willebrand Factor A (vWF A) domain is one of the most widely distributed structural modules in cell-matrix adhesive molecules such as intergrins and extracellular matrix proteins.
Kanbe Katsuaki +4 more
doaj +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Shock and Vibration, 1993 A procedure for generating vectors of time domain signals that are partially coherent in a prescribed manner is described. The procedure starts with the spectral density matrix, [Gxx(f)] , that relates pairs of elements of the vector random process {X(t)}
David O. Smallwood, Thomas L. Paez
doaj +1 more source
A class of alternate strip-based domain decomposition methods for elliptic partial differential Equations [PDF]
, 2005 The domain decomposition strategies proposed in this thesis are efficient preconditioning techniques with good parallelism properties for the discrete systems which arise from the finite element approximation of symmetric elliptic boundary value problems
Mihai, Loredana Angela
core
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
RECENT RESULTS ON THE DOMAIN OF THE SOME LIMITATION METHODS IN THE SEQUENCE SPACES f0 AND f
Journal of New Theory, 2015 − In the present paper, we summarize the literature on the sequence spaces almost A−nulland almost A−convergent derived by using the domain of the certain A− limitation matrix.
Serkan Demiriz
doaj