Results 71 to 80 of about 812,204 (311)

Tissue Localization and Extracellular Matrix Degradation by PI, PII and PIII Snake Venom Metalloproteinases: Clues on the Mechanisms of Venom-Induced Hemorrhage [PDF]

open access: yes, 2015
20 páginas, 4 figuras, 3 tablas y 7 tablas en material suplementario.Snake venom hemorrhagic metalloproteinases (SVMPs) of the PI, PII and PIII classes were compared in terms of tissue localization and their ability to hydrolyze basement membrane ...
Calvete, JJ   +47 more
core   +1 more source

Scatter Matrix Based Domain Adaptation for Bi-Temporal Polarimetric SAR Images

open access: yesRemote Sensing, 2020
Time series analysis (TSA) based on multi-temporal polarimetric synthetic aperture radar (PolSAR) images can deeply mine the scattering characteristics of objects in different stages and improve the interpretation effect, or help to extract the range of ...
Weidong Sun   +6 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

open access: yesMolecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel   +6 more
wiley   +1 more source

Fibronectin III 13-14 Domains Induce Joint Damage via Toll-Like Receptor 4 Activation and Synergize with Interleukin-1 and Tumour Necrosis Factor

open access: yes, 2011
Cartilage loss is a feature of chronic arthritis. It results from degradation of the extracellular matrix which is composed predominantly of aggrecan and type II collagen.
Saralili Dipa Robertson   +6 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

Matrix metalloproteinases at key junctions in the pathomechanism of stroke

open access: yes, 2011
Matrix metalloproteinases play a crucial role in the remodelling of the extracellular matrix through direct degradation of its structural proteins and control of extracellular signaling.
Kolev, Kraszimir   +5 more
core   +1 more source

The Complex Domain Matrix of Ditransitive Constructions

open access: yes, 2022
This study focuses on the semantics of ditransitive constructions. Its main aim is to show that the semantics of this type of construction is made up of elements belonging to different conceptual domains. In order to fully analyze the complexity inherent
Unternbäumen, Enrique Huelva
core   +1 more source

Multiple functions of the von Willebrand Factor A domain in matrilins: secretion, assembly, and proteolysis

open access: yesJournal of Orthopaedic Surgery and Research, 2008
The von Willebrand Factor A (vWF A) domain is one of the most widely distributed structural modules in cell-matrix adhesive molecules such as intergrins and extracellular matrix proteins.
Kanbe Katsuaki   +4 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Domain boundary engineering

open access: yes
We review the idea that domain boundaries, rather than domains, can carry information and act as memory devices. Domains are bulk objects; their large response to changing external fields is related to their change in volume, which implies the movement ...
Salje, E. K. H., Zhang, H. L.
core   +1 more source

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