Results 61 to 70 of about 794,000 (393)

Common matrix metalloproteinase-2 gene variants and altered susceptibility to breast cancer and associated features in Tunisian women

Tumor Biology, 2019
A role for matrix metalloproteinase polymorphisms in breast cancer development and progression was proposed, but with inconclusive results. We assessed the relation of matrix metalloproteinase-2 variants with breast cancer and related phenotypes in ...
Azza F Habel, Rabeb M Ghali, Hanen Bouaziz, Amira Daldoul, Mariem Hadj-Ahmed, Amina Mokrani, Sonia Zaied, Monia Hechiche, Khaled Rahal, Besma Yacoubi-Loueslati, Wassim Y Almawi   +10 more
doaj   +1 more source

Selective function-blocking monoclonal human antibody highlights the important role of membrane type-1 matrix metalloproteinase (MT1-MMP) in metastasis. [PDF]

, 2016
The invasion-promoting MT1-MMP is a cell surface-associated collagenase with a plethora of critical cellular functions. There is a consensus that MT1-MMP is a key protease in aberrant pericellular proteolysis in migrating cancer cells and, accordingly, a
Cieplak, Piotr, Ge, Xin, Nam, Dong Hyun, Remacle, Albert G, Shiryaev, Sergey A, Strongin, Alex Y   +5 more
core   +1 more source

Matrix Metalloproteinase-2 Gene Polymorphisms in Nasal Polyps [PDF]

Archives of Otolaryngology–Head & Neck Surgery, 2008
To systematically investigate the role of matrix metalloproteinase-2 (MMP2) tagging single nucleotide polymorphisms (SNPs) and promoter functional polymorphism in the development of nasal polyps in a Chinese population in Taiwan.We conducted a case-control study in 136 cases of chronic rhinosinusitis with bilateral nasal polyps and 136 controls ...
Ling-Feng, Wang, Chen-Yu, Chien, Wen-Rei, Kuo, Chin-Feng, Tai, Suh-Hang Hank, Juo   +4 more
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Kallikrein‐1 Blockade Inhibits Aortic Expansion in a Mouse Model and Reduces Prostaglandin E2 Secretion From Human Aortic Aneurysm Explants

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Abdominal aortic aneurysm (AAA) is an important cause of mortality in older adults. The kinin B2 receptor agonist, bradykinin, has been implicated in AAA pathogenesis through promoting inflammation.
Corey S. Moran, Erik Biros, Smriti M. Krishna, Susan K. Morton, Daniel J. Sexton, Jonathan Golledge   +5 more
doaj   +1 more source

Inhibitory antibodies designed for matrix metalloproteinase modulation [PDF]

, 2019
The family of matrix metalloproteinases (MMPs) consists of a set of biological targets that are involved in a multitude of severe pathogenic events such as different forms of cancers or arthritis.
Fischer, Thomas, Riedl, Rainer
core   +1 more source

Matrix metalloproteinase-2 activation modulates glioma cell migration [PDF]

Journal of Cell Science, 1997
ABSTRACT Stable transfection of U251.3 glioma cells with cDNA encoding MT-MMP-1 resulted in increased cell surface expression of MT-MMP-1 and TIMP-2, constitutive activation of MMP-2 proenzyme and increased collagen degradation. In tumor spheroid outgrowth assays, cell migration of MT-MMP-1 transfectants relative to control was enhanced ...
Deryugina, E I, Bourdon, M A, Luo, G X, Reisfeld, R A, Strongin, A   +4 more
openaire   +4 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Identification of matrix metalloproteinase-2 and -9 activities within the intestinal mucosa of dogs with chronic enteropathies

Acta Veterinaria Scandinavica, 2018
Background Matrix metalloproteinases (MMPs) 2 and 9 are zinc- and calcium-dependent endopeptidases involved in the breakdown and reconstitution of extracellular matrix under both physiological and pathological conditions.
Mohsen Hanifeh, Minna Marjaana Rajamäki, Pernilla Syrjä, Laura Mäkitalo, Susanne Kilpinen, Thomas Spillmann   +5 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source