Results 261 to 270 of about 240,479 (306)

Spontaneous metastasis in matrix metalloproteinase 3‐deficient mice

Molecular Carcinogenesis, 2008
AbstractMatrix metalloproteinases (MMPs) have been linked to the metastatic potential of tumor cells due to their ability to degrade the extracellular matrix. MMP‐3 (stromelysin‐1) is upregulated in a wide variety of human tumors. We used the MMTV‐PyMT breast cancer model to determine if MMP‐3 is involved in tumorigenesis and metastatic growth. In this
Juncker-Jensen, Anna, Rømer, John, Pennington, Caroline J, Lund, Leif R, Almholt, Kasper   +4 more
openaire   +3 more sources

Matrix Metalloproteinase-3 induces proteoglycan degradation in gouty arthritis model

Gene, 2021
Gout is an inflammatory arthritis resulting from precipitation of monosodium urate (MSU) crystals in joints and surrounding tissues. However, the mechanism underlying high levels of uric acid inducing gouty arthritis has not been clarified.The purpose was to investigate the role of Matrix Metalloproteinase-3 (MMP-3) in the development of gouty ...
Le Shi, Tao Liang, Fan Yang, Fang-Fang Zhu, Jin Liu, Jia-Qian Jiang, Xiao-Wei Wu, An-Sheng Chen, Dong-Ping Yuan, Xin-Li Liang   +9 more
openaire   +2 more sources

The importance of matrix metalloproteinase-3 in respiratory disorders

Expert Review of Respiratory Medicine, 2014
The matrix metalloproteinases (MMPs) encompass a family of zinc-dependent endopeptidases that are secreted into the extracellular environment or remain bound to the cell surface. While MMPs were initially identified based on their ability to degrade collagen and other components of the extracellular matrix, recent studies indicate that their non ...
Cory M, Yamashita, Derek C, Radisky, Yael, Aschner, Gregory P, Downey   +3 more
openaire   +2 more sources

Matrix Metalloproteinase-3 Production by Human Degenerated Intervertebral Disc

Journal of SPINAL DISORDERS, 1997
To assess its possible role in the pathophysiology of intervertebral disc degeneration, we investigated the production of matrix metalloproteinase-3 (MMP-3) using human intervertebral disc explant culture. Five normal and 10 degenerated disc specimens were used. The levels of MMP-3 released in the medium were measured with use of an enzyme immunoassay.
O, Nemoto, M, Yamagishi, H, Yamada, T, Kikuchi, H, Takaishi   +4 more
openaire   +2 more sources

Matrix Metalloproteinase-3 Differences in Oral and Skin Fibroblasts

Journal of Dental Research, 2007
While skin wounds heal by scarring, wounds of oral mucosa show privileged healing with minimal scar formation. Our hypothesis was that phenotypic differences between oral and skin fibroblasts underlie these differences in healing. The aims of this study were to compare MMP-3 expression by oral and skin fibroblasts and investigate a role for MMP-3 in ...
S T W, McKeown, J J, Barnes, P L, Hyland, F T, Lundy, M J, Fray, C R, Irwin   +5 more
openaire   +2 more sources

Serum levels of matrix metalloproteinase‐3 in undifferentiated spondyloarthropathy

Scandinavian Journal of Rheumatology, 2007
Spondyloarthropathy (SpA) is a family of chronic arthritis, characterized by inflammatory back pain, peripheral arthritis, and enthesitis [1].
C-H, Chen, H-T, Liao, H-A, Chen, T-H, Liang, H-P, Wang, C-T, Chou   +5 more
openaire   +2 more sources

Structure of matrix metalloproteinase-3 with a platinum-based inhibitor

Chemical Communications, 2013
An X-ray investigation has been performed with the aim of characterizing the binding sites of a platinum-based inhibitor (K[PtCl3(DMSO)]) of matrix metalloproteinase-3 (stromelysin-1). The platinum complex targets His224 in the S1' specificity loop, representing the first step in the selective inhibition process (PDB ID code 4JA1).
Belviso Benny Danilo, Caliandro Rocco, Siliqi Dritan, Calderone Vito, Arnesano Fabio, Natile Giovanni   +5 more
openaire   +7 more sources

Tissue inhibitor of metalloproteinases‐3 and matrix metalloproteinase‐3 regulate neuronal sensitivity to doxorubicin‐induced apoptosis

European Journal of Neuroscience, 2003
AbstractMetalloproteinase activity at the cell surface influences cellular sensitivity to extrinsic death vs. survival signals in a variety of cell types, through proteolytic shedding of cell surface signalling molecules. Tissue inhibitor of metalloproteinases‐3 (TIMP‐3) is a unique natural metalloproteinase inhibitor that plays a pro‐apoptotic role ...
M, Wetzel, G A, Rosenberg, L A, Cunningham   +2 more
openaire   +2 more sources

Abstract 370: Matrix Metalloproteinase-3 Regulates Arterial Calcification

Arteriosclerosis, Thrombosis, and Vascular Biology, 2016
Objective: Medial artery calcification is associated with increased cardiovascular morbidity and mortality in patients with peripheral artery disease (PAD). It is highly prevalent in diabetes and chronic kidney disease, and it is an important risk factor for cardiovascular events.
Tonghui Lin, Xue-lin Wang, Yujun Cai, Sara L Zettervall, Raul J Guzman   +4 more
openaire   +1 more source

Matrix Metalloproteinase-3 on Ligamentum Flavum in Degenerative Lumbar Spondylolisthesis

Spine, 2009
Human ligamentum flavum (LF) was examined for the activity level of matrix metalloproteinase-3 (MMP-3) in degenerative spondylolithesis (DS) patients using immunohistochemistry, Western blot, reverse transcriptase-polymerase chain reaction (RT-PCR), and quantitative real-time PCR.To investigate the hypothesis that the activity of MMP-3 is elevated in ...
In-Soo, Oh, Kee-Yong, Ha
openaire   +2 more sources