Results 41 to 50 of about 233,826 (312)

Ras, metastasis, and matrix metalloproteinase 9

, 2001
Publisher Summary This chapter describes the Ras, metastasis, and matrix metalloproteinase 9. The process of metastasis involves breakdown and penetration of intercellular matrix and basement membranes. The basement membrane in particular is a barrier to tumor invasion, intravasation, and extravasation.
Bernhard, E, Muschel, R
openaire   +3 more sources

Prospective study of matrix metalloproteinase-9 and risk of myocardial infarction and stroke in older men and women

, 2009
OBJECTIVES: The endopeptidase matrix metalloproteinase-9 (MMP-9) is implicated in atherosclerotic plaque rupture. We investigate prospective associations between MMP-9 and MI or stroke in an older general population cohort, accounting for established and
Lowe, Gordon, Welsh, P, Thomson, A., Jefferis, B. J., Lennon, L., Lowe, G., Ebrahim, S, Carson, Claire, Jefferis, B.J., Welsh, Paul, Rumley, A., Ebrahim, S., Ebrahim, Shah, Jefferis, Barbara J, Lawlor, Debbie, Jefferis, BJ, Welsh, P., Whincup, Peter, Wannamethee, G, Lawlor, D., Lawlor, D, Wannamethee, G., Rumley, Ann, Whincup, P., Whincup, P, Thomson, Andy, Jefferis, Barbara J., Thomson, A, Lennon, Lucy, Wannamethee, Goya, Carson, C., Rumley, A, Lennon, L, Carson, C, Lowe, G   +34 more
core   +1 more source

Chitinase-3 like-protein-1, matrix metalloproteinase -9 and positive intracranial arterial remodelling

Frontiers in Aging Neuroscience, 2023
IntroductionPositive intracranial arterial remodelling is a dilated lesion of the large intracranial vessels; however, its pathogenesis is currently unknown.
Ming Tang, Dongyang Zhou, Junhui He, Hongying Bai, Qianqian Li, Hui Xu   +5 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Amelioration of Pulmonary Fibrosis by Matrix Metalloproteinase-2 Overexpression [PDF]

, 2023
三重大学博士(医学)application/pdfIdiopathic pulmonary fibrosis is a progressive and fatal disease with a poor prognosis.Matrix metalloproteinase-2 is involved in the pathogenesis of organ fibrosis.
井上, 亮, Inoue, Ryo, イノウエ, リョウ   +2 more
core   +1 more source

Assessment of Matrix Metalloproteinases a Prognostic Indicator in Advanced Fibrotic Lung Disease: A Systematic Review

Pakistan Journal of Medicine and Dentistry
Background: Fibrotic lung diseases were seen to have devastating effects among patients globally. Matrix metalloproteinases (MMP) including MMP-7, MMP-9, and MMP-1 have become promising biomarkers for idiopathic pulmonary fibrosis (IPF), and other ...
Mehvish Aqil, Saif Ur Rahman, Muhammad Zeeshan Aslam, Mostafa Ahmed Abdellah Ahmed, Ammar Ahmed, Sidra Javaid, Ehsan Ul Haq   +6 more
doaj   +1 more source

Asthma remodeling: The pathogenic role of matrix metalloproteinase-9

Egyptian Journal of Chest Disease and Tuberculosis, 2014
Background: Asthma is an airway inflammatory disease with functional and structural changes, leading to bronchial hyperresponsiveness and airflow obstruction.
Amgad A. Farhat, Ahmad S. Mohamad, Mohamad M. Shareef, Ghada Atef Attia, Manal A. Eid, Rehab W. Taha   +5 more
doaj   +1 more source

Matrix metalloproteinase 9 gene-MMP9-DNA methylation status in Turkish schizophrenia patients

Türk Biyokimya Dergisi, 2023
Schizophrenia is a neuropsychiatric disease caused by disorders in brain development due to genetic and environmental factors. The interactions and mechanisms of the two main etiological factors are not fully understood despite neurobiological, clinical ...
Karaaslan Ezgi, Kartalci Şükrü, Bağ Harika Gözde Gözükara, Acar Ceren   +3 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Matrix metalloproteinases at key junctions in the pathomechanism of stroke

, 2011
Matrix metalloproteinases play a crucial role in the remodelling of the extracellular matrix through direct degradation of its structural proteins and control of extracellular signaling.
Kolev, Kraszimir, Kolev Krasimir, Rottenberger Zsolt, Zsolt Rottenberger, Rottenberger, Zsolt, Krasimir Kolev   +5 more
core   +1 more source