Results 61 to 70 of about 237,619 (312)

Ras, metastasis, and matrix metalloproteinase 9

, 2001
Publisher Summary This chapter describes the Ras, metastasis, and matrix metalloproteinase 9. The process of metastasis involves breakdown and penetration of intercellular matrix and basement membranes. The basement membrane in particular is a barrier to tumor invasion, intravasation, and extravasation.
Bernhard, E, Muschel, R
openaire   +3 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Assessment of Matrix Metalloproteinases a Prognostic Indicator in Advanced Fibrotic Lung Disease: A Systematic Review

Pakistan Journal of Medicine and Dentistry
Background: Fibrotic lung diseases were seen to have devastating effects among patients globally. Matrix metalloproteinases (MMP) including MMP-7, MMP-9, and MMP-1 have become promising biomarkers for idiopathic pulmonary fibrosis (IPF), and other ...
Mehvish Aqil, Saif Ur Rahman, Muhammad Zeeshan Aslam, Mostafa Ahmed Abdellah Ahmed, Ammar Ahmed, Sidra Javaid, Ehsan Ul Haq   +6 more
doaj   +1 more source

Asthma remodeling: The pathogenic role of matrix metalloproteinase-9

Egyptian Journal of Chest Disease and Tuberculosis, 2014
Background: Asthma is an airway inflammatory disease with functional and structural changes, leading to bronchial hyperresponsiveness and airflow obstruction.
Amgad A. Farhat, Ahmad S. Mohamad, Mohamad M. Shareef, Ghada Atef Attia, Manal A. Eid, Rehab W. Taha   +5 more
doaj   +1 more source

Matrix metalloproteinase 9 gene-MMP9-DNA methylation status in Turkish schizophrenia patients

Türk Biyokimya Dergisi, 2023
Schizophrenia is a neuropsychiatric disease caused by disorders in brain development due to genetic and environmental factors. The interactions and mechanisms of the two main etiological factors are not fully understood despite neurobiological, clinical ...
Karaaslan Ezgi, Kartalci Şükrü, Bağ Harika Gözde Gözükara, Acar Ceren   +3 more
doaj   +1 more source

Matrix Metalloproteinase-9 () polymorphisms in patients with cutaneous malignant melanoma [PDF]

, 2007
Background Cutaneous Malignant Melanoma causes over 75% of skin cancer-related deaths, and it is clear that many factors may contribute to the outcome.
Javier Cotignola, Boris Reva, Nandita Mitra, Nicole Ishill, Shaokun Chuai, Ami Patel, Shivang Shah, Gretchen Vanderbeek, Daniel Coit, Klaus Busam, Allan Halpern, Alan Houghton, Chris Sander, Marianne Berwick, Irene Orlow, A Jemal, LJ McCawley, S Pasco, SC Liu, H Islekel, W Zhao, YG Shellman, JJ van den Oord, UB Hofmann, MD Corte, J Nikkola, S Zucker, K Jung, GS Makowski, PE Van den Steen, RC Millikan, J Gough, CD Bennett, M Ronaghi, M Franchina, PJ Oefner, I Orlow, PD Sasieni, EL Kaplan, L Excoffier, JH Zhao, DJ Schaid, DG Peters, S Shimajiri, PE Ferrand, B Bodey, J Nikkola, UB Hofmann, B Zhang, F Grieu, S Matsumura, E Chicoine, EM Schnaeker, Y Awakura   +53 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Matrix metalloproteinase-9 activity and a downregulated Hedgehog pathway impair blood-brain barrier function in an in vitro model of CNS tuberculosis [PDF]

, 2017
Central nervous system tuberculosis (CNS TB) has a high mortality and morbidity associated with severe inflammation. The blood-brain barrier (BBB) protects the brain from inflammation but the mechanisms causing BBB damage in CNS TB are uncharacterized ...
Brilha, Sara, Couraud, Pierre-Olivier, Friedland, Jon S, Ong, Catherine W M, Romero, Nacho, Weksler, Babette   +5 more
core   +3 more sources

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source