Results 71 to 80 of about 386,755 (358)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Matrix Metalloproteinase 9 Exerts Antiviral Activity against Respiratory Syncytial Virus. [PDF]

PLoS ONE, 2015
Increased lung levels of matrix metalloproteinase 9 (MMP9) are frequently observed during respiratory syncytial virus (RSV) infection and elevated MMP9 concentrations are associated with severe disease.
Abdoulaye J Dabo, Neville Cummins, Edward Eden, Patrick Geraghty   +3 more
doaj   +1 more source

The Significance of Matrix Metalloproteinase 9 (MMP-9) and Metalloproteinase 2 (MMP-2) in Urinary Bladder Cancer

Biomedicines, 2023
Introduction: Urinary bladder cancer is a serious oncological problem that is the cause of many deaths worldwide. The processes of metastasis and origination of local tumor invasion depend on the extracellular matrix (ECM) degradation.
Jacek Kudelski, Anna Tokarzewicz, Monika Gudowska-Sawczuk, Barbara Mroczko, Piotr Chłosta, Marta Bruczko-Goralewska, Przemysław Mitura, Grzegorz Młynarczyk   +7 more
doaj   +1 more source

Ablation of Matrix Metalloproteinase-9 Prevents Cardiomyocytes Contractile Dysfunction in Diabetics [PDF]

, 2016
Elevated expression and activity of matrix metalloproteinase-9 (MMP9) and decreased contractility of cardiomyocytes are documented in diabetic hearts. However, it is unclear whether MMP is involved in the regulation of contractility of cardiomyocytes in ...
Naira eMetreveli, Paras Kumar eMishra, Paras Kumar eMishra, Priyanka ePrathipati, Shyam Sundar Nandi, Suresh Chand Tyagi   +5 more
core   +3 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Identification of matrix metalloproteinase-2 and -9 activities within the intestinal mucosa of dogs with chronic enteropathies

Acta Veterinaria Scandinavica, 2018
Background Matrix metalloproteinases (MMPs) 2 and 9 are zinc- and calcium-dependent endopeptidases involved in the breakdown and reconstitution of extracellular matrix under both physiological and pathological conditions.
Mohsen Hanifeh, Minna Marjaana Rajamäki, Pernilla Syrjä, Laura Mäkitalo, Susanne Kilpinen, Thomas Spillmann   +5 more
doaj   +1 more source

Complex regulation of neutrophil-derived MMP-9 secretion in central nervous system tuberculosis. [PDF]

, 2017
BACKGROUND: Central nervous system tuberculosis (CNS-TB) may be fatal even with treatment. Neutrophils are the key mediators of TB immunopathology, and raised CSF matrix metalloproteinase-9 (MMP-9) which correlates to neutrophil count in CNS-TB is ...
Brilha, S, Elkington, PT, Friedland, JS, Ong, CWM, Pabisiak, PJ, Roncaroli, F, Singh, P   +6 more
core   +1 more source

Matrix metalloproteinase 9 in mucosally invasive gastric cancer [PDF]

Gastric Cancer, 1998
BACKGROUND: Matrix metalloproteinase 9 (MMP-9) facilitates tumor invasion and metastasis via basement membrane degradation. Control of MMP-9 production by cancer-stromal cell interactions in these processes has been observed.METHODS: We measured plasma MMP-9 concentrations, using a one-step sandwich enzyme immunoassay, and also immunohistochemically ...
Akihito, Torii, Yasuhiro, Kodera, Masafumi, Ito, Yasuhiro, Shimizu, Takashi, Hirai, Kenzo, Yasui, Takeshi, Morimoto, Yoshitaka, Yamamura, Tomoyuki, Kato, Taro, Hayakawa, Noboru, Fujimoto, Tsuyoshi, Kito   +11 more
openaire   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Gelatinases Increase in Bleomycin-induced Systemic Sclerosis Mouse Model

Iranian Journal of Allergy, Asthma and Immunology, 2019
Systemic sclerosis is a fibrotic autoimmune disease in which aberrant remodeling of the extracellular matrix in organs disturbs their functionalities.
Fateme Vafashoar, Kazem Mousavizadeh, Hadi Poormoghim, Abbas Tavasoli, Tahereh Musavi Shabestari, Sayed Ali Javadmoosavi, Nazanin Mojtabavi   +6 more
doaj   +1 more source