Results 81 to 90 of about 31,015,536 (305)

Cerebrospinal Fluid Over Plasma Links Analytes to Cognitive Decline in Older Adults at Risk for Alzheimer's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To identify inflammatory analytes in cerebrospinal fluid (CSF) and plasma associated with cognitive decline in cognitively normal (CN) older adults at risk for Alzheimer's disease (AD). Methods In a longitudinal study of 118 CN older adults (65–80 years, 54% APOE ε4, 26% preclinical AD), 1331 CSF and 1501 plasma analytes were ...
Jagan A. Pillai, Audrey Zhu, Chunxuan Ma, Ming Wang, Yifan Yang, Lynn M. Bekris, Maria Khrestian, Frank P. DiFilippo, Mikhail Nasrallah, Aaron Burberry, James B. Leverenz, Yuan Hou, Feixiong Cheng, Stephen M. Rao   +13 more
wiley   +1 more source

The effect of Satureja sahendica Bornm essential oil on the expression of metalloproteases1, 2, 9 and 13 in bovine fibroblast - like syniviocytes [PDF]

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām, 2023
Introduction: Osteoarthritis is a progressive, age-related disease characterized by cartilage destruction, subchondral bone formation, and inflammation of the synovial membrane.
Hossein Maghsoudi, Enayatollah Yazdanpanah, Ali Moheb   +2 more
doaj  

Engineered Microvascular Model of the Blood–Brain–Tumor Barrier Reveals Endothelial Remodeling in Diffuse Midline Glioma

Advanced Healthcare Materials, EarlyView.
We developed a patient‐derived, functional microfluidic model of the diffuse midline glioma (DMG) blood–brain–tumor barrier (BBTB) comprised of endothelial cells, astrocytes, pericytes, and tumor cells. The system forms perfusable microvasculature, reveals the BBTB retains vascular integrity, identifies DMG‐specific transcriptomic changes distinct from
Kimberly R. Bennett, Yann S. Vanrobaeys, Tessy Teboh, Zakiya Smith, Anderson Scott, Cynthia Hajal, Paula T. Hammond, Joelle P. Straehla   +7 more
wiley   +1 more source

PECULIARITIES OF THE FIBROSIS AND CIRRHOSIS MONITORING AMONG CHILDREN WITH CHRONIC LIVER DISEASES

Педиатрическая фармакология, 2009
The researchers examined the opportunities to use determination in the serum among children with chronic liver diseases of various etiologies of the hyaluronic acid levels, collagen type IV, matrix metalloproteinase-2, tissue inhibitor of the matrix ...
A.N. Surkov, I.E. Smirnov, A.S. Potapov, A.G. Kucherenko, E.L. Tumanova   +4 more
doaj   +2 more sources

Factors Involved in Extracellular Matrix Turnover in Human Derived Cardiomyocytes

Cellular Physiology and Biochemistry, 2013
Background: The molecular mechanisms by which myocardial ischemia translates into ventricular remodeling remain unclear. Methods: We investigated whether hypoxia and proinflammatory cytokines are specific inducers of remodeling signals in an in vitro ...
Gregori Casals, Guillermo Fernández-Varo, Pedro Melgar-Lesmes, Santi Marfà, Vedrana Reichenbach, Manuel Morales-Ruiz, Wladimiro Jiménez   +6 more
doaj   +1 more source

Matrix metalloproteinase-13 and membrane type-1 matrix metalloproteinase in peritoneal fluid of women with endometriosis

Gynecological Endocrinology, 2005
It is becoming more and more evident that different types of matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) are involved in the pathogenesis of endometriosis. The aim of the present study was to measure levels of the active forms of MMP-13 and membrane type-1 matrix metalloproteinase (MT1-MMP)/MMP-14 as well as TIMP-2 in the ...
Laudański, Piotr, Jacek Szamatowicz, Ramel, Przymysław   +2 more
openaire   +2 more sources

Dynamic Loading Regulates Meniscus‐Like Matrix Production in Human Mesenchymal Stromal Cell‐Seeded PET Scaffolds

Advanced Healthcare Materials, EarlyView.
Dynamic compression enhances mesenchymal stromal cell proliferation in nonwoven PET scaffolds under chondrogenic differentiation conditions and triggers mechanosensitive transcriptional programs associated with extracellular matrix remodeling. These findings highlight the potential of mechanically stimulated PET scaffolds as a promising platform for ...
Graciosa Quelhas Teixeira, Luisa de Roy, Anna‐Lotta Feldmeier, Mubashir Ahmad, Sofia Pilão, Maria Ahrens, Anita Ignatius, Carsten Linti, Andreas Martin Seitz   +8 more
wiley   +1 more source

Predictive Markers for Hepatocellular Carcinoma Development in Patients with Chronic Hepatitis C Virus Genotype4a

Middle East Journal of Cancer, 2018
Background: Egypt has the highest prevalence of hepatitis C virus worldwide. Monitoring hepatitis C-infected patients for hepatocellular carcinoma development is an important clinical issue to diagnose these patients during the potentially curable ...
Ebtsam R. Zaher, Abeer A. Ghazal, Wael A. Ellabban, Mona El-Deeb, Lamyaa Al-Ghaleed   +4 more
doaj  

Immunohistochemical expression of matrix metalloproteinase-9 and inhibitor of matrix metalloproteinase-1 in prostate adenocarcinoma.

International journal of clinical and experimental pathology, 2015
An immunohistochemical study on the cells proliferative activity by Ki-67 protein and localization of the matrix metalloproteinase-9 and the inhibitor of matrix metalloproteinase-1 was carried out at the benign prostatic hyperplasia (BPH) and the adenocarcinoma (AC) of different Gleason's grades.
Babichenko I.I., Andriukhin M.I., Pulbere S., Loktev A.   +3 more
openaire   +2 more sources

Induced sputum MMP-1, -3 & -8 concentrations during treatment of tuberculosis. [PDF]

, 2013
INTRODUCTION: Tuberculosis (TB) destroys lung tissues and this immunopathology is mediated in part by Matrix Metalloproteinases (MMPs). There are no data on the relationship between local tissue MMPs concentrations, anti-tuberculosis therapy and sputum ...
Jorge Coronel, Friedland, Jon S, Bernabe-Ortiz, A., Coronel, Jorge, Gotuzzo, E., Gotuzzo Eduardo, Antonio Bernabe-Ortiz, Moore, David AJ, Ugarte-Gil, C.A., Coronel Jorge, Elkington, P.T., Moore, D.A.J., Eduardo Gotuzzo, Coronel, J., Paul Elkington, Robert H Gilman, Moore David A. J., Friedland, J.S., Gilman, R., Elkington Paul, Ugarte-Gil, Cesar A, Bernabe-Ortiz Antonio, Gilman Robert H., Cesar A Ugarte-Gil, Friedland Jon S., Elkington, Paul, Jon S Friedland, Gotuzzo, Eduardo, David A J Moore, Ugarte-Gil Cesar A., Tezera, Liku B, Gilman, Robert H, Liku B Tezera, Tezera Liku B., Bernabe-Ortiz, Antonio   +34 more
core   +1 more source