Matrix Metalloproteinase 13 Is Associated with Age-Related Choroidal Neovascularization [PDF]
Antioxidants, 2023 Age-related macular degeneration (AMD) is a leading cause of severe vision loss in older individuals in developed countries. Despite advances in our understanding of AMD, its pathophysiology remains poorly understood.
Jorge González-Zamora +8 more
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Interleukin 36 receptor-inducible matrix metalloproteinase 13 mediates intestinal fibrosis [PDF]
Frontiers in Immunology, 2023 BackgroundFibrostenotic disease is a common complication in Crohn’s disease (CD) patients hallmarked by transmural extracellular matrix (ECM) accumulation in the intestinal wall.
Kristina Koop +19 more
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Potential Value of Matrix Metalloproteinase-13 as a Biomarker for Osteoarthritis [PDF]
Frontiers in Surgery, 2021 Background: Emerging knowledge has highlighted the role of matrix metalloproteinase (MMP)-13 in osteoarthritis (OA); however, the suitability of MMP-13 as a biomarker for OA remains unclear.
Xing Xin +16 more
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(2-Aminobenzothiazole)-Methyl-1,1-Bisphosphonic Acids: Targeting Matrix Metalloproteinase 13 Inhibition to the Bone [PDF]
Pharmaceuticals, 2021 Matrix Metalloproteinases (MMPs) are a family of secreted and membrane-bound enzymes, of which 24 isoforms are known in humans. These enzymes degrade the proteins of the extracellular matrix and play a role of utmost importance in the physiological ...
Antonio Laghezza +6 more
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Serum matrix metalloproteinase-13 as a diagnostic biomarker for cutaneous squamous cell carcinoma [PDF]
BMC Cancer, 2021 Background A significant proportion of newly diagnosed patients with cutaneous squamous cell carcinoma (cSCC) have metastasis and eventually die of the disease, necessitating the exploration of novel biomarkers for early detection of cSCC aggressiveness,
Hui Wang +6 more
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Matrix Metalloproteinase‐13 Is an Unfavorable Prognostic Factor in Chordoma by Digesting Growth Inhibitory Collagens [PDF]
Cancer MedicineObjective Chordomas are low‐grade but invasive tumors with limited therapies. Some conventional chordomas exhibit cartilage‐like extracellular matrix (ECM).
Yumiko Oishi +6 more
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Matrix Metalloproteinase 13 Activity is Required for Normal and Hypoxia-Induced Precocious Hatching in Zebrafish Embryos [PDF]
Journal of Developmental Biology, 2020 Hypoxia induces precocious hatching in zebrafish, but we do not have a clear understanding of the molecular mechanisms regulating the activation of the hatching enzyme or how these mechanisms trigger precocious hatching under unfavorable environmental ...
Christopher D. Small +4 more
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A ROS-responsive hydrogel encapsulated with matrix metalloproteinase-13 siRNA nanocarriers to attenuate osteoarthritis progression [PDF]
Journal of NanobiotechnologyRNA interference (RNAi) and oxidative stress inhibition therapeutic strategies have been extensively utilized in the treatment of osteoarthritis (OA), the most prevalent degenerative joint disease.
Qiuyang Wang +8 more
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Differential expression of matrix metalloproteinase-13 in association with invasion of breast cancer [PDF]
Contemporary Oncology, 2016 Matrix metalloproteinase-13 (MMP-13) has a potential role in tumour invasion and metastasis. However, its relevance to the prognosis of human breast cancer is poorly understood.
Manas Kotepui +5 more
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Proprotein convertase furin inhibits matrix metalloproteinase 13 in a TGFβ-dependent manner and limits osteoarthritis in mice [PDF]
Scientific Reports, 2018 Cartilage loss in osteoarthritis (OA) results from altered local production of growth factors and metalloproteases (MMPs). Furin, an enzyme involved in the protein maturation of MMPs, might regulate chondrocyte function.
Hilène Lin +8 more
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