Results 41 to 50 of about 75,485,891 (288)

Matrix metalloproteinase 13 is induced in fibroblasts in polyomavirus middle T antigen-driven mammary carcinoma without influencing tumor progression [PDF]

, 2008
Matrix metalloproteinase (MMP) 13 (collagenase 3) is an extracellular matrix remodeling enzyme that is induced in myofibroblasts during the earliest invasive stages of human breast carcinoma, suggesting that it is involved in tumor progression.
Lund, Leif R, Zena Werb, Dylan R Edwards, Askautrud, Hanne A, Lund, Leif R., Mikala Egeblad, Pedersen, T. X., Edwards, D. R., Leif R Lund, Rank, Fritz, Ib J Christensen, Pedersen, Tanja X., Fritz Rank, Nielsen, Boye S., Christensen, Ib J, Askautrud, Hanne A., Lund, L. R., Edwards, Dylan R., Tanja X Pedersen, Boye S Nielsen, Werb, Zena, Egeblad, M., Christensen, I. J., Caroline J Pennington, Hanne A Askautrud, Rank, F., Edwards, Dylan R, Werb, Z., Askautrud, H. A., Nielsen, Boye S, Pennington, C. J., Egeblad, Mikala, Christensen, Ib J., Pennington, Caroline J, Pennington, Caroline J., Nielsen, B. S., Pedersen, Tanja X   +36 more
core   +1 more source

Quercetin prevent proteoglycan destruction by inhibits matrix metalloproteinase-9, matrix metalloproteinase-13, a disintegrin and metalloproteinase with thrombospondin motifs-5 expressions on osteoarthritis model rats

Journal of Advanced Pharmaceutical Technology & Research, 2019
Prior study has shown that Ageratum conyzoides L. extract that containing quercetin has been proved to prevent inflammation and proteoglycan degradation by inhibiting tumor necrosis factor-alpha and matrix metalloproteinase (MMP-9) expression.
Dian Agustina Permatasari, Deantari Karliana, Iskandarsyah Iskandarsyah, Ade Arsianti, Anton Bahtiar   +4 more
doaj   +1 more source

Human keratinocyte cell lines differ in the expression of the collagenolytic matrix metalloproteinases-1,-8, and-13 and of TIMP-1 [PDF]

, 2000
Bachmeier BE, Nerlich AG, Boukamp P, et al. Human keratinocyte cell lines differ in the expression of the collagenolytic matrix metalloproteinases-1,-8, and-13 and of TIMP-1. BIOLOGICAL CHEMISTRY.
Bachmeier, B. E., Nerlich, A. G., Fink, E., Fritz, H., Tschesche, H., Lichtinghagen, R., Boukamp, P., Boukamp, P, Tschesche, Harald, Bachmeier, BE, Fritz, H, Fink, E, Nerlich, AG, Lichtinghagen, R   +13 more
core   +1 more source

Cell surface engineering of renal cell carcinoma with glycosylphosphatidylinositol-anchored TIMP-1 blocks TGF-beta 1 activation and reduces regulatory ID gene expression [PDF]

, 2012
Tissue inhibitor of metalloproteinase 1 (TIMP-1) controls matrix metalloproteinase activity through 1:1 stoichiometric binding. Human TIMP-1 fused to a glycosylphosphatidylinositol (GPI) anchor (TIMP-1-GPI) shifts the activity of TIMP-1 from the ...
Notohamiprodjo, Susan, Jaeckel, Carsten, Djafarzadeh, Roghieh, Hofstetter, Monika, Nelson, Peter J., Rieth, Nicole   +5 more
core   +1 more source

TIPE2 Mediates the Suppressive Effects of Shikonin on MMP13 in Osteosarcoma Cells

Cellular Physiology and Biochemistry, 2015
Background/Aims: Osteosarcoma (OS) is a primary malignant bone tumor in humans, and is notorious mainly for its distal metastases. We have recently shown that Shikonin, an effective constituent extracted from Chinese medicinal herb, inhibits OS cell ...
Biyong Deng, Youwei Feng, Bixiang Deng
doaj   +1 more source

Tumor-derived matrix metalloproteinase-13 (MMP-13) correlates with poor prognosis of invasive breast cancer

BMC Cancer, 2008
Background Experimental evidence suggests that matrix metalloproteinase-13 (MMP-13) protein may promote breast tumor progression, however, its role is yet to be fully established.
Ning Liansheng, Li Hongtao, Zhang Shiwu, Zhang Fei, Cao Wenfeng, Liu Yanxue, Cao Xuchen, Zhang Bin, Fu Li, Niu Yun, Niu Ruifang, Sun Baocun, Hao Xishan   +12 more
doaj   +1 more source

Natural Compounds: Potential Therapeutics for the Inhibition of Cartilage Matrix Degradation in Osteoarthritis

Life, 2022
Osteoarthritis (OA) is the most common degenerative joint disease characterized by enzymatic degradation of the cartilage extracellular matrix (ECM) causing joint pain and disability.
Omer S. Ashruf, Mohammad Yunus Ansari
doaj   +1 more source

Matrix Metalloproteinase 12-Deficiency Augments Extracellular Matrix Degrading Metalloproteinases and Attenuates IL-13–Dependent Fibrosis [PDF]

The Journal of Immunology, 2010
Abstract Infection with the parasitic helminth Schistosoma mansoni causes significant liver fibrosis and extracellular matrix (ECM) remodeling. Matrix metalloproteinases (MMP) are important regulators of the ECM by regulating cellular inflammation, extracellular matrix deposition, and tissue reorganization.
Satish K, Madala, John T, Pesce, Thirumalai R, Ramalingam, Mark S, Wilson, Samantha, Minnicozzi, Allen W, Cheever, Robert W, Thompson, Margaret M, Mentink-Kane, Thomas A, Wynn   +8 more
openaire   +2 more sources

Development of a Non-Hydroxamate Dual Matrix Metalloproteinase (MMP)-7/-13 Inhibitor

Molecules, 2017
Matrix metalloproteinase 7 (MMP-7) is a member of the MMP superfamily and is able to degrade extracellular matrix proteins such as casein, gelatin, fibronectin and proteoglycan.
Thomas Fischer, Rainer Riedl
doaj   +1 more source

Repair Effects of Xiaoyusan New Formula on Cartilage Injury and MMP-13 Expression in Knee Osteoarthritis Model Rabbits

Shiyan dongwu yu bijiao yixue, 2023
ObjectiveTo study the effect of Xiaoyusan new formula on the articular cartilage of knee osteoarthritis (KOA) rabbits and its mechanism.MethodsA total of 42 New Zealand white rabbits aged 6 months were randomly divided into normal group, model group ...
CUI Ruolin, WANG Qing, YANG Ling, FENG Wenchang, LIU Zhiwei, TENG Weiran, MA Bitao, WANG Leyang, QIN Liping, JIN Lilun   +9 more
doaj   +1 more source