Modulation of autocrine TNF-α-stimulated matrix metalloproteinase 9 (MMP-9) expression by mitogenactivated protein kinases in THP-1 monocytic cells [PDF]
, 2006 Matrix metalloproteinase 9 (MMP-9) is implicated in various physiological processes by its ability to degrade the extracellular matrix (ECM) and process multiple regulatory proteins. Normally, MMP-9 expression is tightly controlled in cells. Sustained or
Helmut Kolb +9 more
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Pharmaceuticals, 2021 Arthritis is a common inflammatory disease that causes pain, stiffness, and joint swelling. Here, we investigated the ameliorative effects of loganin on arthritis in vitro and in vivo. A single bioactive compound was fractionated and isolated from Cornus
Eunkuk Park +9 more
doaj +1 more source
Matrix Metalloproteinase-13 Predominates Over Matrix Metalloproteinase-8 as the Functional Interstitial Collagenase in Mouse Atheromata [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2014 Objective— Substantial evidence implicates interstitial collagenases of the matrix metalloproteinase (MMP) family in plaque rupture and fatal thrombosis. Understanding the compensatory mechanisms that may influence the expression of these enzymes and their functions, therefore, has important clinical implications.
Quillard, T. +4 more
openaire +4 more sources
Contribution of Matrix Metalloproteinase-9 to Cerebral Edema and Functional Outcome following Experimental Subarachnoid Hemorrhage [PDF]
, 2011 Background: Cerebral edema is an important risk factor for death and poor outcome following subarachnoid hemorrhage (SAH). However, underlying mechanisms are still poorly understood.
Karsten Schöller +9 more
core +1 more source
Matrix metalloproteinase 13, a new target for therapy in Alzheimer's disease. [PDF]
Genes Dis, 2019 Alzheimer's disease (AD), the most common neurodegenerative disorder, affects millions of people worldwide. In a recent publication, Guo-Jun Chen and colleagues highlight the role of matrix metalloproteinase (MMP) 13 (also called Collagenase 3) in AD pathogenesis through regulating BACE1, 1 a rate-limiting enzyme for β-amyloid (Aβ ...
Paumier JM, Thinakaran G.
europepmc +3 more sources
Prospective study of matrix metalloproteinase-9 and risk of myocardial infarction and stroke in older men and women [PDF]
, 2009 OBJECTIVES: The endopeptidase matrix metalloproteinase-9 (MMP-9) is implicated in atherosclerotic plaque rupture. We investigate prospective associations between MMP-9 and MI or stroke in an older general population cohort, accounting for established and
Lowe, Gordon +33 more
core +1 more source
BMC Research Notes, 2010 Background Mechanical strain plays a significant role in the regulation of bone matrix turnover, which is mediated in part by matrix metalloproteinase (MMP)-13 and tissue inhibitors of matrix metalloproteinase (TIMP)-1. However, little is known about the
Duan Yinzhong +3 more
doaj +1 more source
Role of matrix metalloproteinase 13 in both endochondral and intramembranous ossification during skeletal regeneration. [PDF]
PLoS ONE, 2007 Extracellular matrix (ECM) remodeling is important during bone development and repair. Because matrix metalloproteinase 13 (MMP13, collagenase-3) plays a role in long bone development, we have examined its role during adult skeletal repair. In this study
Danielle J Behonick +8 more
doaj +1 more source
Biological Markers in Fundamental and Clinical Medicine (collection of abstracts), 2018 MATRIX METALLOPROTEINASE -14 AND MATRIX METALLOPROTEINASE -13 ARE THE POTENTIAL MARKERS OF THE CHRONIC ...
E.L. Kolb, L.A. Kazeko
openaire +2 more sources
Chemokine-induced secretion of gelatinase B in primary human monocytes [PDF]
, 2001 Chemokines help control normal leukocyte trafficking as well as their infiltration into tissues during acute and chronic inflammation. Matrix metalloproteinases (MMPs) help support the extravasation and infiltration of leukocytes through limited ...
Nelson, EL +17 more
core +1 more source