Results 21 to 30 of about 75,485,891 (288)

Role of Gene Polymorphisms of Matrix Metalloproteinases-2, -3 and -13 in the Development of Coronary Artery Atherosclerosis in Patients with Primary Polyosteoarthrosis

Архивъ внутренней медицины, 2020
The aim of the research. To assess the influence of polymorphisms of the matrix metalloproteinase genes — 2 (rs2285053), — 3 (rs3025058), and — 13 (rs2252070) on the development of coronary atherosclerosis in patients with primary osteoarthritis ...
O. O. Portyannikova, E. N. Romanova, A. V. Govorin, S. M. Tsvinger   +3 more
doaj   +1 more source

Development of a selective matrix metalloproteinase 13 (MMP-13) inhibitor for the treatment of Osteoarthritis. [PDF]

Eur J Med Chem, 2021
Osteoarthritis (OA) is a chronic disorder that causes damage to the cartilage and surrounding tissues and is characterized by pain, stiffness, and loss of function. Current treatments for OA primarily involve providing only relief of symptoms but does not affect the overall trajectory of the disease.
Bendele AM, Neelagiri M, Neelagiri V, Sucholeiki I.   +3 more
europepmc   +3 more sources

The expression of matrix metalloproteinase-13 (MMP-13) on xenograft and PRF in bone regeneration

Brazilian Dental Science, 2023
Objective: inflammation may play a role in bone loss by altering the bone remodelling process, favouring bone resorption by osteoclasts over bone synthesis by osteoblasts.
Eka Fitria Augustina, Nur Riflianty Rivai, Haykal Miftah Gifary   +2 more
doaj   +1 more source

The association between MMP−13 rs478927 gene polymorphism and dental caries susceptibility in children with mixed dentition from Birjand, Iran: A case‐control study

Health Science Reports, 2023
Background and Aims Gene polymorphisms are responsible for at least part of the variation in caries susceptibility despite similar environmental factors.
Ebrahim Miri‐Moghaddam, Fatemeh Sadat Mousavi, Hamid Salehiniya, Farzaneh Vafaeie, Hamid Abbaszadeh   +4 more
doaj   +1 more source

Evaluation of the Effect of Phytocomplex on Chondroprotective Biomarkers in an Experimental Model of Osteoarthritis in Rats [PDF]

Modern Medicine, 2022
Osteoarthritis (OA) is most prevalent joint disease and major contributor to non-fatal burden in India, with prevalence rates of 22% - 39%. The use of conventional medication can be associated with insufficient clinical management and serious side ...
Shridhar PANDYA, Chetan SAVALIYA, Dheeraj NAGORE, Vaishali UNDALE, Shubhada KHADE, Nishant MANTE   +5 more
doaj   +1 more source

Characterization of an exosite binding inhibitor of matrix metalloproteinase 13 [PDF]

Protein Science, 2008
AbstractMatrix metalloproteinase 13 (MMP13) is a key enzyme implicated in the degradation of the extracellular matrix in osteoarthritis. Clinical administration of broad spectrum MMP inhibitors such as marimastat has been implicated in severe musculo‐skeletal side effects. Consequently, research has been focused on designing inhibitors that selectively
Lata T, Gooljarsingh, Ami, Lakdawala, Frank, Coppo, Lusong, Luo, Gregg B, Fields, Peter J, Tummino, Richard R, Gontarek   +6 more
openaire   +2 more sources

Matrix metalloproteinases at key junctions in the pathomechanism of stroke [PDF]

, 2011
Matrix metalloproteinases play a crucial role in the remodelling of the extracellular matrix through direct degradation of its structural proteins and control of extracellular signaling.
Kolev, Kraszimir, Kolev Krasimir, Rottenberger Zsolt, Zsolt Rottenberger, Rottenberger, Zsolt, Krasimir Kolev   +5 more
core   +1 more source

Targeting matrix metalloproteinase‐13 in bronchial epithelial repair [PDF]

Clinical & Experimental Allergy, 2018
AbstractBackgroundViral infection of the bronchial epithelium disrupts the barrier properties of the epithelium in healthy individuals and those with lung disease. Repair of the bronchial epithelium is dependent of the formation of a provisional fibrin matrix and migration of epithelial cells to cover denuded areas, followed by proliferation and ...
Christopher Howell, James R. Smith, Janis K. Shute   +2 more
openaire   +2 more sources

Leptin and Pro-Inflammatory Stimuli Synergistically Upregulate MMP-1 and MMP-3 Secretion in Human Gingival Fibroblasts [PDF]

, 2016
Introduction Gingival fibroblast-mediated extracellular matrix remodelling is implicated in the pathogenesis of periodontitis, yet the stimuli that regulate this response are not fully understood. The immunoregulatory adipokine leptin is detectable in
Andrew J Skelton, Todryk, Stephen M., Rowan, Andrew, Skelton, Andrew J., Skelton, Andrew J, Williams, Rachel C., Preshaw, Philip M.; id_orcid, Preshaw, Philip M, Taylor, John, Rowan, Andrew D., Skelton, Andrew, Preshaw, Philip, Taylor, John J, Taylor, John J., Todryk, Stephen, Philip M Preshaw, Todryk, Stephen M, Rachel C Williams, Stephen M Todryk, Williams, Rachel C, Andrew D Rowan, Rowan, Andrew D, John J Taylor, Williams Rachel C., Rowan Andrew D., Taylor John J., Skelton Andrew J., Todryk Stephen M., Preshaw Philip M.   +28 more
core   +2 more sources

Matrix metalloproteinase-13 and membrane type-1 matrix metalloproteinase in peritoneal fluid of women with endometriosis

Gynecological Endocrinology, 2005
It is becoming more and more evident that different types of matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) are involved in the pathogenesis of endometriosis. The aim of the present study was to measure levels of the active forms of MMP-13 and membrane type-1 matrix metalloproteinase (MT1-MMP)/MMP-14 as well as TIMP-2 in the ...
Laudański, Piotr, Jacek Szamatowicz, Ramel, Przymysław   +2 more
openaire   +3 more sources