Results 21 to 30 of about 126,856 (109)

Immunohistochemical analysis of matrix metalloproteinase-13 in human caries dentin

European Journal of Histochemistry, 2014
The immunoexpression profile of matrix metalloproteinase-13 was investigated for the first time in dentin of human caries and healthy teeth. Twelve permanent premolars (10 caries and 2 sound) were decalcified in ethylenediaminetetraacetic acid and ...
C. Loreto, C. Galanti, G. Musumeci, M. C. Rusu, R. Leonardi   +4 more
doaj   +1 more source

Role of matrix metalloproteinase 13 in both endochondral and intramembranous ossification during skeletal regeneration. [PDF]

PLoS ONE, 2007
Extracellular matrix (ECM) remodeling is important during bone development and repair. Because matrix metalloproteinase 13 (MMP13, collagenase-3) plays a role in long bone development, we have examined its role during adult skeletal repair. In this study
Danielle J Behonick, Zhiqing Xing, Shirley Lieu, Jenni M Buckley, Jeffrey C Lotz, Ralph S Marcucio, Zena Werb, Theodore Miclau, Céline Colnot   +8 more
doaj   +1 more source

Upregulation of MMP-13 and TIMP-1 expression in response to mechanical strain in MC3T3-E1 osteoblastic cells

BMC Research Notes, 2010
Background Mechanical strain plays a significant role in the regulation of bone matrix turnover, which is mediated in part by matrix metalloproteinase (MMP)-13 and tissue inhibitors of matrix metalloproteinase (TIMP)-1. However, little is known about the
Duan Yinzhong, Tang Lin, Li Yongming, Ding Yin   +3 more
doaj   +1 more source

Quercetin prevent proteoglycan destruction by inhibits matrix metalloproteinase-9, matrix metalloproteinase-13, a disintegrin and metalloproteinase with thrombospondin motifs-5 expressions on osteoarthritis model rats

Journal of Advanced Pharmaceutical Technology & Research, 2019
Prior study has shown that Ageratum conyzoides L. extract that containing quercetin has been proved to prevent inflammation and proteoglycan degradation by inhibiting tumor necrosis factor-alpha and matrix metalloproteinase (MMP-9) expression.
Dian Agustina Permatasari, Deantari Karliana, Iskandarsyah Iskandarsyah, Ade Arsianti, Anton Bahtiar   +4 more
doaj   +1 more source

TIPE2 Mediates the Suppressive Effects of Shikonin on MMP13 in Osteosarcoma Cells

Cellular Physiology and Biochemistry, 2015
Background/Aims: Osteosarcoma (OS) is a primary malignant bone tumor in humans, and is notorious mainly for its distal metastases. We have recently shown that Shikonin, an effective constituent extracted from Chinese medicinal herb, inhibits OS cell ...
Biyong Deng, Youwei Feng, Bixiang Deng
doaj   +1 more source

Tumor-derived matrix metalloproteinase-13 (MMP-13) correlates with poor prognosis of invasive breast cancer

BMC Cancer, 2008
Background Experimental evidence suggests that matrix metalloproteinase-13 (MMP-13) protein may promote breast tumor progression, however, its role is yet to be fully established.
Ning Liansheng, Li Hongtao, Zhang Shiwu, Zhang Fei, Cao Wenfeng, Liu Yanxue, Cao Xuchen, Zhang Bin, Fu Li, Niu Yun, Niu Ruifang, Sun Baocun, Hao Xishan   +12 more
doaj   +1 more source

Natural Compounds: Potential Therapeutics for the Inhibition of Cartilage Matrix Degradation in Osteoarthritis

Life, 2022
Osteoarthritis (OA) is the most common degenerative joint disease characterized by enzymatic degradation of the cartilage extracellular matrix (ECM) causing joint pain and disability.
Omer S. Ashruf, Mohammad Yunus Ansari
doaj   +1 more source

Development of a Non-Hydroxamate Dual Matrix Metalloproteinase (MMP)-7/-13 Inhibitor

Molecules, 2017
Matrix metalloproteinase 7 (MMP-7) is a member of the MMP superfamily and is able to degrade extracellular matrix proteins such as casein, gelatin, fibronectin and proteoglycan.
Thomas Fischer, Rainer Riedl
doaj   +1 more source

Repair Effects of Xiaoyusan New Formula on Cartilage Injury and MMP-13 Expression in Knee Osteoarthritis Model Rabbits

Shiyan dongwu yu bijiao yixue, 2023
ObjectiveTo study the effect of Xiaoyusan new formula on the articular cartilage of knee osteoarthritis (KOA) rabbits and its mechanism.MethodsA total of 42 New Zealand white rabbits aged 6 months were randomly divided into normal group, model group ...
CUI Ruolin, WANG Qing, YANG Ling, FENG Wenchang, LIU Zhiwei, TENG Weiran, MA Bitao, WANG Leyang, QIN Liping, JIN Lilun   +9 more
doaj   +1 more source

The effect of Satureja sahendica Bornm essential oil on the expression of metalloproteases1, 2, 9 and 13 in bovine fibroblast - like syniviocytes [PDF]

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām, 2023
Introduction: Osteoarthritis is a progressive, age-related disease characterized by cartilage destruction, subchondral bone formation, and inflammation of the synovial membrane.
Hossein Maghsoudi, Enayatollah Yazdanpanah, Ali Moheb   +2 more
doaj