Results 41 to 50 of about 2,132,854 (249)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

A note on indefinite matrix splitting and preconditioning [PDF]

The solution of systems of linear(ized) equations lies at the heart of many problems in Scientific Computing. In particular for systems of large dimension, iterative methods are a primary approach.

core   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

A Robust Hermitian and Skew-Hermitian Based Multiplicative Splitting Iterative Method for the Continuous Sylvester Equation

Mathematics
For solving the continuous Sylvester equation, a class of Hermitian and skew-Hermitian based multiplicative splitting iteration methods is presented. We consider two symmetric positive definite splittings for each coefficient matrix of the continuous ...
Mohammad Khorsand Zak, Abbas Abbaszadeh Shahri   +1 more
doaj   +1 more source

Accelerated normal and skew-Hermitian splitting methods for positive definite linear systems [PDF]

Iranian Journal of Numerical Analysis and Optimization, 2013
For solving large sparse non-Hermitian positive definite linear equations, Bai et al. proposed the Hermitian and skew-Hermitian splitting methods (HSS). They recently generalized this technique to the normal and skew-Hermitian splitting methods (NSS). In
F. Toutounian, Davood Hezari
doaj   +1 more source

Multiway Splitting Method for Toeplitz Matrix Vector Product

, 2013
International audienceComputing the product of a Toeplitz matrix and a vector arises in various applications including cryptography. In this paper, we consider Toeplitz matrices and vectors with entries in $({hbox{rlap{I}kern 2.0pt{hbox{F}}}}_2)$.
Hasan, Anwar, Negre, Christophe
core   +1 more source

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

Molecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński, Krzysztof Pastuszak, Anna Samelak‐Czajka, Zuzanna Cemka, Paulina Jackowiak, Tomasz Stefaniak, Sylwia Łapińska‐Szumczyk, Jacek Jassem, Anna J. Żaczek, Matthew T. Rondina, Myron G. Best, Sjors G. J. G. In 't Veld, Anna Supernat   +12 more
wiley   +1 more source

Relaxed Modulus-Based Matrix Splitting Methods for the Linear Complementarity Problem

, 2021
In this paper, we obtain a new equivalent fixed-point form of the linear complementarity problem by introducing a relaxed matrix and establish a class of relaxed modulus-based matrix splitting iteration methods for solving the linear complementarity ...
Praveen Agarwal, Shiliang Wu, Cuixia Li
core   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

An Eigen-based Matrix Inverse Approximation Scheme with Stair Matrix Splitting for Massive MIMO Systems

, 2019
Approximative matrix inversion (MIA) has been extensively researched with the aim of addressing the complexity issues encountered by Zero-forcing (ZF) precoder design in massive multiple-input multiple-output (MIMO) systems.
Phil Chia-Yang Tsai; Kelvin Kuang-Chi Lee; Chiao-En Chen
core   +1 more source