Results 51 to 60 of about 74,666 (264)

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Efficient time-splitting Hermite-Galerkin spectral method for the coupled nonlinear Schrödinger equations

Journal of Algorithms & Computational Technology, 2020
The paper focuses on efficient time-splitting Hermite-Galerkin spectral approximation of the coupled nonlinear Schrödinger equations on the whole line.
Qingqu Zhuang, Yi Yang
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

A Two-Step Matrix-Splitting Iterative Method for Solving the Generalized Absolute Value Equation

Journal of Mathematics
In this paper, we present a two-step Newton-based matrix-splitting iteration method for solving the generalize absolute value equation. This method can produce a number of two-step Newton-based relaxation iteration algorithms with the right matrix ...
Lin Zheng, Yangxin Tang
doaj   +1 more source

On general fixed point method based on matrix splitting for solving linear complementarity problem

Journal of Numerical Analysis and Approximation Theory, 2022
In this article, we introduce a modified fixed point method to process the large and sparse linear complementarity problem (LCP) and formulate an equivalent fixed point equation for the LCP and show the equivalence.
Bharat Kumar, Deepmala, A. K. Das
doaj  

Impact of twisting high-performance polyethylene fibre bundle reinforcements on the mechanical characteristics of high-strength concrete

Materiales de Construccion, 2019
The quasi-static and dynamic mechanical behaviours of the concrete reinforced by twisting ultra-high molecular weight polyethylene (UHMWPE) fibre bundles with different volume fractions have been investigated.
Y. Zhang, L. Yan, S. Wang, M. Xu
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

A Lie algebra view of matrix splittings

Linear Algebra and its Applications
In this paper we use some basic facts from the theory of (matrix) Lie groups and algebras to show that many of the classical matrix splittings used to construct stationary iterative methods and preconditioniers for Krylov subspace methods can be interpreted as linearizations of matrix factorizations.
Benzi, Michele, Viviani, Milo
openaire   +2 more sources