Results 51 to 60 of about 501,769 (296)

A relaxed block splitting preconditioner for complex symmetric indefinite linear systems

open access: yesOpen Mathematics, 2018
In this paper, we propose a relaxed block splitting preconditioner for a class of complex symmetric indefinite linear systems to accelerate the convergence rate of the Krylov subspace iteration method and the relaxed preconditioner is much closer to the ...
Huang Yunying, Chen Guoliang
doaj   +1 more source

A medium-shifted splitting iteration method for a diagonal-plus-Toeplitz linear system from spatial fractional Schrödinger equations

open access: yesBoundary Value Problems, 2018
The centered difference discretization of the spatial fractional coupled nonlinear Schrödinger equations obtains a discretized linear system whose coefficient matrix is the sum of a real diagonal matrix D and a complex symmetric Toeplitz matrix T̃ which ...
Ruiping Wen, Peipei Zhao
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

New accelerated modulus-based iteration method for solving large and sparse linear complementarity problem

open access: yesJournal of Numerical Analysis and Approximation Theory
For the large and sparse linear complementarity problem, we provide a family of new accelerated modulus-based iteration methods in this article. We provide some sufficient  criteria for the convergence analysis when the  system matrix is a \(P\)-matrix ...
Bharat Kumar, Deepmala, A. K. Das
doaj   +1 more source

On the convergence of two-step modulus-based matrix splitting iteration method

open access: yesOpen Mathematics, 2021
In this paper, based on the relationship between the linear complementarity problem and its reformulated fixed-point equation, we discuss the conditions of the modulus-based type iteration methods. Moreover, we present some convergence results on the two-
Fang Ximing, Fu Shouzhong, Gu Ze
doaj   +1 more source

Electron tunneling in the germanium/silicon heterostructure with germanium quantum dots: theory

open access: yesХімія, фізика та технологія поверхні, 2021
It is shown that electron tunneling through a potential barrier that separates two quantum dots of germanium leads to the splitting of electron states localized over spherical interfaces (a quantum dot – a silicon matrix).
S. I. Pokutnyi, N. G. Shkoda
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

解非对称鞍点问题的广义交替分裂预处理子的一个注记(A note of generalized shift-splitting preconditioners for nonsymmetric saddle point problems)

open access: yesZhejiang Daxue xuebao. Lixue ban, 2017
Recently, CAO et al introduced a generalized shift-splitting preconditioner for saddle point problems with nonsymmetric positive definite (1, 1)-block.
ZHANGLitao(张理涛)   +2 more
doaj   +1 more source

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