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The Stability of Theophylline Tablets with a Hydroxypropylcellulose Matrix
Drug Development and Industrial Pharmacy, 2000The behavior of 40:60 anhydrous theophylline/hydroxypropylcellulose (HPC) direct compression tablets obtained using a variety of hydroxypropylcelluloses with low or medium-high degrees of substitution (L-HPCs and HPCs, respectively) was determined immediately following their preparation and after storage for 6 months at 20 degrees C and a relative ...
C, Alvarez-Lorenzo +4 more
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The Influence of Matrix Technology on the Subdivision of Sustained Release Matrix Tablets
AAPS PharmSciTech, 2019The subdivision of sustained release tablets is a controversial issue, especially concerning its impact on dissolution profiles. The purpose of this study was to elucidate the behavior upon subdivision of this class of tablets. For this, three common sustained release matrices containing different technologies were selected, e.g., a tablet comprised of
Teixeira, Maíra Teles +7 more
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Study of drug release and tablet characteristics of silicone adhesive matrix tablets
European Journal of Pharmaceutics and Biopharmaceutics, 2012Matrix tablets of a model drug acetaminophen (APAP) were prepared using a highly compressible low glass transition temperature (T(g)) polymer silicone pressure sensitive adhesive (PSA) at various binary mixtures of silicone PSA/APAP ratios. Matrix tablets of a rigid high T(g) matrix forming polymer ethyl cellulose (EC) were the reference for comparison.
Gaurav, Tolia, S Kevin, Li
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Divisability of Diltiazem Matrix Sustained-Release Tablets
Pharmaceutical Development and Technology, 2001The objective of this work was to study the possibility of a solid sustained-release dosage form, like a tablet, be divided without changing its release characteristics. Diltiazem hydrochloride Sustained-Release (SR) tablets with a standard groove on one face, were tested and the following dissolution parameters were evaluated: t10%, t25%, and t50 ...
P, Costa, J M, Sousa Lobo
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Controlled release of saccharides from matrix tablets
European Journal of Pharmaceutics and Biopharmaceutics, 2006The aim of this study was to design site specific, controlled release tablets of N-acetyl-d-glucosamine (NAG), maltose monohydrate and maltopentaose by using hydrophobic matrix formers starch acetate (SA) and ethyl cellulose (EC). The optimized matrices, which had either low porosity and high drug load or high porosity and low drug load, released the ...
Riikka, Mäki +6 more
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Communication: Matrix Tablets of Salbutamol Sulphate
Drug Development and Industrial Pharmacy, 1990AbstractControlled release tablet of Salbutamol has been shown to be clinically superior to the standard 4 mg Salbutamol tablets given 3–4 times daily. Salbutamol-Sulphate sustained release tablets based on two marketed polymers, Eudragit and Methocel, is presented here. Effect of water insoluble diluents on in vitro drug release was evaluated.
N. M. Sanghavi +3 more
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Matrix Tablets of Carrageenans. I. A Compaction Study*
Drug Development and Industrial Pharmacy, 1999Carrageenans can be used as excipients for controlled-release tablets. The aim of this study was to determine their compaction and consolidation behavior to prove their usefulness for tableting. The Carr indices of the three carrangeenans, two kappa-carrageenans(Gelcarin GP-812 NF and GP-911 NF) and one tau-carrageenan (Gelcarin GP-379 NF), indicate ...
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Formulation and Evaluation of Rizatriptan Matrix Tablet
Research Journal of Pharmacy and Technology, 2016Mucoadhesive polymer owing to its binding capacity with gastric mucin prolongs the gastric residence time and thereby increases bioavailability. In the present research work an attempt was made to formulate and evaluate sustain release mucoadhesive matrix tablet of Rizatriptan.
Jobin Jose +2 more
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Formulation and Evaluation of Aceclofenac Matrix Tablet
International Journal of Scientific Research, 2012The aim of the study was to develop matrix tablets of Aceclofenac by wet granulation using hydrophilic polymer like Hydroxy propyl methyl cellulose K -100. Hydroxy propyl methyl cellulose K -15 Hydroxy propyl methyl cellulose K -4M The drug excipient mixtures were subjected to preformulation studies.
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Tablet formation and release from matrix tablets manufactured with cellulose acetate
International Journal of Pharmaceutics, 1998Cellulose acetate has been successful in the production of matrix tablets but contradictory results exist also. Therefore, in this study it is used to elucidate the dependency of drug release from tablet formation and the factors influencing the microstructure of the tablet, such as densification, different particle size fractions, the dwell time ...
Katharina M. Picker, Fatima Bikane
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