Results 71 to 80 of about 188,223,062 (256)

Hepatocyte CBX2 Safeguards Hepatic Lipid Homeostasis by Elevating Ca2+‐CaMKK2‐AMPK Signaling to Counter MASLD

Advanced Science, EarlyView.
In hepatocytes, CBX2 promotes H3K4me3 enrichment at the Orai1 promoter to enhance Orai1 transcriptional activation, thereby increasing intracellular Ca2+ levels. The elevated Ca2+ activates the CaMKK2‐AMPK signaling cascade, resulting in ACC phosphorylation and downstream metabolic regulation. This cascade suppresses de novo lipogenesis (Fasn, Acc, Scd‐
Xiang Wei, Li Lin, Xiuyun Wang, Hui Du, Menglong Zhang, Kechao Tang, Han Gao, Xinrui Xie, Jingya Gao, Xu Wang, Zhenglin Wang, Siwei Huang, Lei Zhang, Fang Gu, Gong‐Hong Wei, Yinliang Qi, Wei Chen, Yongsheng Chang, Huabing Zhang   +18 more
wiley   +1 more source

Abnormalities in insulin secretion in healthy offspring of Indian patients with maturity-onset diabetes of the young [PDF]

, 1986
Serum C-peptide (CP) and immunoreactive insulin (IRI) responses were studied in 47 euglycemic offspring of patients with maturity-onset diabetes of the young (MODY).
Mohan, V., Viswanathan, M., Snehalatha, C., Ramachandran, A.   +3 more
core   +1 more source

Molecular genetics of maturity-onset diabetes of the young [PDF]

Терапевтический архив, 2016
To verify the type of diabetes mellitus (DM) remains an extremely important problem in endocrinology, as along with types 1 and 2 DM there are rarer hereditary types of DM, including maturity-onset diabetes of the young (MODY).
M I Voevoda, A A Ivanova, E V Shakhtshneider, A K Ovsyannikova, S V Mikhailova, K S Astrakova, S M Voevoda, O D Rymar   +7 more
doaj  

Chinese Expert Consensus on the Clinical Application of Finerenone in Geriatric Comorbidities

AGING MEDICINE, EarlyView.
Mineralocorticoid receptor (MR) overactivation drives inflammation, oxidative stress, and fibrosis in the heart, kidneys, and vasculature, leading to cardiorenal dysfunction. MR signaling promotes hypertrophy, remodeling, and injury through pathways like oxidative stress and inflammation, resulting in vascular stiffness and progressive organ damage ...
Xiaoming Wang, Cuntai Zhang
wiley   +1 more source

A Case of Novel Mutation of HNF1B in Maturity-onset Diabetes of the Young Type 5 (MODY5)

, 2012
Maturity-onset diabetes of the young (MODY) is both a genetically and clinically heterozygous type of diabetes mellitus characterized by early onset (often before 25 ...
Hitomi Sano, Wakako Jo, Toshihiro Tajima, Nobuaki Kawamura, Akira Sudo, Yukiko Matsunami   +5 more
core  

Genetic Testing of Maturity-Onset Diabetes of the Young Current Status and Future Perspectives

Frontiers in Endocrinology, 2018
Diabetes is a global epidemic problem growing exponentially in Asian countries posing a serious threat. Among diabetes, maturity-onset diabetes of the young (MODY) is a heterogeneous group of monogenic disorders that occurs due to β cell dysfunction ...
Parveena Firdous, Kamran Nissar, Sajad Ali, Bashir Ahmad Ganai, Uzma Shabir, Toyeeba Hassan, Shariq Rashid Masoodi   +6 more
doaj   +1 more source

Reproductive stages in lowbush blueberry (Vaccinium angustifolium) occur earlier with increasing temperature

American Journal of Botany, EarlyView.
Abstract Premise Climate change is altering the timing of many plant phenological events, yet most studies focus on flowering, with less attention given to later reproductive stages such as fruit development and ripening. Vaccinium angustifolium (lowbush blueberry) is an important perennial berry species that may be sensitive to these changes.
Jenna Floyd, Elise Cadiou, Alain G. Belliveau, Zoe A. Panchen, Terrell T. Roulston, Zoë Migicovsky   +5 more
wiley   +1 more source

A narrative insight to maturity-onset diabetes of the young

, 2020
The pandemic of metabolic disorders is accelerating in the urbanized world posing huge burden to health and economy. The key pioneer to most of the metabolic disorders is insulin dependent diabetes mellitus or Type 1 diabetes mellitus (T1DM) and non ...
Attiya Kanwal, Sahar Fazal, Nighat Naureen, Muhammad Ismail   +3 more
core  

Targeted next generation sequencing in patients with maturity-onset diabetes of the young (MODY)

, 2018
Background: Maturity-onset diabetes of the young (MODY) is a common form of monogenic diabetes. Fourteen genes have been identified, each leading to cause a different type of MODY.
Koc, Altug, Ozyilmaz, Berk, ABACI, AYHAN, Acar, Sezer, Ozdemir, Taha R., ÇATLI, GÖNÜL, DÜNDAR, BUMİN NURİ, Kaya, Ozge O., Kirbiyik, Ozgur, Guvenc, Merve S., Kutbay, Yasar B., Erdogan, Kadri M.   +11 more
core   +1 more source

Maturity-onset diabetes of the young: Different diabetes in an infant with cystic fibrosis

, 2020
Cystic fibrosis (CF) is one of the most common autosomal recessive and multisystemic diseases. CF affects many systems. One of these systems is the endocrine and exocrine functions of the pancreas, causing cystic fibrosis-related diabetes, which is ...
Melih Hangül, Mehmet Köse, Nihal Hatipoğlu, KÖSE, MEHMET, Erdogan, Murat, Murat Erdoğan, HATİPOĞLU, NİHAL, Hangul, Melih   +7 more
core   +1 more source