Results 151 to 160 of about 185,337,068 (295)

High‐Sugar Diet and Intestinal Diseases: A Shared Microbiota–Barrier–Immunity–Metabolism Axis in Inflammatory Bowel Disease, Food Allergy, and Colorectal Cancer

iNew Medicine, EarlyView.
ABSTRACT The global incidence of intestinal diseases—including food allergy, inflammatory bowel disease (IBD), and colorectal cancer (CRC)—continues to escalate in parallel with the expansion of the “Western diet,” within which the high‐sugar diet (HSD) has emerged as a pivotal yet under‐recognized dietary driver.
Yuchen Wang, Yajuan Wu, Huayang Sheng, Shouhong Jiang, Jinping Cheng, Ye Kuang, Miao Liu, Lei Feng, Yanan Sun, Jinzhi Duan   +9 more
wiley   +1 more source

Geriatric Regenerative Medicine: Mechanisms, Strategies, and Clinical Translation

iNew Medicine, EarlyView.
The pathological drivers of aging—stem cell exhaustion, cellular senescence with SASP, and aged extracellular matrix—are precisely targeted by three corresponding mechanism‐based strategies: stem cell therapies (rejuvenation, regeneration, and replacement), senolytic/senomorphic agents (D + Q, fisetin, vaccines, and CAR‐T), and senescence‐targeting ...
Qiang Li, Chaoyang Wang, Junci Chong, Zishu Liu, Boying Wang, Shiyu Liu, Xingcai Zhang, Hengrui Liu, Shuanglin Qin, ChuTse Wu, Beidong Chen, Zhigang Chang   +11 more
wiley   +1 more source

Maturity onset diabetes of the young: clinical characteristics, diagnosis and management.

, 2016
Maturity Onset Diabetes of the Young (MODY), represents a rare cause of diabetes (1% of all cases), commonly misdiagnosed as Type 1 Diabetes (T1D) or Type 2 Diabetes (T2D). Clinical characteristics of MODY include age of onset before 45 years, absence of

core  

Successful discontinuation of insulin treatment after gestational diabetes is shown to be a case of MODY due to a glucokinase mutation

Open Medicine, 2008
Talapatra Indrajit, Kalavalapalli Shyam, Robinson Jonathan, Ellard Sian, Tymms David   +4 more
doaj   +1 more source

Growing Through It: A Longitudinal Examination of Body Dissatisfaction, Mental Health, and Resilience During Adolescence

Journal of Adolescence, EarlyView.
ABSTRACT Introduction Research indicates adolescence, specifically puberty, is a critical period of psychological and physiological development. It is well known that body image is a key aspect of developmental psychology impacting mental health. Yet little is known about the buffering effects of resilience to moderate the relationship between body ...
Tiffany M. Stewart, Nicole Y. Wesley, Stephanie Broyles, Felicia Chaisson, Kelsey A. Varzeas, Amanda E. Staiano   +5 more
wiley   +1 more source

Prediction of maturity-onset diabetes of the young subtypes using machine learning. [PDF]

Front Digit Health
Figueroa I, Flores R, Millán A, de Dios A, Frechtel GD, López AP, Mennickent D.   +6 more
europepmc   +1 more source

The role of rare copy number variants in early‐onset depression

JCPP Advances, EarlyView.
Abstract Background Depression is a highly heterogeneous condition. Depression with an onset in childhood and early adolescence has a worse clinical course, is more heritable, and shows a lower genetic correlation with other depression subtypes, than does later‐onset depression.
Charlotte A. Dennison, Ida Sønderby, Miguel Garcia‐Argibay, Victoria Powell, Amy Shakeshaft, Lucy Riglin, Elliott Rees, Michael O’Donovan, Henrik Larsson, Ole Andreassen, Alexandra Havdahl, Joanna Martin, Anita Thapar   +12 more
wiley   +1 more source

Phenotypic heterogeneity and polygenic risk scores in a family of maturity-onset diabetes of the young. [PDF]

JCEM Case Rep
Chatchomchuan W, Thewjitcharoen Y, Nakasatien S, Himathongkam T, Lim CKP, Chan JCN.   +5 more
europepmc   +1 more source

Nutritional and environmental determinants of maturation and disruption of the early life gut microbiome: A narrative review

Journal of Parenteral and Enteral Nutrition, EarlyView.
Abstract The first 1000 days of life represent a critical window for gut microbiome assembly, with lifelong implications for child growth, immune development, and disease risk. This review synthesizes evidence on maternal, perinatal, and especially nutritional factors that influence early‐life intestinal colonization and highlights the consequences of ...
Carly Burow, Romy Shenderey, Fariha Chowdhury, Nyah Shah, Nikhil Pai   +4 more
wiley   +1 more source

Identification and functional characterization of a novel mutation in the NEUROD1 gene in a Chinese family with maturity-onset diabetes of the young. [PDF]

Acta Diabetol
Li J, Zhang J, Ren S, Liu Y, Wu C, Dong J, Zhu C, Chen S, Zhang H, Li T, Jiang Y.   +10 more
europepmc   +1 more source