Results 81 to 90 of about 5,237 (222)

Virucidal activity of proanthocyanidin against Mayaro virus

Antiviral Research, 2019
Mayaro virus (MAYV) is a sublethal arbovirus transmitted by mosquitoes with possible installation of an urban cycle in the Americas. Its infection causes disabling arthralgia, and still, there is no vaccine or treatment to it. We recently investigated nearly 600 compounds by molecular docking and identified epicatechin as a potent antiviral against ...
Vanessa Gonçalves Rodrigues, Sidney A. Vieira-Filho, Thaís de Fátima Silva Moraes, Jaqueline Maria Siqueira Ferreira, Cintia Lopes de Brito Magalhães, Antônio Helvécio Tótola, Lucienir Pains Duarte, José Carlos de Magalhães, Ariane Coelho Ferraz, Waleska Stephanie da Cruz Nizer, Michelli dos Santos   +10 more
openaire   +3 more sources

Experimental Transmission of Mayaro Virus by Aedes aegypti [PDF]

The American Society of Tropical Medicine and Hygiene, 2011
Outbreaks of Mayaro fever have been associated with a sylvatic cycle of Mayaro virus (MAYV) transmission in South America. To evaluate the potential for a common urban mosquito to transmit MAYV, laboratory vector competence studies were performed with Aedes aegypti from Iquitos, Peru. Oral infection in Ae.
Nicole Hausser, Stephen Higgs, Tadeusz J. Kochel, Sarah A. Ziegler, Saravanan Thangamani, Robert B. Tesh, Kanya C. Long   +6 more
openaire   +3 more sources

A Novel Self‐Amplifying mRNA with Decreased Cytotoxicity and Enhanced Protein Expression by Macrodomain Mutations

Advanced Science, Volume 11, Issue 43, November 20, 2024.
This research shows an example that reducing innate immunogenicity to increase payload protein expression of self‐amplifying RNA via a single mutation in the macrodomain. The mutant saRNA attenuates the activation of the double‐stranded RNA sensor as well as the downstream interferon response.
Yue Gong, Danni Yong, Gensheng Liu, Jiang Xu, Jun Ding, William Jia   +5 more
wiley   +1 more source

Mayaro Virus Induction of Oxidative Stress is Associated With Liver Pathology in a Non-Lethal Mouse Model

Scientific Reports, 2019
Mayaro virus (MAYV) causes Mayaro fever in humans, a self-limiting acute disease, with persistent arthralgia and arthritis. Although MAYV has a remerging potential, its pathogenic mechanisms remain unclear.
Camila Carla da Silva Caetano, Fernanda Caetano Camini, Letícia Trindade Almeida, Ariane Coelho Ferraz, Tales Fernando da Silva, Rafaela Lameira Souza Lima, Mayara Medeiros de Freitas Carvalho, Thalles de Freitas Castro, Cláudia Martins Carneiro, Breno de Mello Silva, Silvana de Queiroz Silva, José Carlos de Magalhães, Cintia Lopes de Brito Magalhães   +12 more
doaj   +1 more source

Cryo-EM structure of the mature and infective Mayaro virus at 4.4 Å resolution reveals features of arthritogenic alphaviruses

Nature Communications, 2021
Mayaro virus (MAYV) is an emerging arbovirus in Central and South America that is transmitted by mosquitoes and causes arthritogenic disease. Here, the authors present the 4.4 Å resolution cryo-EM structure of MAYV and describe specific features of the ...
Helder V. Ribeiro-Filho, Lais D. Coimbra, Alexandre Cassago, Rebeca P. F. Rocha, João Victor da Silva Guerra, Rafael de Felicio, Carolina Moretto Carnieli, Luiza Leme, Antonio Cláudio Padilha, Adriana F. Paes Leme, Daniela B. B. Trivella, Rodrigo Villares Portugal, Paulo Sérgio Lopes-de-Oliveira, Rafael Elias Marques   +13 more
doaj   +1 more source

Deltas: New paradigms

The Depositional Record, Volume 10, Issue 5, Page 600-636, November 2024.
This paper discusses some new paradigms concerning the origin and significance of deltas and their deposits. It proposes a broader definition of deltas that takes into account the importance of sediment‐laden fluvial discharges in controlling deltaic sedimentation.
Carlos Zavala, Mariano Arcuri, Agustin Zorzano, Valentín Trobbiani, Antonela Torresi, Ainara Irastorza   +5 more
wiley   +1 more source

Obesity's Unexpected Influence: Reduced Alphavirus Transmission and Altered Immune Activation in the Vector

Journal of Medical Virology, Volume 96, Issue 11, November 2024.
ABSTRACT Chikungunya virus (CHIKV) and Mayaro virus (MAYV) are emerging/re‐emerging alphaviruses transmitted by Aedes spp. mosquitoes and responsible for recent disease outbreaks in the Americas. The capacity of these viruses to cause epidemics is frequently associated with increased mosquito transmission, which in turn is governed by virus−host−vector
Pallavi Rai, Emily M. Webb, Sally L. Paulson, Lin Kang, James Weger‐Lucarelli   +4 more
wiley   +1 more source

The NLRP3 inflammasome is involved with the pathogenesis of Mayaro virus

PLOS Pathogens, 2019
Mayaro virus (MAYV) is an arbovirus that circulates in Latin America and is emerging as a potential threat to public health. Infected individuals develop Mayaro fever, a severe inflammatory disease characterized by high fever, rash, arthralgia, myalgia and headache.
Luiza A. de Castro-Jorge, Renan V. H. de Carvalho, Taline M. Klein, Carlos H. Hiroki, Alexandre H. Lopes, Rafaela M. Guimarães, Marcílio Jorge Fumagalli, Vitor G. Floriano, Mayara R. Agostinho, Renata Dezengrini Slhessarenko, Fernando Silva Ramalho, Thiago M. Cunha, Fernando Q. Cunha, Benedito A. L. da Fonseca, Dario S. Zamboni   +14 more
openaire   +4 more sources

Genetic analysis of members of the species Oropouche virus and identification of a novel M segment sequence [PDF]

, 2015
Oropouche virus (OROV) is a public health threat in South America, and in particular Northern Brazil, causing frequent outbreaks of febrile illness.
Azevedo, Raimunda S.S., da Silva, Daisy E.A., Elliott, Richard M., Hughes, Joseph, Nunes, Marcio R.T., Olszanski Acrani, Gustavo, Rodrigues, Sueli G., Tilston-Lunel, Natasha L., Vasconcelos, Pedro F.C.   +8 more
core   +1 more source

Applications and advancements in animal models for antiviral research on mosquito‐borne arboviruses

Animal Models and Experimental Medicine, Volume 7, Issue 5, Page 673-684, October 2024.
Animal models are crucial in antiviral research on mosquito‐borne arboviruses, playing a role in understanding disease mechanisms, vaccine development, and toxicity testing. The use of animal models confronts hurdles related to ethical considerations and the successful translation of findings from animals to humans.
Megan Caifeng Tang, Ka Heng Wong, Adzzie Shazleen Azman, Rafidah Lani   +3 more
wiley   +1 more source