Results 221 to 230 of about 19,208 (245)

Red hair is the null phenotype of MC1R

Human Mutation, 2008
The Melanocortin-1 Receptor (MC1R) is a G-protein coupled receptor, which is responsible for production of the darker eumelanin pigment and the tanning response. The MC1R gene has many polymorphisms, some of which have been linked to variation in pigmentation phenotypes within human populations.
Beaumount, Kimberley, Shekar, Sri, Cook, Anthony, Duffy, David, Sturm, Richard A.   +4 more
openaire   +3 more sources

Discovery of a new nucleotide substitution in the MC1R gene and haplotype distribution in native and non-Japanese chicken breeds.

Animal Genetics, 2020
Melanocortin 1-receptor (MC1R) is one of the major genes that controls chicken plumage colour. In this study, we investigated the sequence and haplotype distribution of the MC1R gene in native Japanese chickens, along with non-Japanese chicken breeds. In
M. H. Kabir, A. Takenouchi, M. I. Haqani, Y. Nakamura, S. Takeuchi, M. Tsudzuki   +5 more
semanticscholar   +1 more source

Melanocortin-1 receptor (MC1R): a review for dermatologists

Italian Journal of Dermatology and Venereology
Melanocortin-1 receptor (MC1R) and its variants have a pivotal role in melanin synthesis. However, MC1R has been associated to non-pigmentary pathways related to DNA-repair activities and inflammation. The aim of this review is to provide an up-to-date overview about the role of MC1R in the skin.
Guida S., Puig S., Di Resta C., Sallustio F., Mangano E., Stabile G., Longo C., Pellacani G., Guida G., Rongioletti F.   +9 more
openaire   +5 more sources

[MC1R polymorphisms and facial photoaging].

Annales de dermatologie et de venereologie, 2011
The objective of this study was to assess the association between melanocortin-1 receptor (MC1R) variants and the severity of facial skin photoaging.The study population comprised 530 French middle-aged women between 44 and 70 years. A trained dermatologist graded the severity of facial skin photoaging from photographs using Larnier's global scale ...
J, Latreille, K, Ezzedine, A, Elfakir, L, Ambroisine, R, Jdid, P, Galan, S, Hercberg, F, Gruber, D, Malvy, E, Tschachler, C, Guinot   +10 more
openaire   +1 more source

The role of MC1R gene in buffalo coat color

Science China Life Sciences, 2010
Melanocortin-1 receptor (MC1R) plays a major role in pigmentation in many species. To investigate if the MC1R gene is associated with coat color in water buffalo, the coding region of MC1R gene of 216 buffalo samples was sequenced, which included 49 black river buffalo (Murrah and Nili-Ravi), 136 swamp buffalo (Dehong, Diandongnan, Dechang, Guizhou ...
YongWang, Miao, GuiSheng, Wu, Lei, Wang, DaLin, Li, ShouKun, Tang, JianPing, Liang, HuaMing, Mao, HuaiRong, Luo, YaPing, Zhang   +8 more
openaire   +2 more sources

Polymorphismes du MC1R et photovieillissement du visage

Annales de Dermatologie et de Vénéréologie, 2011
Resume Introduction L’objectif de cette etude etait d’evaluer l’impact du polymorphisme du gene du recepteur de la melanocortine-1 (MC1R) sur la severite du photovieillissement du visage. Methodes Cinq cent trente femmes residant en ile-de-France, âgees de 44 a 70 ans, ont participe a l’etude.
J. Latreille, K. Ezzedine, A. Elfakir, L. Ambroisine, R. Jdid, P. Galan, S. Hercberg, F. Gruber, D. Malvy, E. Tschachler, C. Guinot   +10 more
openaire   +1 more source

Is MC1R involved in swine melanoma : analysis of MC1R alleles in MeLiM families?

2004
International ...
Créchet, Francoise, Du, Zhi Qiang, Vincent-Naulleau, Silvia, Arnaudeau-Begard, C., Le Roy, Pascale, Frelat, G., Geffrotin, Claudine   +6 more
openaire   +2 more sources

High naevus count and MC1R red hair alleles contribute synergistically to increased melanoma risk

British Journal of Dermatology, 2019
A high total body naevus count is the highest risk factor for melanoma; the phenotype of red hair colour, freckling and pale skin that burns easily, produced by MC1R R alleles, also predisposes to melanoma.
David L Duffy, David L Duffy, Katie J Lee, K. Jagirdar, A. Pflugfelder, M. Stark, E. McMeniman, E. McMeniman, H. Soyer, H. Soyer, Richard A. Sturm   +10 more
semanticscholar   +1 more source

MC1R variant alleles and malignant melanoma risk in Israel

European Journal of Cancer, 2009
To evaluate the contribution of MC1R variants to malignant melanoma risk in Israeli Jews, sequencing of the MC1R gene was performed in 132 melanoma patients and 184 ethnically matched controls. Overall, 22 MC1R variants were detected, two were novel (M73I and 496_497insG).
Gilli, Galore-Haskel, Esther, Azizi, Hamida, Mohamdi, Alon, Scope, Valérie, Chaudru, Yael, Laitman, Frida, Barak, Felix, Pavlotsky, Florence, Demenais, Eitan, Friedman   +9 more
openaire   +2 more sources

The influence of MC1R on dermal morphological features of photo‐exposed skin in women revealed by reflectance confocal microscopy and optical coherence tomography

Experimental Dermatology, 2019
The melanocortin 1 receptor (MC1R) gene is one of the major determinants of skin pigmentation. It is a highly polymorphic gene and some of its polymorphisms have been related to specific skin phenotypes, increased risk of skin cancers and skin ...
S. Guida, S. Ciardo, B. De Pace, N. De Carvalho, F. Peccerillo, M. Manfredini, F. Farnetani, J. Chester, S. Kaleci, M. Manganelli, G. Guida, G. Pellacani   +11 more
semanticscholar   +1 more source