Differential Effects of Quercetin and Two of Its Derivatives, Isorhamnetin and Isorhamnetin-3-glucuronide, in Inhibiting the Proliferation of Human Breast-Cancer MCF-7 Cells. [PDF]
Journal of Agricultural and Food Chemistry, 2018 Quercetin (Que) has consistently been reported to be useful cytotoxic compound in vivo and in vitro, but little is known on its metabolites. Here, we examined and compared the cytotoxic effects of Que and its water-soluble metabolites, isorhamnetin (IS ...
Qiu Wu +4 more
semanticscholar +3 more sources
Preliminary Investigation of Myo-Inositol Phosphates Produced by ASUIA279 Phytase on MCF-7 Cancer Cells [PDF]
International Islamic University Malaysia Engineering Journal, 2011 Phytate or myo-inositol hexakisphosphates (IP6) is widely distributed in plants like rice brans. The production of myo-inositol phosphate intermediates has received much attention due to the remarkable potential health benefits offered by the compounds ...
N. Mohd. Yusoff +7 more
doaj +3 more sources
Unfermented Freeze-Dried Leaf Extract of Tongkat Ali (Eurycoma longifolia Jack.) Induced Cytotoxicity and Apoptosis in MDA-MB-231 and MCF-7 Breast Cancer Cell Lines [PDF]
, 2021 possible anticancer mechanism of action against breast cancer cell lines: non-hormone-dependent MDA-MB-231 and hormonedependent MCF-7. -e leaves of E.
Abdul Aziz, Zaleha +3 more
core +1 more source
Tamoxifen induces ferroptosis in MCF-7 organoid
Journal of Cancer Research and Therapeutics, 2023 Background: Breast cancer is the most common female malignant tumor type globally. The occurrence and development of breast cancer involve ferroptosis, which is closely related to its treatment. The development of breast cancer organoids facilitates the analysis of breast cancer molecular background and tumor biological ...
Lei, Ye +6 more
openaire +2 more sources
Coenzyme Q Depletion Reshapes MCF-7 Cells Metabolism [PDF]
International Journal of Molecular Sciences, 2020 Mitochondrial dysfunction plays a significant role in the metabolic flexibility of cancer cells. This study aimed to investigate the metabolic alterations due to Coenzyme Q depletion in MCF-7 cells. Method: The Coenzyme Q depletion was induced by competitively inhibiting with 4-nitrobenzoate the coq2 enzyme, which catalyzes one of the final reactions ...
Wang W. +6 more
openaire +4 more sources
Potential Therapeutic Effect of Natural Killer Cells on Doxorubicin-Resistant Breast Cancer Cells In Vitro. [PDF]
PLoS ONE, 2015 The aim of this study was to explore the therapeutic effect of natural killer (NK) cells on human doxorubicin-sensitive and resistant breast adenocarcinoma.Human doxorubicin-sensitive and resistant breast cancer cell lines (MCF-7 and MCF-7/ADR) were ...
Mi-Hye Hwang +6 more
doaj +1 more source
Nutrients, 2020 Saturated fatty acids possess few health benefits compared to unsaturated fatty acids. However, increasing experimental evidence demonstrates the nutritionally beneficial role of odd-chain saturated fatty acids in human health.
Ngoc Bao To +4 more
semanticscholar +1 more source
Downregulation of Choline Kinase-Alpha Enhances Autophagy in Tamoxifen-Resistant Breast Cancer Cells. [PDF]
PLoS ONE, 2015 Choline kinase-α (Chk-α) and autophagy have gained much attention, as they relate to the drug-resistance of breast cancer. Here, we explored the potential connection between Chk-α and autophagy in the mechanisms driving to tamoxifen (TAM) resistance, in ...
Hoe Suk Kim +6 more
doaj +1 more source
Secondary metabolites, antioxidant, and antiproliferative activities of Dioscorea bulbifera Leaf Collected from Endau Rompin, Johor, Malaysia [PDF]
, 2021 Breast cancer is among the most commonly diagnosed cancer and the leading cause of cancer-related death among women globally. Malaysia is a country that is rich in medicinal plant species. Hence, this research aims to explore the secondary metabolites,
Abu Bakar, Fazleen Izzany +5 more
core +1 more source
5-(carbamoylmethylene)-oxazolidin-2-ones as a promising class of heterocycles inducing apoptosis triggered by increased ROS levels and mitochondrial dysfunction in breast and cervical cancer [PDF]
, 2020 Oxazolidinones are antibiotics that inhibit protein synthesis by binding the 50S ribosomal subunit. Recently, numerous worldwide researches focused on their properties and possible involvement in cancer therapy have been conducted.
Armentano, B +10 more
core +2 more sources