Overexpression of TMEM47 Induces Tamoxifen Resistance in Human Breast Cancer Cells
Technology in Cancer Research & Treatment, 2021 Background: Tamoxifen (TAM) is the eminent first-line drug for endocrine therapy of hormone receptor positive premenopausal breast cancer and reduces the risk of recurrence by ∼50%.
Xin Men +6 more
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Effects of silencing Ki-67 gene on doxorubicin resistance of breast cancer MCF-7/DOX cells [PDF]
Waike lilun yu shijian, 2023 Objective To study the effect of Ki-67 gene silencing on doxorubicin (DOX) resistance in breast cancer MCF-7 cells. Methods Liposome transient transfection method and breast cancer MCF-7 cells cultured in vitro were used combined with the transfection of
DONG Jun, CUI Fengming, LIU Jun
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Indonesian Journal of Biotechnology, 2012 The long-term exposure of doxorubicin (Dox) causes enhancement in MDR1 expression that leads to breast cancer cell resistance. This protein become a serious problem in cancer treatment and also well-known as negative prognostic factor in breast cancer ...
Nunuk Aries Nurulita +3 more
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The small heat shock protein B8 (HSPB8) modulates proliferation and migration of breast cancer cells [PDF]
, 2017 open12noBreast cancer (BC) is one of the major causes of cancer death in women and is closely related to hormonal dysregulation. Estrogen receptor (ER)-positive BCs are generally treated with anti hormone therapy using antiestrogens or aromatase ...
CARRA, Serena +11 more
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MCF-7 and its Multidrug Resistant Variant MCF-7/ADR Overcome TNF Cytotoxicity through Prevention of Reactive Oxygen Species Accumulation [PDF]
Pharmaceutical Sciences, 2019 Background: Signal transduction of numerous cytokines and growth factors are mediated by reactive oxygen species (ROS). Tumor necrosis factor-α (TNF-α) have stimulated accumulation of ROS in various in vitro studies.
Morteza Ghandadi +4 more
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β-diketonate versus β-ketoiminate:the importance of a ferrocenyl moiety on improving the anticancer potency [PDF]
, 2020 Herein we present a library of fully characterized beta-diketonate and beta-ketoiminate compounds that are functionalized with a ferrocenyl moiety. Their cytotoxic potential has been determined by screening against human breast adenocarcinomas (MCF-7 and
Allison, Matthew +4 more
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Overexpression of microRNA-16 declines cellular growth, proliferation and induces apoptosis in human breast cancer cells [PDF]
, 2015 MicroRNAs (miRNA) are a large family of small single-stranded RNA molecules found in all multicellular organisms. Early studies have been shown that miRNA are involved in cancer development and progression, and this role can be done by working as an ...
Hafizi, M. +8 more
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Genistein-induced mir-23b expression inhibits the growth of breast cancer cells [PDF]
, 2015 Aim of the study: Genistein, an isoflavonoid, plays roles in the inhibition of protein tyrosine kinase phosphorylation, induction of apoptosis, and cell differentiation in breast cancer.
Avci, C.B. +6 more
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Role of insulin-like growth factor binding protein-3 in 1, 25-dihydroxyvitamin-d 3 -induced breast cancer cell apoptosis. [PDF]
, 2013 Insulin-like growth factor I (IGF-I) is implicated in breast cancer development and 1, 25-dihydroxyvitamin D3 (1, 25-D3) has been shown to attenuate prosurvival effects of IGF-I on breast cancer cells.
Brosseau, C, Colston, KW, Pirianov, G
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Aberrant N-glycolylneuraminic acid in breast MCF-7 cancer cells and cancer stem cells
Frontiers in Molecular Biosciences, 2022 N-Glycolylneuraminic acid (Neu5Gc) is not normally detected in humans because humans lack the hydroxylase enzyme that converts cytidine-5′-monophosphate-N-acetylneuraminic acid (CMP-Neu5Ac) to CMP-Neu5Gc; thus, any Neu5Gc appearing in the human body is ...
Wenqian Yang +4 more
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