β-diketonate versus β-ketoiminate:the importance of a ferrocenyl moiety on improving the anticancer potency [PDF]
, 2020 Herein we present a library of fully characterized beta-diketonate and beta-ketoiminate compounds that are functionalized with a ferrocenyl moiety. Their cytotoxic potential has been determined by screening against human breast adenocarcinomas (MCF-7 and
Allison, Matthew +4 more
core +2 more sources
Tamoxifen induces ferroptosis in MCF-7 organoid
Journal of Cancer Research and Therapeutics, 2023 Background: Breast cancer is the most common female malignant tumor type globally. The occurrence and development of breast cancer involve ferroptosis, which is closely related to its treatment. The development of breast cancer organoids facilitates the analysis of breast cancer molecular background and tumor biological ...
Lei, Ye +6 more
openaire +2 more sources
Coenzyme Q Depletion Reshapes MCF-7 Cells Metabolism [PDF]
International Journal of Molecular Sciences, 2020 Mitochondrial dysfunction plays a significant role in the metabolic flexibility of cancer cells. This study aimed to investigate the metabolic alterations due to Coenzyme Q depletion in MCF-7 cells. Method: The Coenzyme Q depletion was induced by competitively inhibiting with 4-nitrobenzoate the coq2 enzyme, which catalyzes one of the final reactions ...
Wang W. +6 more
openaire +4 more sources
Potential Therapeutic Effect of Natural Killer Cells on Doxorubicin-Resistant Breast Cancer Cells In Vitro. [PDF]
PLoS ONE, 2015 The aim of this study was to explore the therapeutic effect of natural killer (NK) cells on human doxorubicin-sensitive and resistant breast adenocarcinoma.Human doxorubicin-sensitive and resistant breast cancer cell lines (MCF-7 and MCF-7/ADR) were ...
Mi-Hye Hwang +6 more
doaj +1 more source
Downregulation of Choline Kinase-Alpha Enhances Autophagy in Tamoxifen-Resistant Breast Cancer Cells. [PDF]
PLoS ONE, 2015 Choline kinase-α (Chk-α) and autophagy have gained much attention, as they relate to the drug-resistance of breast cancer. Here, we explored the potential connection between Chk-α and autophagy in the mechanisms driving to tamoxifen (TAM) resistance, in ...
Hoe Suk Kim +6 more
doaj +1 more source
Secondary metabolites, antioxidant, and antiproliferative activities of Dioscorea bulbifera Leaf Collected from Endau Rompin, Johor, Malaysia [PDF]
, 2021 Breast cancer is among the most commonly diagnosed cancer and the leading cause of cancer-related death among women globally. Malaysia is a country that is rich in medicinal plant species. Hence, this research aims to explore the secondary metabolites,
Abu Bakar, Fazleen Izzany +5 more
core +1 more source
IGF-1 regulates Cyr61 induced breast cancer cell proliferation and invasion. [PDF]
, 2014 BackgroundStudies from our laboratory and others have shown that cysteine-rich 61 (Cyr61) may be involved in tumor proliferation and invasion. In earlier studies, we demonstrated increased insulin-like growth factor-I (IGF-1) is associated with breast ...
Cardenas, Jessica +5 more
core +6 more sources
Indonesian Journal of Biotechnology, 2012 The long-term exposure of doxorubicin (Dox) causes enhancement in MDR1 expression that leads to breast cancer cell resistance. This protein become a serious problem in cancer treatment and also well-known as negative prognostic factor in breast cancer ...
Nunuk Aries Nurulita +3 more
doaj +1 more source
Role of insulin-like growth factor binding protein-3 in 1, 25-dihydroxyvitamin-d 3 -induced breast cancer cell apoptosis. [PDF]
, 2013 Insulin-like growth factor I (IGF-I) is implicated in breast cancer development and 1, 25-dihydroxyvitamin D3 (1, 25-D3) has been shown to attenuate prosurvival effects of IGF-I on breast cancer cells.
Brosseau, C, Colston, KW, Pirianov, G
core +2 more sources
Overexpression of TMEM47 Induces Tamoxifen Resistance in Human Breast Cancer Cells
Technology in Cancer Research & Treatment, 2021 Background: Tamoxifen (TAM) is the eminent first-line drug for endocrine therapy of hormone receptor positive premenopausal breast cancer and reduces the risk of recurrence by ∼50%.
Xin Men +6 more
doaj +1 more source