Results 41 to 50 of about 5,865,115 (353)

Platelets promote breast cancer cell MCF-7 metastasis by direct interaction: surface integrin α2β1-contacting-mediated activation of Wnt-β-catenin pathway

Cell Communication and Signaling, 2019
Integrin-mediated platelet-tumor cell contacting plays an important role in promoting epithelial-mesenchymal transition (EMT) transformation of tumor cells and cancer metastasis, but whether it occurs in breast cancer cells is not completely clear.
X. Zuo, Ya Yang, Yue Zhang, Zhi-gang Zhang, Xiao-fei Wang, Yong-gang Shi   +5 more
semanticscholar   +1 more source

Cyperotundone combined with adriamycin induces apoptosis in MCF-7 and MCF-7/ADR cancer cells by ROS generation and NRF2/ARE signaling pathway

Scientific Reports, 2023
Breast cancer has become the most prevalent cancer, globally. Adriamycin is a first-line chemotherapeutic agent, however, cancer cells acquire resistance to it, which is one of the most common causes of treatment failure.
Wenna Shao, Xinzhao Wang, Zhaoyun Liu, Xiang Song, Fukai Wang, Xiaoyu Liu, Zhiyong Yu   +6 more
doaj   +1 more source

β-Elemene Reverses Chemoresistance of Breast Cancer via Regulating MDR-Related MicroRNA Expression

Cellular Physiology and Biochemistry, 2014
Background: Multidrug resistance (MDR) directly contributes to the clinical failure of chemotherapy in breast cancer (BCA). β-elemene is a natural antitumor drug from plants. We previously confirmed that MDR could be reversed by β-elemene. In this study,
Jun Zhang, He da Zhang, Lin Chen, Da Wei Sun, Chang fei Mao, Wei Chen, Jian Zhong Wu, Shan liang Zhong, Jian Hua Zhao, Jin Hai Tang   +9 more
doaj   +1 more source

Combination therapy with miR34a and doxorubicin synergistically inhibits Dox-resistant breast cancer progression via down-regulation of Snail through suppressing Notch/NF-κB and RAS/RAF/MEK/ERK signaling pathway

Acta Pharmaceutica Sinica B, 2021
Resistance to breast cancer (BCa) chemotherapy severely hampers the patient's prognosis. MicroRNAs provide a potential therapeutic prospect for BCa. In this study, the reversal function of microRNA34a (miR34a) on doxorubicin (Dox) resistance of BCa and ...
Xiaoxia Yang, Pengfei Shang, Bingfang Yu, Qiuyang Jin, Jing Liao, Lei Wang, Jianbo Ji, Xiuli Guo   +7 more
doaj   +1 more source

Comparative proteomics study of proteins involved in induction of higher rates of cell death in mitoxantrone-resistant breast cancer cells MCF-7/MX exposed to TNF-α [PDF]

Iranian Journal of Basic Medical Sciences, 2020
Objective(s): Resistance to medications is one of the main complications in chemotherapy of cancer. It has been shown that some multidrug resistant cancer cells indicate more sensitivity against cytotoxic effects of TNF-α compared to their parental cells.
saeed Norouzi, rezvan yazdian, Morteza Ghanaian, Khalil Abnous, Javad Behravan, Fatemeh Mosafa   +5 more
doaj   +1 more source

Cell surface binding, uptaking and anticancer activity of L-K6, a lysine/leucine-rich peptide, on human breast cancer MCF-7 cells

Scientific Reports, 2017
Cell surface binding and internalization are critical for the specific targeting and biofunctions of some cationic antimicrobial peptides (CAPs) with anticancer activities. However, the detailed cellular process for CAPs interacting with cancer cells and
Che Wang, Shao-ling Dong, Lin Zhang, Ying Zhao, Lili Huang, Xiange Gong, He Wang, D. Shang   +7 more
semanticscholar   +1 more source

17β-Estradiol responsiveness of MCF-7 laboratory strains is dependent on an autocrine signal activating the IGF type I receptor

Cancer Cell International, 2003
Background Human MCF-7 cells have been studied extensively as a model for breast cancer cell growth. Many reports have established that serum-starved MCF-7 cells can be induced to proliferate upon the sole addition of 17β-estradiol (E2).
Steenbergh Paul H, Sussenbach John S, van Schaik Richard FMA, Hamelers Irene HL   +3 more
doaj   +1 more source

Effects of bisphenol compounds on the growth and epithelial mesenchymal transition of MCF-7 CV human breast cancer cells

Journal of Biomedical Research, 2017
Bisphenol-A (BPA) has been considered as an endocrine disrupting chemical (EDC) because it can exert estrogenic properties. For bisphenol-S (BPS) and bisphenol-F (BPF) that are BPA analogs and substitutes, their risk to estrogen-dependent cancer has been
Ji-Youn Kim, Hong-Gyu Choi, Hae-Miru Lee, Geum-A Lee, Kyung-A Hwang, Kyung-Chul Choi   +5 more
semanticscholar   +1 more source

Preparation and characterization of (−)-Epigallocatechin-3-gallate (EGCG)-loaded nanoparticles and their inhibitory effects on Human breast cancer MCF-7 cells

Scientific Reports, 2017
We were employing nanotechnology to improve the targeting ability of (−)-Epigallocatechin-3-gallate (EGCG) towards MCF-7 cells, and two kinds of EGCG nanoparticles (FA-NPS-PEG and FA-PEG-NPS) were obtained, besides, their characteristics and effects on ...
L. Zeng, Jingna Yan, Liyong Luo, Mengjun Ma, Huiqun Zhu   +4 more
semanticscholar   +1 more source

Effects of HIF-2α on Biological Function of Breast Cancer MCF-7 Cells

Zhongliu Fangzhi Yanjiu, 2018
Objective To investigate the effect of HIF-2α on proliferation, invasion and colony forming abilities of breast cancer MCF-7 cells. Methods HIF-2α ORF/shRNA lentivirus vectors were transfected into MCF-7 cells respectively, and then we screened and ...
LIU Yuqiong, LI Na, HUANG Huifen, LI Huixiang   +3 more
doaj   +1 more source