Results 11 to 20 of about 106,995 (260)

Glycosaminoglycans Targeted by Colchicine in MCF-7 Cells. [PDF]

Pharmaceutics
Background: Breast cancer is the most common cancer diagnosis and the second leading cause of cancer-related death in women. Breast cancer is a major health burden worldwide. Advances in breast cancer detection and treatment have contributed to improving the rate of survival, although mortality rates remain significantly high.
Czarnecka-Czapczyńska M, Przygórzewska A, Dynarowicz K, Bartusik-Aebisher D, Aebisher D, Kawczyk-Krupka A.   +5 more
europepmc   +5 more sources

Adipose-Derived Stem Cell Features and MCF-7 [PDF]

Cells, 2021
Human adipose tissue-derived stem cells (hADSCs) are highly suitable for regeneration therapies being easily collected and propagated in vitro. The effects of different external factors and culturing conditions are able to affect hADSC proliferation, senescence, differentiation, and migration, even at the molecular level.
Giuseppe Garroni, Francesca Balzano, Sara Cruciani, Renzo Pala, Donatella Coradduzza, Emanuela Azara, Emanuela Bellu, Maria Laura Cossu, Giorgio C. Ginesu, Ciriaco Carru, Carlo Ventura, Margherita Maioli   +11 more
openaire   +7 more sources

Annexin-A5 Overexpression Increases Sensitivity of MCF-7 and MCF-7/ADR Cells to Epirubicin

Avicenna Journal of Medical Biotechnology, 2023
Background: Multi-drug resistance is an important challenge in the chemotherapy of cancer. The role of annexin A5 (ANXA5) in the biology of cancer has been the focus of many studies. Breast Cancer (BC) is frequent cancer in women with high morbidity and mortality rate.
Ghasemi, Mahshad, Reiazi, Niloofar, Behzad-Behbahani, Abbas, Takhshid, Mohammad Ali   +3 more
openaire   +2 more sources

Viability of HepG2 and MCF-7 cells is not correlated with mitochondrial bioenergetics. [PDF]

Sci Rep, 2023
ABSTRACT Alterations in metabolism is a hallmark of cancer. It is unclear, however, if oxidative phosphorylation (OXPHOS) is required for tumor cell survival. We investigated the effect of severe hypoxia, site-specific inhibition of respiratory chain (RC) components, and uncouplers on the survival of HepG2 and MCF-7 2D cultured cells ...
Doczi J, Karnok N, Bui D, Azarov V, Pallag G, Nazarian S, Czumbel B, Seyfried TN, Chinopoulos C.   +8 more
europepmc   +4 more sources

The antiproliferative potential and mechanism of action of metformin in MCF-7 cells. [PDF]

Future Sci OA, 2023
The current study aimed to investigate the potential antiproliferative activity of metformin, the effective concentration range, and the mechanism of action.Human breast cancer cells, MCF-7 were treated with a serial dilution of metformin (10-150 μM) for 24 and 48 h. Potential antiproliferative activity of metformin and its ability in inducing cellular
Bekezhankyzy Z, Nurzhan S, Berdigaliyev N, Sergazy S, Maulenkul T, Aljofan M.   +5 more
europepmc   +4 more sources

Nuclear β-catenin and CD44 upregulation characterize invasive cell populations in non-aggressive MCF-7 breast cancer cells

BMC Cancer, 2010
Background In breast cancer cells, the metastatic cell state is strongly correlated to epithelial-to-mesenchymal transition (EMT) and the CD44+/CD24- stem cell phenotype.
Uchino Masahiro, Kojima Hiroko, Wada Kenta, Imada Mika, Onoda Fumitoshi, Satofuka Hiroyuki, Utsugi Takahiko, Murakami Yasufumi   +7 more
doaj   +1 more source

TNF-α Increases IP-10 Expression in MCF-7 Breast Cancer Cells via Activation of the JNK/c-Jun Pathways

Biomolecules, 2021
IP-10 (also called CXCL10) plays a significant role in leukocyte homing to inflamed tissues, and increased IP-10 levels are associated with the pathologies of various inflammatory disorders, including type 2 diabetes, atherosclerosis, and cancer.
Shihab Kochumon, Amnah Al-Sayyar, Texy Jacob, Amal Hasan, Fahd Al-Mulla, Sardar Sindhu, Rasheed Ahmad   +6 more
doaj   +1 more source

Transcriptomic Changes in Cisplatin-Resistant MCF-7 Cells. [PDF]

Int J Mol Sci
Breast cancer is a leading cause of cancer-related deaths among women. Cisplatin is used for treatment, but the development of resistance in cancer cells is a significant concern. This study aimed to investigate changes in the transcriptomes of cisplatin-resistant MCF7 cells.
Ruiz-Silvestre A, Garcia-Venzor A, Ceballos-Cancino G, Sánchez-López JM, Vazquez-Santillan K, Mendoza-Almanza G, Lizarraga F, Melendez-Zajgla J, Maldonado V.   +8 more
europepmc   +3 more sources

Anthocyanins Isolated from Vitis coignetiae Pulliat Enhances Cisplatin Sensitivity in MCF-7 Human Breast Cancer Cells through Inhibition of Akt and NF-κB Activation

Molecules, 2020
Anthocyanins isolated from Vitis coignetiae Pulliat (Meoru in Korea) (AIMs) have various anti-cancer properties by inhibiting Akt and NF-κB which are involved in drug resistance. Cisplatin (CDDP) is one of the popular anti-cancer agents. Studies reported
Anjugam Paramanantham, Min Jeong Kim, Eun Joo Jung, Hye Jung Kim, Seong-Hwan Chang, Jin-Myung Jung, Soon Chan Hong, Sung Chul Shin, Gon Sup Kim, Won Sup Lee   +9 more
doaj   +1 more source

Combination therapy with miR34a and doxorubicin synergistically inhibits Dox-resistant breast cancer progression via down-regulation of Snail through suppressing Notch/NF-κB and RAS/RAF/MEK/ERK signaling pathway

Acta Pharmaceutica Sinica B, 2021
Resistance to breast cancer (BCa) chemotherapy severely hampers the patient's prognosis. MicroRNAs provide a potential therapeutic prospect for BCa. In this study, the reversal function of microRNA34a (miR34a) on doxorubicin (Dox) resistance of BCa and ...
Xiaoxia Yang, Pengfei Shang, Bingfang Yu, Qiuyang Jin, Jing Liao, Lei Wang, Jianbo Ji, Xiuli Guo   +7 more
doaj   +1 more source