Results 21 to 30 of about 106,995 (260)

Effects of HIF-2α on Biological Function of Breast Cancer MCF-7 Cells

Zhongliu Fangzhi Yanjiu, 2018
Objective To investigate the effect of HIF-2α on proliferation, invasion and colony forming abilities of breast cancer MCF-7 cells. Methods HIF-2α ORF/shRNA lentivirus vectors were transfected into MCF-7 cells respectively, and then we screened and ...
LIU Yuqiong, LI Na, HUANG Huifen, LI Huixiang   +3 more
doaj   +1 more source

PD-L1 CAR effector cells induce self-amplifying cytotoxic effects against target cells

Journal for ImmunoTherapy of Cancer, 2022
Background Immune checkpoint inhibitors and chimeric antigen receptor (CAR)-based therapies have transformed cancer treatment. Recently, combining these approaches into a strategy of PD-L1-targeted CAR has been proposed to target PD-L1high tumors.
Leszek Pączek, Radoslaw Zagozdzon, Karl-Johan Malmberg, Malgorzata Bajor, Agnieszka Graczyk-Jarzynka, Katsiaryna Marhelava, Anna Burdzinska, Angelika Muchowicz, Agnieszka Goral, Andriy Zhylko, Karolina Soroczynska, Kuba Retecki, Marta Krawczyk, Marta Klopotowska, Zofia Pilch, Sébastien Wälchli, Magdalena Winiarska   +16 more
doaj   +1 more source

New 3-Cyano-2-Substituted Pyridines Induce Apoptosis in MCF 7 Breast Cancer Cells

Molecules, 2016
The synthesis of new 3-cyano-2-substituted pyridines bearing various pharmacophores and functionalities at position 2 is described. The synthesized compounds were evaluated for their in vitro anti-cancer activities on five cancer cell lines using 5-FU as
Ahmed Malki, Mona Mohsen, Hassan Aziz, Ola Rizk, Omima Shaban, Mohamed El-Sayed, Zaki A. Sherif, Hayam Ashour   +7 more
doaj   +1 more source

Combination of Doxorubicin and Berberine Generated Synergistic Anticancer Effect on Breast Cancer Cells Through Down-regulation of Nanog and miRNA-21 Gene Expression

Middle East Journal of Cancer, 2020
Background: Our purpose was to investigate the effect of berberine (BER) and doxorubicin (DOX) on the expression of stem cell markers Nanog and microRNA- 21 in MCF-7 cells.
Samia A. Ebeid, Nadia A. Abd El Moneim, Hossam El-Din M. Ghoneim, Sanaa A. El-Benhawy, Samah E. Ismail   +4 more
doaj   +1 more source

Regulation of the Estrogen Receptor in MCF-7 Cells by Estradiol [PDF]

Molecular Endocrinology, 1988
The role of estradiol in the regulation of its cognate receptor in MCF-7 cells was investigated in this study. After treatment with 10(-9) M estradiol, the level of receptor protein was measured using an enzymeimmunoassay. By 6 h, the receptor protein declined by about 60% from a level of approximately 3.6 to 1.2 fmol/micrograms DNA.
M, Saceda, M E, Lippman, P, Chambon, R L, Lindsey, M, Ponglikitmongkol, M, Puente, M B, Martin   +6 more
openaire   +2 more sources

Upregulation of autophagy by Ginsenoside Rg2 in MCF-7 cells [PDF]

Animal Cells and Systems, 2018
Autophagy is a major intracellular degradation process that plays an important role in cell survival, stress responses, nutrient sensing and development. Our previous studies have shown that Rg2, a triterpenoid saponin contained in ginseng, protects cells against UVB-induced genotoxicity by increasing DNA repair, in possible association with modulation
Chung, Yuheon, Jeong, Seula, Choi, Hyun S., Ro, Seungil, Lee, Jung S., Park, Jong K.   +5 more
openaire   +4 more sources

Overexpression of Cell Surface Cytokeratin 8 in Multidrug-Resistant MCF-7/MX Cells Enhances Cell Adhesion to the Extracellular Matrix

Neoplasia: An International Journal for Oncology Research, 2008
Accumulating evidence suggests that multiple complex mechanisms may be involved, simultaneously or complementarily, in the emergence and development of multidrug resistance (MDR) in various cancers. Cell adhesion-mediated MDR is one such mechanism.
Fang Liu, Zhong Chen, Jinhong Wang, Xiaofeng Shao, Ziyou Cui, Chunzheng Yang, Zhenping Zhu, Dongsheng Xiong   +7 more
doaj   +1 more source

The molecular mechanism of xanthohumol‐induced apoptosis in MCF‐7 and MCF‐7/ADR cells

The FASEB Journal, 2010
Xanthohumol, the principal prenylated chalcone that only found in the hop plant, Humulus lupulus L., has been shown to possess a variety of pharmacological activities.
Youra Kang, Min‐A Park, Keon‐Wook Kang, Jung‐Ae Kim   +3 more
openaire   +1 more source

Pomegranate seed extract enhances the inhibitory effect of adipose- derived mesenchymal stem cells on breast cancer cell line in co-culture conditions

Research in Pharmaceutical Sciences, 2022
Background and purpose: Pomegranate seed extract (PSE) possesses anticancer activities and healing effects. Adipose-derived stem cells (ADSCs) are being considered a new candidate for cancer treatment.
Nahid Moradi-Gharibvand, Mohsen Setayeshmehr, Mohammad Kazemi, Azadeh Safaee, Laya Sadat Khorsandi, Darioush Bijan Nejad, Seyed Javad Hasheminia, Batool Hashemibeni   +7 more
doaj   +1 more source

Coenzyme Q Depletion Reshapes MCF-7 Cells Metabolism [PDF]

International Journal of Molecular Sciences, 2020
Mitochondrial dysfunction plays a significant role in the metabolic flexibility of cancer cells. This study aimed to investigate the metabolic alterations due to Coenzyme Q depletion in MCF-7 cells. Method: The Coenzyme Q depletion was induced by competitively inhibiting with 4-nitrobenzoate the coq2 enzyme, which catalyzes one of the final reactions ...
Wang W., Liparulo I., Rizzardi N., Bolignano P., Calonghi N., Bergamini C., Fato R.   +6 more
openaire   +4 more sources