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Effects of environmental pollutants on MCF-7 cells: A metabolic approach
Toxicology Letters, 2015Several environmental pollutants (EPs) have been associated with biological and molecular processes leading to adverse human health effects, including different types of cancer. Nevertheless, the effects exerted on tumor glucose metabolism are unclear. To evaluate the effects on cellular and molecular mechanisms, namely glucose metabolism, MCF-7 cells ...
Norberto, Sónia +3 more
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Nicotine increases cancer stem cell population in MCF-7 cells
Biochemical and Biophysical Research Communications, 2010Epidemiological studies have suggested that cigarette smoking is related to increased breast cancer risk. Nicotine is most likely related to the risk in cigarette smoking. However, the mechanisms by which nicotine promotes cancer development are not fully understood.
Naoya, Hirata +2 more
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Bulk protein secretion induced by estradiol in MCF-7 cells
European Journal of Cancer and Clinical Oncology, 1985info:eu-repo/semantics ...
Olea, Nicolás +3 more
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LKB1 expression is inhibited by estradiol-17β in MCF-7 cells
The Journal of Steroid Biochemistry and Molecular Biology, 2011The liver kinase B1 (LKB1) is encoded by the STK11 gene and acts as a tumour suppressor and a regulator of energy homeostasis. LKB1 expression is reduced in primary breast tumours compared to normal breast epithelium. Although its expression in primary tumours does not appear to correlate with estrogen receptor (ER) status, it is differentially ...
Kristy A, Brown +7 more
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Transactivation of TauT by p53 in MCF-7 Cells
2003The p53 tumor suppressor gene functions as a cell cycle checkpoint, blocking cell division in the G1 phase to allow repair of damaged DNA or even triggering apoptosis in cells that have defective genomes 1. Numerous stimuli trigger increases in the level of p53, including DNA-damaging drugs, ionizing radiation, ultraviolet light, and hypoxia 2–5. MCF-7,
Xiaobin Han +2 more
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Elevation of cysteine consumption in tamoxifen-resistant MCF-7 cells
Biochemical Pharmacology, 2013Tamoxifen (TAM) resistance is a main cause of therapeutic failure in breast cancers. Although methionine dependency is a phenotypic characteristic of tumor cells, the role of sulfur amino acid metabolism in chemotherapy resistance remains to be elucidated.
Chang Seon, Ryu +6 more
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A study of induced genotoxicity in MCF-7 cells.
Cytobios, 1996Following upon earlier work the response of MCF-7 breast cancer cells to mitomycin C, a known genotoxicant, was examined. This previous research has yielded a baseline of chromosome aberrations in human peripheral blood lymphocytes from which comparisons can now be made.
H F, Mark +3 more
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