Results 91 to 100 of about 11,749,169 (183)
Human GINS, a conserved DNA replication factor and candidate cancer marker
, 2011 The GINS complex (a heterotetramer of Sld5, Psf1, Psf2 and Psf3) is a highly conserved DNA replication factor required for the initiation and elongation of DNA replication. GINS is believed to associate with Cdc45 and MCM proteins on replicating DNA. The
core +1 more source
Sequential ATP Hydrolysis by Cdc6 and ORC Directs Loading of the Mcm2-7 Helicase [PDF]
Molecular Cell, 2006 Loading of the Mcm2-7 DNA replicative helicase onto origin-proximal DNA is a critical and tightly regulated event during the initiation of eukaryotic DNA replication. The resulting protein-DNA assembly is called the prereplicative complex (pre-RC), and its formation requires the origin recognition complex (ORC), Cdc6, Cdt1, and ATP.
Randell, John C.W. +3 more
openaire +2 more sources
, 2014 (A) Schematic of RIP-origin fragments inserted at ChrIV_567 kb In MC2Ao strains. YJL8398 (RIP317-ARS317, orange) is described in Figure 4B. YJL8541 (RIP317-ars317; white) has ACSs of both ARS317 and the nearby cryptic origin disrupted using the mutations
Christopher D. Richardson (208217) +1 more
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The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, Volume 600, Issue 9, Page 1265-1287, May 2026.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Cell Reports, 2015 Mcm2-7 helicase is loaded onto double-stranded origin DNA as an inactive double hexamer (DH) in G1 phase. The mechanisms of Mcm2-7 remodeling that trigger helicase activation in S phase remain unknown.
Yun Quan +8 more
doaj +1 more source
Advanced Science, Volume 13, Issue 26, 8 May 2026.Single‐cell RNA analyses of paired lesions from CD30+ mycosis fungoides patients demonstrate that brentuximab vedotin (BV) induces immunogenic cell death in both CD30+ and CD30− malignant T cells. BV also targets regulatory T cells and remodels tumor microenvironment, while resistance is driven by impaired IFN responses, drug efflux, and BCL2 ...
Yi Jiang +8 more
wiley +1 more source
The Mcm2-7 complex is the eukaryotic replicative helicase. [PDF]
, 2009 Replicative helicases are essential enzymes in DNA replication that separate duplex DNA into single strands to be used as templates by polymerases. The identity of these helicases in prokaryotes and viruses has been known for some time, but there is ...
Bochman, Matthew L.
core
Terminator prevents displacement of Mcm2-7 ().
, 2019 G1-arrested SIR2 and sir2 strains with and without a CYC1 transcriptional terminator (red line marked with T) (strains 16855, 16895, 16905 and 16920 from left to right with 64, 85, 170 and 81 rDNA copies, respectively), inserted between the start of c ...
Tonibelle Gatbonton-Schwager (5707766) +7 more
core +1 more source
Interdisciplinary Medicine, Volume 4, Issue 3, May 2026.SUMOylation, a dynamic post‐translational modification, acts as a master regulator at the heart of tumor malignancy. Our work delineates how the SUMOylation cycle—mediated by E1/E2/E3 enzymes and reversed by SENPs—orchestrates multiple hallmarks of cancer. The central pathway converges on three critical pathological axes: 1.
Yimao Wu +6 more
wiley +1 more source
Phosphorylation of MCM3 on Ser-112 regulates its incorporation into the MCM2–7 complex [PDF]
Proceedings of the National Academy of Sciences, 2008 During late M and early G 1 , MCM2–7 assembles and is loaded onto chromatin in the final step of prereplicative complex (pre-RC) formation. However, the regulation of MCM assembly remains poorly understood. Cyclin-dependent kinase (CDK)-dependent phosphorylation contributes to DNA replication by initially activating
Douglas I, Lin +2 more
openaire +2 more sources