Results 91 to 100 of about 7,568,861 (163)

Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells

FEBS Open Bio, Volume 16, Issue 6, Page 1181-1196, June 2026.
UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca, Anna Tricarico, Martina Furfaro, Priyam Ghosh, Ennio Prosperi, Lucia Anna Stivala, Ornella Cazzalini   +6 more
wiley   +1 more source

A conserved MCM single-stranded DNA binding element is essential for replication initiation

eLife, 2014
The ring-shaped MCM helicase is essential to all phases of DNA replication. The complex loads at replication origins as an inactive double-hexamer encircling duplex DNA.
Clifford A Froelich, Sukhyun Kang, Leslie B Epling, Stephen P Bell, Eric J Enemark   +4 more
doaj   +1 more source

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, Volume 13, Issue 35, 24 June 2026.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

DMAP1 Deficiency Suppresses Lung Cancer Progression by Destabilizing Replication Fork and Activating IFN Signaling‐Mediated Anti‐tumor Immunity

Advanced Science, Volume 13, Issue 33, 15 June 2026.
Lung cancer remains the leading cause of cancer‐related death. We investigated the role of the epigenetic regulator DMAP1 in NSCLC and found that its loss induces replication stress and DNA damage. This in turn activates type I IFN signaling via the cGAS–STING pathway and transcriptional ISG de‐repression, enhancing anti‐tumor immune responses ...
Kan Huang, Xi Dai, Shuaihu Li, Yingxue Chen, Yaxin Yu, Lin Wang, Kun Liu, Shuhan Lyu, Chongyang Li, Yihua Sun, Fei Li   +10 more
wiley   +1 more source

Terminator prevents displacement of Mcm2-7 ().

, 2019
G1-arrested SIR2 and sir2 strains with and without a CYC1 transcriptional terminator (red line marked with T) (strains 16855, 16895, 16905 and 16920 from left to right with 64, 85, 170 and 81 rDNA copies, respectively), inserted between the start of c ...
Tonibelle Gatbonton-Schwager (5707766), Uyen Lao (422297), David M. MacAlpine (242300), Antonio Bedalov (15251), Rafael Soriano (6694142), Erin Taylor (3741670), Eric J. Foss (206758), Adam H. Thiesen (6694139)   +7 more
core   +1 more source

Concerted Loading of Mcm2–7 Double Hexamers around DNA during DNA Replication Origin Licensing [PDF]

, 2009
SummaryThe licensing of eukaryotic DNA replication origins, which ensures once-per-cell-cycle replication, involves the loading of six related minichromosome maintenance proteins (Mcm2–7) into prereplicative complexes (pre-RCs).
Remus, Dirk, Morris, Edward P., Diffley, John F.X., Beuron, Fabienne, Griffith, Jack D., Tolun, Gökhan   +5 more
core   +1 more source

Deregulation of Cdc6 and Mcm2-7 allows Mcm2-7 to re-associate with origins that do not preferentially re-initiate.

, 2014
(A) Schematic of RIP-origin fragments inserted at ChrIV_567 kb In MC2Ao strains. YJL8398 (RIP317-ARS317, orange) is described in Figure 4B. YJL8541 (RIP317-ars317; white) has ACSs of both ARS317 and the nearby cryptic origin disrupted using the mutations
Christopher D. Richardson (208217), Joachim J. Li (105121)   +1 more
core   +1 more source

Mutation of the zebrafish nucleoporin elys sensitizes tissue progenitors to replication stress.

PLoS Genetics, 2008
The recessive lethal mutation flotte lotte (flo) disrupts development of the zebrafish digestive system and other tissues. We show that flo encodes the ortholog of Mel-28/Elys, a highly conserved gene that has been shown to be required for nuclear ...
Gangarao Davuluri, Weilong Gong, Shamila Yusuff, Kristin Lorent, Manimegalai Muthumani, Amy C Dolan, Michael Pack   +6 more
doaj   +1 more source

MCM family in HCC: MCM6 indicates adverse tumor features and poor outcomes and promotes S/G2 cell cycle progression

BMC Cancer, 2018
Background Minichromosome Maintenance family (MCMs), as replication licensing factors, is involved in the pathogenesis of tumors. Here, we investigated the expression of MCMs and their values in hepatocellular carcinoma (HCC).
Zhikun Liu, Jie Li, Jun Chen, Qiaonan Shan, Haojiang Dai, Haiyang Xie, Lin Zhou, Xiao Xu, Shusen Zheng   +8 more
doaj   +1 more source

The Mcm2-7 complex is the eukaryotic replicative helicase. [PDF]

, 2009
Replicative helicases are essential enzymes in DNA replication that separate duplex DNA into single strands to be used as templates by polymerases. The identity of these helicases in prokaryotes and viruses has been known for some time, but there is ...
Bochman, Matthew L.
core