Results 101 to 110 of about 11,749,169 (183)
A conserved MCM single-stranded DNA binding element is essential for replication initiation
eLife, 2014 The ring-shaped MCM helicase is essential to all phases of DNA replication. The complex loads at replication origins as an inactive double-hexamer encircling duplex DNA.
Clifford A Froelich +4 more
doaj +1 more source
Advanced Science, Volume 13, Issue 20, 9 April 2026.This study reports that SBNO1 protein is upregulated in several cancer entities. SBNO1 protein interacts with the basal transcription factor TFIID via TAF4, enabling its recruitment to transcription start sites and the modulation of target gene expression.
Sarah Fritzsche +21 more
wiley +1 more source
The Roles of the Mcm2-7 Tails in Replication Initiation
, 2022 DNA replication is complex biological reaction that spans two stages of the eukaryotic cell cycle. In G1 phase, preparation for replication begins when two copies of the replicative helicase, the Mcm2-7 complex, are loaded onto DNA.
Gangaramani, Paritosh
core
Cancer Medicine, Volume 15, Issue 4, April 2026.ABSTRACT Lung adenocarcinoma (LUAD) is a predominant form of lung cancer with poor prognosis due to early diagnosis challenges and treatment resistance. Thymidylate synthetase (TYMS), a key enzyme in DNA synthesis, has been associated with poor prognosis in multiple cancers, yet its multi‐omics characteristics in LUAD remain systematically ...
Hansen Shi +7 more
wiley +1 more source
SIR2 deletion repositions Mcm2-7.
, 2019 A. MNase-seq analysis. WT (16535) and sir2 (16668) cells were arrested in G1 or G2 and processed as in Fig 2. B. Mcm2-MNase ChEC-seq analysis. G1-arrested, WT (WT) (16747) and sir2 (16769) mutant cells, whose endogenous copy of MCM2 was tagged with MNase,
Tonibelle Gatbonton-Schwager (5707766) +7 more
core +1 more source
A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replication [PDF]
, 2009 During pre-replication complex (pre-RC) formation, origin recognition complex (ORC), Cdc6, and Cdt1 cooperatively load the 6-subunit mini chromosome maintenance (MCM2-7) complex onto DNA.
Li, H +28 more
core +1 more source
A Novel Dysferlin‐Binding Kinase CK2α Promotes Plasma Membrane Repair in Dysferlinopathy
The FASEB Journal, Volume 40, Issue 6, 31 March 2026.When the cell membrane is injured, extracellular calcium enters the cell, triggering the accumulation of dysferlin at the lesion site. In the presence of dysferlin, CK2 is efficiently recruited to the damaged membrane and maintains its kinase activity through interaction with dysferlin.
Naoko Nakamura +27 more
wiley +1 more source
Mutation of the zebrafish nucleoporin elys sensitizes tissue progenitors to replication stress.
PLoS Genetics, 2008 The recessive lethal mutation flotte lotte (flo) disrupts development of the zebrafish digestive system and other tissues. We show that flo encodes the ortholog of Mel-28/Elys, a highly conserved gene that has been shown to be required for nuclear ...
Gangarao Davuluri +6 more
doaj +1 more source
BMC Cancer, 2018 Background Minichromosome Maintenance family (MCMs), as replication licensing factors, is involved in the pathogenesis of tumors. Here, we investigated the expression of MCMs and their values in hepatocellular carcinoma (HCC).
Zhikun Liu +8 more
doaj +1 more source
Ancient diversification of eukaryotic MCM DNA replication proteins
BMC Evolutionary Biology, 2009 Background Yeast and animal cells require six mini-chromosome maintenance proteins (Mcm2-7) for pre-replication complex formation, DNA replication initiation and DNA synthesis. These six individual MCM proteins form distinct heterogeneous subunits within
Aves Stephen J +2 more
doaj +1 more source