Results 101 to 110 of about 7,568,861 (163)

Ancient diversification of eukaryotic MCM DNA replication proteins

BMC Evolutionary Biology, 2009
Background Yeast and animal cells require six mini-chromosome maintenance proteins (Mcm2-7) for pre-replication complex formation, DNA replication initiation and DNA synthesis. These six individual MCM proteins form distinct heterogeneous subunits within
Aves Stephen J, Richards Thomas A, Liu Yuan   +2 more
doaj   +1 more source

A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replication [PDF]

, 2009
During pre-replication complex (pre-RC) formation, origin recognition complex (ORC), Cdc6, and Cdt1 cooperatively load the 6-subunit mini chromosome maintenance (MCM2-7) complex onto DNA.
Li, H, Sun, J. C., Zech, J, Clarke, P., Li, H. L., Sunc, Jingchuan, Stillman, B., Stillman, B, Zech, Juergen, Lurz, Rudi, Speck, C., Li, Huilin, Uhle, S., Uhle, Stefan, Evrin, Cecile, Stillman, Bruce, Speck, Christian, Speck, C, Lurz, R., Clarke, Pippa, Sun, J, Lurz, R, Zech, J., Evrin, C., Clarke, P, Sunc, J., Uhle, S, Evrin, C, Li, H.   +28 more
core   +1 more source

SIR2 deletion repositions Mcm2-7.

, 2019
A. MNase-seq analysis. WT (16535) and sir2 (16668) cells were arrested in G1 or G2 and processed as in Fig 2. B. Mcm2-MNase ChEC-seq analysis. G1-arrested, WT (WT) (16747) and sir2 (16769) mutant cells, whose endogenous copy of MCM2 was tagged with MNase,
Tonibelle Gatbonton-Schwager (5707766), Uyen Lao (422297), David M. MacAlpine (242300), Antonio Bedalov (15251), Rafael Soriano (6694142), Erin Taylor (3741670), Eric J. Foss (206758), Adam H. Thiesen (6694139)   +7 more
core   +1 more source

Rethinking origin licensing

eLife, 2017
Human cells that lack a subunit in their origin recognition complex are viable, which suggests the existence of alternative mechanisms to initiate DNA replication.
Stephen P Bell
doaj   +1 more source

Abstracts

Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.
Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

A unique DNA entry gate serves for regulated loading of the eukaryotic replicative helicase MCM2-7 onto DNA [PDF]

, 2014
01.09.14 KB. Embargo period of 6 months before published version can be deposited.The regulated loading of the replicative helicase minichromosome maintenance proteins 2–7 (MCM2–7) onto replication origins is a prerequisite for replication fork ...
Sun, Jingchuan, Herrera, M Carmen, Tognetti, Silvia, Samel, Stefan A, Speck, Christian, Riera, Alberto, Fernandez-Cid, Alejandra, Li, Huilin   +7 more
core   +1 more source

ATPase activity and DNA binding by Mcm2-7_3K499A.

, 2013
(A) The reconstituted Mcm2-7 and Mcm2-73K499A complexes were tested for ATPase activity by incubating with [γ32P]-ATP and measuring the radioactivity of free Pi produced at the time points indicated.
Tina L. Sing (496154), Christopher J. Brandl (496156), Brian H. Shilton (496155), Megan J. Davey (496157), Simon K. W. Lam (496153), Xiaoli Ma (88826)   +5 more
core   +1 more source

CRL4DCAF12 regulation of MCMBP ensures optimal licensing of DNA replication

Nature Communications
The minichromosome maintenance (MCM2-7) protein complexes are central drivers of genome duplication. Distinct protein pools, parental and nascent MCMs, and their precise equilibrium are essential to sustain error-free DNA replication.
Anoop Kumar Yadav, Alikhan Abdirov, Katarina Ondruskova, Simran Negi, Kristina Jamrichova, Karolina Kolarova, Nikol Dibus, Jana Krejci, Hana Polasek-Sedlackova, Lukas Cermak   +9 more
doaj   +1 more source

Bioinformatic Analysis of the Expression and Clinical Significance of the DNA Replication Regulator MCM Complex in Bladder Cancer

International Journal of General Medicine, 2022
Ru Chen,1,2,* Bing Hu,1,* Ming Jiang,1,* Wen Deng,1 Ping Zheng,3 Bin Fu1,4 1Department of Urology, the First Affiliated Hospital of Nanchang University, Nanchang City, Jiangxi Province, People’s Republic of China; 2Department of Urology, The ...
Chen R, Hu B, Jiang M, Deng W, Zheng P, Fu B   +5 more
doaj  

Regulation of replication origin licensing by ORC phosphorylation reveals a two-step mechanism for Mcm2-7 ring closing. [PDF]

Proc Natl Acad Sci U S A, 2023
Amasino AL, Gupta S, Friedman LJ, Gelles J, Bell SP.   +4 more
europepmc   +1 more source