Results 121 to 130 of about 11,749,169 (183)

Chronic replication stress-mediated genomic instability disrupts placenta development in mice.

PLoS Genetics
Abnormal placentation drives many pregnancy-related pathologies and poor fetal outcomes, but the underlying molecular causes are understudied. Here, we show that persistent replication stress due to mutations in the MCM2-7 replicative helicase disrupts ...
Mumingjiang Munisha, Rui Huang, Jordan Khan, John C Schimenti   +3 more
doaj   +1 more source

Poster Sessions

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

Replication licensing regulated by a short linear motif within an intrinsically disordered region of origin recognition complex

Nature Communications
In eukaryotes, the origin recognition complex (ORC) faciliates the assembly of pre-replicative complex (pre-RC) at origin DNA for replication licensing.
Yue Wu, Qiongdan Zhang, Yuhan Lin, Wai Hei Lam, Yuanliang Zhai   +4 more
doaj   +1 more source

Investigating the Mechanism of Activation of the Mcm2-7 Replicative Helicase [PDF]

, 2015
DNA replication initiation is co-ordinated with progression through the cell cycle via a two-step mechanism. The first step, termed origin licensing, involves the assembly of a pre-replicative complex (pre-RC) at origins of replication, in which the Mcm2-
Deegan, TD
core  

RS-induced MCM2-7 downregulation precedes loss of DNA replication.

, 2016
(A) Cell cycle profiles of WT primary MEFs under chronic RS. Plots are of DNA content as assessed by flow cytometry. The percentages of cells in each stage of the cell cycle are shown. Three technical repeats were performed.
John C. Schimenti (124491), Gongshi Bai (845681), Marcus B. Smolka (374811)   +2 more
core   +1 more source

Replikatiivse helikaasikompleksi MCM2-7 subühikute taseme reguleerimine oksüdatiivse stressi sensorvalk KEAP1 poolt [PDF]

, 2016
Replikatiivne helikaasikompleks MCM2-7 omab väga olulist rolli DNA replikatsiooni initsiatsioonis ja selle regulatsioonis. Oksüdatiivse stressi sensorvalk KEAP1 interakteerub helikaasi subühikutega MCM3 ja MCM7, kuid selle interaktsiooni roll rakus ei ...
Raja, Gerda
core  

RS responsive miRNAs repress MCM2-7 expression.

, 2016
(A) RS induced miRNA upregulation depends on Trp53. miRNA levels were quantified by qRT-PCR and normalized to U6 small nuclear RNA (RNU6). The HU treatment was 200μM for 72h. Error bar = SEM. CTL = control.
John C. Schimenti (124491), Gongshi Bai (845681), Marcus B. Smolka (374811)   +2 more
core   +1 more source

Abstracts From PVRI 2026 Dublin

Pulmonary Circulation, Volume 16, Issue 2, June 2026.
wiley   +1 more source

Chromatin’s Influence on Pre-Replication Complex Assembly and Function

Biology
In all eukaryotes, the initiation of DNA replication requires a stepwise assembly of factors onto the origins of DNA replication. This is pioneered by the Origin Recognition Complex, which recruits Cdc6.
Hina Ahmad, Neha Chetlangia, Supriya G. Prasanth   +2 more
doaj   +1 more source

REGULATION OF GENOME STABILITY VIA MCM2-7 ATPASE ACTIVE SITES IN SACCHAROMYCES CEREVISIAE [PDF]

, 2014
Genome stability is vital to the survival and health of eukaryotic organisms. Consequently, many complex mechanisms coordinate with each other in an intricate fashion to ensure that genomes are preserved during duplication and its subsequent propagation.
Vijayraghavan, Sriram
core