A Meier-Gorlin syndrome mutation impairs the loading of the MCM2-7 complex during DNA replication initiation. [PDF]
Proc Natl Acad Sci U S ALiu Y +11 more
europepmc +1 more source
Specific origin selection and excess functional MCM2-7 loading in ORC-deficient cells. [PDF]
Nucleic Acids ResShibata Y +5 more
europepmc +1 more source
Sir2 suppresses transcription-mediated displacement of Mcm2-7 replicative helicases at the ribosomal DNA repeats. [PDF]
PLoS Genet, 2019 Foss EJ +7 more
europepmc +1 more source
dRnh1-GFP and Drug Discovery: A Toolkit for Better Understanding the Mcm2-7 Replicative Helicase
The faithful replication of the DNA code is essential for the propagation of living cells. At the head of this replication process is the DNA helicase Mcm2-7, which serves to unwind DNA’s double-helix structure and provide access for the DNA replication ...
Sanders, Jordan
core
Targeting CDC7 sensitizes resistance melanoma cells to BRAFV600E-specific inhibitor by blocking the CDC7/MCM2-7 pathway. [PDF]
Sci Rep, 2019 Gad SA +9 more
europepmc +1 more source
Pre-initiation complex assembly functions as a molecular switch that splits the Mcm2-7 double hexamer. [PDF]
EMBO Rep, 2017 Miyazawa-Onami M, Araki H, Tanaka S.
europepmc +1 more source
Potent DNA strand annealing activity associated with mouse Mcm2∼7 heterohexameric complex. [PDF]
Nucleic Acids Res, 2017 You Z, Masai H.
europepmc +1 more source
Cryo-EM structure of Mcm2-7 double hexamer on DNA suggests a lagging-strand DNA extrusion model. [PDF]
Proc Natl Acad Sci U S A, 2017 Noguchi Y +7 more
europepmc +1 more source
Molecular architecture of the recombinant human MCM2-7 helicase in complex with nucleotides and DNA. [PDF]
Cell Cycle, 2016 Boskovic J +7 more
europepmc +1 more source
The Dbf4-Cdc7 kinase promotes Mcm2-7 ring opening to allow for single-stranded DNA extrusion and helicase assembly. [PDF]
J Biol Chem, 2017 Bruck I, Kaplan DL.
europepmc +1 more source