Results 141 to 150 of about 11,749,169 (183)

Dpb11 protein helps control assembly of the Cdc45·Mcm2-7·GINS replication fork helicase. [PDF]

J Biol Chem, 2015
Dhingra N, Bruck I, Smith S, Ning B, Kaplan DL.   +4 more
europepmc   +1 more source

CDK4/6i reverse PARPi resistance by targeting the E2F1- MCM2/5 pathway. [PDF]

NPJ Precis Oncol
Feng Y, Fu M, Zheng B, Lou F, Huang X, Xie X, Tan W, Chen Q, Zhang W, Hong Y, Rong K, Shi H, Hu T, Xiao L.   +13 more
europepmc   +1 more source

Association of baseline tumor-infiltrating lymphocytes and cell-cycle regulation markers on prognosis and mortality in patients with advanced breast cancer according to tumor characteristics and treatment type: an observational study. [PDF]

Breast Cancer Res Treat
Vuoti S, Saari M, Lahti J, Narasimha K, Reinikainen K.   +4 more
europepmc   +1 more source

Archaeal and eukaryotic MCM rings sequentially melt DNA for replication initiation. [PDF]

Nat Commun
Rasouli S, Myasnikov A, Enemark EJ.
europepmc   +1 more source

Prognostic stratification of chordoid meningiomas: the role of chromosome 1p/22q Loss. [PDF]

Acta Neuropathol Commun
Paterra R, Zago M, Agistri F, Hernandez Gamero G, Mafficini A, Pedron S, Berlendis A, Nozzoli F, Di Meco F, Barresi V.   +9 more
europepmc   +1 more source

Manic switching from depression is affected by adult hippocampal neurogenesis. [PDF]

Anim Cells Syst (Seoul)
Song J, Kim W, Park Y, Lee JM, Kim JH, Park DH, Lee HJ, Shin KS, Kim HJ, Geum D.   +9 more
europepmc   +1 more source

Investigating the Mechanism of Activation of the Mcm2-7 Replicative Helicase

openaire   +1 more source

Structure of the MCM2-7 Double Hexamer and Its Implications for the Mechanistic Functions of the Mcm2-7 Complex.

Advances in Experimental Medicine and Biology, 2017
The eukaryotic minichromosome maintenance 2-7 complex is the core of the inactive MCM replication licensing complex and the catalytic core of the Cdc45-MCM-GINS replicative helicase. The years of effort to determine the structure of parts or the whole of the heterohexameric complex by X-ray crystallography and conventional cryo-EM produced limited ...
Y. Zhai, B. Tye
semanticscholar   +6 more sources

Is the MCM2–7 complex the eukaryotic DNA replication fork helicase?

Current Opinion in Genetics and Development, 2001
The MCM2-7 complex is essential for both the initiation and elongation phases of eukaryotic chromosome replication. There is some evidence that MCM2-7 proteins may act as a DNA helicase; at the same time, a variety of other DNA helicases have also been implicated in the replication of eukaryotic chromosomes.
Karim Labib, John F X Diffley
exaly   +5 more sources

Concerted Loading of Mcm2–7 Double Hexamers around DNA during DNA Replication Origin Licensing

Cell, 2009
SummaryThe licensing of eukaryotic DNA replication origins, which ensures once-per-cell-cycle replication, involves the loading of six related minichromosome maintenance proteins (Mcm2–7) into prereplicative complexes (pre-RCs).
Dirk Remus, Fabienne Beuron, Gokhan Tolun   +2 more
exaly   +3 more sources