Results 161 to 170 of about 11,749,169 (183)

Quinolone-inspired MCM2-7 helicase inhibitors: Computational design, dynamic stability, and preclinical promise for targeted anticancer therapy.

Journal of Molecular Graphics and Modelling
The Mini-Chromosome Maintenance (MCM) 2-7 helicase complex is a pivotal component of the eukaryotic DNA replication machinery and an emerging therapeutic target in oncology due to its role in replication licensing and genomic stability.
S. Elabed, Wael M. Elshemey, Ammar Y. Mohamed, M. Shafaa   +3 more
semanticscholar   +1 more source

Assembly of the Cdc45-MCM2-7-GINS Complex, the Replication Helicase

2016
In eukaryotes, a crucial step during the initiation of DNA replication is the timely formation and activation of the replicative DNA helicase composed of Cdc45, MCM2-7 and GINS (CMG). The dynamic and spatio-temporal events leading to the ordered and stepwise assembly of the CMG helicase are tightly regulated.
Helmut Pospiech, Anna Szambowska
openaire   +1 more source

WASHC1 interacts with MCM2-7 complex to promote cell survival under replication stress

Molecular Biology Reports, 2022
Yu Hong, He Sun, Xian Hong, Cai-Ping Yang, D. Billadeau, Tao Wang, Zhi-Hui Deng   +6 more
semanticscholar   +1 more source

Multi-Omics Analysis of MCM2 as a Promising Biomarker in Pan-Cancer

Frontiers in Cell and Developmental Biology, 2022
Hua Lan, Dongqing Huang, Chu Liu
exaly  

Cryo-EM structure of DNA-unbound human MCM2–7 complex reveals new disease-relevant regulation

bioRxiv
Yusong Liu, Mengquan Yang, Ping Lu, Haishan Gao, Maozhou He, Yitao Wang, Ao Qi, Ting Cao, Qiuqin Zhang, Shutao Qi, Yigong Shi, Hongtao Yu   +11 more
semanticscholar   +1 more source

Open-ringed structure of the Cdt1–Mcm2–7 complex as a precursor of the MCM double hexamer

Nature Structural &Molecular Biology, 2017
Y. Zhai, E. Cheng, Hao Wu, Ningning Li, P. Y. Yung, N. Gao, B. Tye   +6 more
semanticscholar   +1 more source

Expression and biochemical studies of the human MCM2-7 helicase

2015
1987
openaire   +1 more source

Abstract 1167: MCM2-7 complex is a novel druggable target for neuroendocrine prostate cancer

Experimental and Molecular Therapeutics, 2021
Tanya Stoyanova
semanticscholar   +1 more source

The Mcm2-Ctf4-Polα Axis Facilitates Parental Histone H3-H4 Transfer to Lagging Strands

Molecular Cell, 2018
Haiyun Gan, Albert Serra-Cardona, Xu Hua   +2 more
exaly  

A key role for Ctf4 in coupling the MCM2‐7 helicase to DNA polymerase α within the eukaryotic replisome

EMBO Journal, 2009
Agnieszka Gambus, Dimitris Polychronopoulos, Magdalena Foltman   +2 more
exaly