Results 1 to 10 of about 1,425,864 (268)

Replication origin–flanking roadblocks reveal origin-licensing dynamics and altered sequence dependence [PDF]

Journal of Biological Chemistry, 2017
In eukaryotes, DNA replication initiates from multiple origins of replication for timely genome duplication. These sites are selected by origin licensing, during which the core enzyme of the eukaryotic DNA replicative helicase, the Mcm2-7 (minichromosome maintenance) complex, is loaded at each origin.
Ishara F Azmi, Stephen P. Bell, Sukhyun Kang   +2 more
exaly   +5 more sources

Human RIF1 and protein phosphatase 1 stimulate DNA replication origin licensing but suppress origin activation [PDF]

EMBO Reports, 2017
Angus Lamond, Simon Boulton, Anne D Donaldson   +2 more
exaly   +2 more sources

Mechanism and timing of Mcm2–7 ring closure during DNA replication origin licensing [PDF]

Nature Structural and Molecular Biology, 2017
Jeff Gelles, Stephen P. Bell, Ivan R Correa   +2 more
exaly   +2 more sources

Correction: Rapid DNA replication origin licensing protects stem cell pluripotency

eLife, 2019
Jacob Peter Matson, Raluca Dumitru, Philip Coryell, Ryan M Baxley, Weili Chen, Kirk Twaroski, Beau R Webber, Jakub Tolar, Anja-Katrin Bielinsky, Jeremy E Purvis, Jeanette Gowen Cook   +10 more
doaj   +2 more sources

The remarkable gymnastics of ORC

eLife, 2022
As a cell prepares to divide, a molecular actor known as the Origin Recognition Complex makes intricate ATP-driven movements to recruit proteins required to duplicate DNA.
Bruce Stillman
doaj   +1 more source

Neural network and kinetic modelling of human genome replication reveal replication origin locations and strengths.

PLoS Computational Biology, 2023
In human and other metazoans, the determinants of replication origin location and strength are still elusive. Origins are licensed in G1 phase and fired in S phase of the cell cycle, respectively.
Jean-Michel Arbona, Hadi Kabalane, Jeremy Barbier, Arach Goldar, Olivier Hyrien, Benjamin Audit   +5 more
doaj   +1 more source

Single-Molecule Studies of Origin Licensing Reveal Mechanisms Ensuring Bidirectional Helicase Loading [PDF]

Cell, 2015
Jeff Gelles, Stephen P. Bell, Larry J Friedman   +2 more
exaly   +2 more sources

Ιn vivo imaging of DNA-bound minichromosome maintenance complex in embryonic mouse cortex

STAR Protocols, 2021
Summary: The recruitment of the minichromosome maintenance complex (MCM) on DNA replication origins is a critical process for faithful genome duplication termed licensing.
Maria Mougkogianni, Argyro Kalogeropoulou, Nickolaos Nikiforos Giakoumakis, Zoi Lygerou, Stavros Taraviras   +4 more
doaj   +1 more source

A helicase-tethered ORC flip enables bidirectional helicase loading

eLife, 2021
Replication origins are licensed by loading two Mcm2-7 helicases around DNA in a head-to-head conformation poised to initiate bidirectional replication. This process requires origin–recognition complex (ORC), Cdc6, and Cdt1.
Shalini Gupta, Larry J Friedman, Jeff Gelles, Stephen P Bell   +3 more
doaj   +1 more source

Origin Licensing Requires ATP Binding and Hydrolysis by the MCM Replicative Helicase

Molecular Cell, 2014
John Diffley, Gideon Coster, Jordi Frigola   +2 more
exaly   +2 more sources