Results 31 to 40 of about 1,425,864 (268)
Sir2 mitigates an intrinsic imbalance in origin licensing efficiency between early- and late-replicating euchromatin [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2020 Michael Weinreich +2 more
exaly +2 more sources
Yeast ORC sumoylation status fine-tunes origin licensing. [PDF]
Genes Dev, 2022 Sumoylation is emerging as a posttranslation modification important for regulating chromosome duplication and stability. The origin recognition complex (ORC) that directs DNA replication initiation by loading the MCM replicative helicase onto origins is sumoylated in both yeast and human cells.
Regan-Mochrie G +7 more
europepmc +5 more sources
The consequences of differential origin licensing dynamics in distinct chromatin environments. [PDF]
Nucleic Acids Res, 2022 Abstract Eukaryotic chromosomes contain regions of varying accessibility, yet DNA replication factors must access all regions. The first replication step is loading MCM complexes to license replication origins during the G1 cell cycle phase.
Mei L +4 more
europepmc +5 more sources
An Orc6 tether mediates ORC binding-site switching during replication origin licensing [PDF]
Proceedings of the National Academy of Sciences of the United States of AmericaJeff Gelles +2 more
exaly +2 more sources
DNA replication origins retain mobile licensing proteins [PDF]
Nature Communications, 2021 AbstractDNA replication in eukaryotes initiates at many origins distributed across each chromosome. Origins are bound by the origin recognition complex (ORC), which, with Cdc6 and Cdt1, recruits and loads the Mcm2-7 (MCM) helicase as an inactive double hexamer during G1 phase. The replisome assembles at the activated helicase in S phase.
Humberto Sánchez +7 more
openaire +6 more sources
The Origin of the “MIT License” [PDF]
IEEE Annals of the History of Computing, 2020 Discusses the origin and history of the “MIT License.” This license has become a popular way of releasing copyrighted computer programs for others to use without requiring signatures or a license fee. The quoted words refer to a group of software licenses that have common ancestry and guiding principles but varying wordings.
openaire +1 more source
License to Replicate: Mechanisms of Licensing Eukaryotic Origins for DNA Replication. [PDF]
BioessaysABSTRACT Accurate and timely genome replication is a universal feature of living organisms and a prerequisite for cell proliferation. In eukaryotes, genomic DNA replication initiates in two steps, origin licensing and origin firing, reflecting the loading and activation of the MCM replicative helicase motor on origin DNA.
Frisbie V, Bleichert F.
europepmc +3 more sources
Defects in the origin licensing checkpoint stresses cells exiting G0. [PDF]
J Cell Biol, 2019 The full licensing of replication origins in late G1 is normally enforced by the licensing checkpoint. In this issue, Matson et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201902143) show that this checkpoint is inoperative in cells exiting from G0, resulting in incomplete origin licensing and consequent replicative stress.
Blow JJ.
europepmc +6 more sources
Quantitative profiling of adaptation to cyclin E overproduction
Life Science Alliance, 2022 Detailed analysis of individual human cells responding then adapting to the stress of chronic cyclin E overproduction, which inhibits DNA replication origin licensing by inducing premature S phase. Cyclin E/CDK2 drives cell cycle progression from G1 to S
Juanita C Limas +10 more
doaj +1 more source
ATPase-dependent quality control of DNA replication origin licensing. [PDF]
Nature, 2013 The regulated loading of the Mcm2-7 DNA helicase (comprising six related subunits, Mcm2 to Mcm7) into pre-replicative complexes at multiple replication origins ensures precise once per cell cycle replication in eukaryotic cells. The origin recognition complex (ORC), Cdc6 and Cdt1 load Mcm2-7 into a double hexamer bound around duplex DNA in an ATP ...
Frigola J +3 more
europepmc +4 more sources