Results 21 to 30 of about 1,425,864 (268)

APC/C – the master controller of origin licensing? [PDF]

Cell Division, 2007
DNA replication must be tightly controlled to prevent initiation of a second round of replication until mitosis is complete. So far, components of the pre-replicative complex (Cdt1, Cdc6 and geminin) were considered key players in this regulation.
Dutta Anindya, Machida Yuichi J, Sivaprasad Umasundari   +2 more
doaj   +3 more sources

MCM2-7 loading-dependent ORC release ensures genome-wide origin licensing [PDF]

Nature Communications
Origin recognition complex (ORC)-dependent loading of the replicative helicase MCM2-7 onto replication origins in G1-phase forms the basis of replication fork establishment in S-phase.
L. Maximilian Reuter, Sanjay P. Khadayate, Audrey Mossler, Korbinian Liebl, Sarah V. Faull, Mohammad M. Karimi, Christian Speck   +6 more
doaj   +2 more sources

The Origin Recognition Complex: From Origin Selection to Replication Licensing in Yeast and Humans

Biology, 2023
Understanding human DNA replication through the study of yeast has been an extremely fruitful journey. The minichromosome maintenance (MCM) 2–7 genes that encode the catalytic core of the eukaryotic replisome were initially identified through forward ...
Bik-Kwoon Tye, Yuanliang Zhai
doaj   +4 more sources

Deficiency in origin licensing proteins impairs cilia formation: implications for the aetiology of Meier-Gorlin syndrome. [PDF]

PLoS Genetics, 2013
Mutations in ORC1, ORC4, ORC6, CDT1, and CDC6, which encode proteins required for DNA replication origin licensing, cause Meier-Gorlin syndrome (MGS), a disorder conferring microcephaly, primordial dwarfism, underdeveloped ears, and skeletal ...
Tom Stiff, Meryem Alagoz, Diana Alcantara, Emily Outwin, Han G Brunner, Ernie M H F Bongers, Mark O'Driscoll, Penny A Jeggo   +7 more
doaj   +2 more sources

Unidirectional MCM translocation away from ORC drives origin licensing [PDF]

Nature Communications
The MCM motor of the eukaryotic replicative helicase is loaded as a double hexamer onto DNA by the Origin Recognition Complex (ORC), Cdc6, and Cdt1. ATP binding supports formation of the ORC-Cdc6-Cdt1-MCM (OCCM) helicase-recruitment complex where ORC ...
Agata Butryn, Julia F. Greiwe, Alessandro Costa   +2 more
doaj   +2 more sources

Multiple kinases inhibit origin licensing and helicase activation to ensure reductive cell division during meiosis [PDF]

eLife, 2018
Meiotic cells undergo a single round of DNA replication followed by two rounds of chromosome segregation (the meiotic divisions) to produce haploid gametes.
David V Phizicky, Luke E Berchowitz, Stephen P Bell   +2 more
doaj   +2 more sources

Changing protein–DNA interactions promote ORC binding-site exchange during replication origin licensing [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2023
Jeff Gelles, Stephen P. Bell, Annie Zhang   +2 more
exaly   +2 more sources

Temporal control of human DNA replication licensing by CDK4/6-RB signalling and chemical genetics [PDF]

Nature Communications
Cyclin-dependent kinases (CDKs) coordinate DNA replication and cell division, and play key roles in tissue homeostasis, genome stability and cancer development.
Anastasia Sosenko Piscitello, Ann-Sofie Nilsson, Michael Hawgood, Abid H. Sayyid, Vasilis S. Dionellis, Giovanni Giglio, Bruno Urién, Pratikiran Bajgain, Sotirios G. Ntallis, Jiri Bartek, Thanos D. Halazonetis, Bennie Lemmens   +11 more
doaj   +2 more sources

CDT1 inhibits CMG helicase in early S phase to separate origin licensing from DNA synthesis [PDF]

Molecular Cell, 2023
Joseph T P Yeeles, Nalin Ratnayeke, Mingyu Chung   +2 more
exaly   +2 more sources

Replication licensing regulated by a short linear motif within an intrinsically disordered region of origin recognition complex

Nature Communications
In eukaryotes, the origin recognition complex (ORC) faciliates the assembly of pre-replicative complex (pre-RC) at origin DNA for replication licensing.
Yuanliang Zhai, Wai Hei Lam, Yuhan Lin
exaly   +2 more sources