Results 51 to 60 of about 1,425,864 (268)
HOXD13 Binds DNA Replication Origins To Promote Origin Licensing and Is Inhibited by Geminin [PDF]
Molecular and Cellular Biology, 2009 HOX DNA-binding proteins control patterning during development by regulating processes such as cell aggregation and proliferation. Recently, a possible involvement of HOX proteins in replication origin activity was suggested by results showing that a number of HOX proteins interact with the DNA replication licensing regulator geminin and bind a ...
SALSI, Valentina +5 more
openaire +2 more sources
Ornamental Aquatic Plant Production in Florida
EDIS, 2022 Florida has a unique and diverse aquaculture industry consisting of ornamental fish, food fish, shellfish, alligators, aquatic plants, and more. Although some aquatic plants are produced for food or wetland restoration, most aquatic plant production in
Eric J. Cassiano, Lyn A. Gettys
doaj +3 more sources
Frontiers in Pharmacology, 2022 DNA replication initiation requires the loading of MCM2-7 complexes at the origins of replication during G1. Replication licensing renders chromatin competent for DNA replication and its tight regulation is essential to prevent aberrant DNA replication ...
Nikolaos Karantzelis +10 more
doaj +1 more source
eLife, 2013 In eukaryotes, DNA replication requires the origin recognition complex (ORC), a six-subunit assembly that promotes replisome formation on chromosomal origins.
Franziska Bleichert +5 more
doaj +1 more source
Preventing DNA over-replication: a Cdk perspective
Cell Division, 2008 The cell cycle is tightly controlled to ensure that replication origins fire only once per cycle and that consecutive S-phases are separated by mitosis.
Porter Andrew CG
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Changes in association of the Xenopus origin recognition complex with chromatin on licensing of replication origins [PDF]
Journal of Cell Science, 1999 ABSTRACT During late mitosis and early G1, a series of proteins are assembled onto replication origins that results in them becoming ‘licensed’ for replication in the subsequent S phase. In Xenopus this first involves the assembly onto chromatin of the Xenopus origin recognition complex XORC, and then XCdc6, and finally the RLF-M ...
Rowles, A, Tada, S, Blow, J J
openaire +3 more sources
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
The MCM2-7 Complex: Roles beyond DNA Unwinding
BiologyThe MCM2-7 complex is a hexameric protein complex that serves as a DNA helicase. It unwinds the DNA double helix during DNA replication, thereby providing the single-stranded replication template.
Brooke D. Rankin, Susannah Rankin
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source