The Regulated Loading and Distribution of the Mcm2-7 Helicase During G1 [PDF]
, 2014 DNA replication is the process of synthesizing an exact copy of a genome during S-phase. DNA replication must only occur once and only once in the cell cycle.
Powell, Sara Kathleen
core
dRnh1-GFP and Drug Discovery: A Toolkit for Better Understanding the Mcm2-7 Replicative Helicase
The faithful replication of the DNA code is essential for the propagation of living cells. At the head of this replication process is the DNA helicase Mcm2-7, which serves to unwind DNA’s double-helix structure and provide access for the DNA replication ...
Sanders, Jordan
core
, 2018 Un des acteurs essentiels de la réplication de l’ADN est le complexe MCM2-7. Ce complexe est composé de 6 protéines (MCM2 à MCM7) organisées en hexamères qui sont recrutés aux origines de réplication pendant la phase G1.
Leturcq, Maïté
core
Multiple Cdt1 molecules act at each origin to load replication-competent Mcm2-7 helicases
, 2011 Eukaryotic origins of replication are selected by loading a head-to-head double hexamer of the Mcm2-7 replicative helicase around origin DNA. Cdt1 plays an essential but transient role during this event; however, its mechanism of action is unknown ...
Thomas J Takara, Stephen P Bell
core
Potent DNA strand annealing activity associated with mouse Mcm2∼7 heterohexameric complex. [PDF]
Nucleic Acids Res, 2017 You Z, Masai H.
europepmc +1 more source
The role of the Mcm2 subunit in regulating the activities of the Mcm2-7 helicase
, 2010 The transmission of genetic information from parental to daughter cells requires the faithful duplication of an organism’s genome. Uncontrolled DNA replication can result in proliferative diseases, such as cancer. DNA replication requires a single-stranded DNA template to be produced from duplex DNA.
openaire +1 more source
The Dbf4-Cdc7 kinase promotes Mcm2-7 ring opening to allow for single-stranded DNA extrusion and helicase assembly. [PDF]
J Biol Chem, 2017 Bruck I, Kaplan DL.
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Post-licensing Specification of Eukaryotic Replication Origins by Facilitated Mcm2-7 Sliding along DNA. [PDF]
Mol Cell, 2015 Gros J +5 more
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Multiplexed P21/MCM-2 Detection Predicts Relapse and May Identify Tyrosine Kinase Inhibitor-Resistant Patients in Clear Cell Renal Cell Carcinoma. [PDF]
Cancer Res CommunAbdullah H +10 more
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Archaeal MCM Proteins as an Analog for the Eukaryotic Mcm2-7 Helicase to Reveal Essential Features of Structure and Function. [PDF]
Archaea, 2015 Miller JM, Enemark EJ.
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