Results 131 to 140 of about 7,568,861 (163)

TIMELESS Suppresses the Accumulation of Aberrant CDC45·MCM2-7·GINS Replicative Helicase Complexes on Human Chromatin. [PDF]

J Biol Chem, 2016
Xu X, Wang JT, Li M, Liu Y.
europepmc   +1 more source

An intact Mcm10 coiled-coil interaction surface is important for origin melting, helicase assembly and the recruitment of Pol-α to Mcm2-7. [PDF]

Nucleic Acids Res, 2017
Perez-Arnaiz P, Bruck I, Colbert MK, Kaplan DL.   +3 more
europepmc   +1 more source

Post-licensing Specification of Eukaryotic Replication Origins by Facilitated Mcm2-7 Sliding along DNA. [PDF]

Mol Cell, 2015
Gros J, Kumar C, Lynch G, Yadav T, Whitehouse I, Remus D.   +5 more
europepmc   +1 more source

The Mcm2-7-interacting domain of human mini-chromosome maintenance 10 (Mcm10) protein is important for stable chromatin association and origin firing. [PDF]

J Biol Chem, 2017
Izumi M, Mizuno T, Yanagi KI, Sugimura K, Okumura K, Imamoto N, Abe T, Hanaoka F.   +7 more
europepmc   +1 more source

Suppression of MCM2 reduces cancer stem cells and epithelial-mesenchymal transition-related phenotypes in breast cancer cells. [PDF]

Korean J Clin Oncol
Kim RK.
europepmc   +1 more source

A lethal ORC ATPase mutation is suppressed by alterations in ORC and RNA Pol II transcription components. [PDF]

PLoS One
Martínez-Rodríguez LE, Bell SP.
europepmc   +1 more source

Exploring the multifaceted Dbf4-dependent kinase from temporal, spatial, and substrate repertoire perspectives. [PDF]

Commun Biol
Galanti L, Pfander B.
europepmc   +1 more source

Investigating the Mechanism of Activation of the Mcm2-7 Replicative Helicase

openaire   +1 more source

Changes in MCM2–7 proteins at senescence

Genes and Genetic Systems, 2019
Cellular aging is characterized by the loss of DNA replication capability and is mainly brought about by various changes in chromatin structure. Here, we examined changes in MCM2-7 proteins, which act as a replicative DNA helicase, during aging of human WI38 fibroblasts at the single-cell level.
Yukio Ishimi
exaly   +3 more sources

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Is the MCM2–7 complex the eukaryotic DNA replication fork helicase?

Current Opinion in Genetics and Development, 2001
The MCM2-7 complex is essential for both the initiation and elongation phases of eukaryotic chromosome replication. There is some evidence that MCM2-7 proteins may act as a DNA helicase; at the same time, a variety of other DNA helicases have also been implicated in the replication of eukaryotic chromosomes.
John Diffley, Karim Labib
exaly   +4 more sources