Results 111 to 120 of about 7,568,861 (163)

Geminin inhibits DNA replication licensing by sterically blocking CDT1-MCM2 interactions

Nature Communications
DNA replication is tightly regulated to occur once per cell cycle, with the MCM2-7 helicase loaded onto replication origins only during G1-phase. In higher eukaryotes, geminin negatively regulates this process during S-, G2- and M-phases by binding the ...
Joshua Tomkins, Lucy V. Edwardes, Sarah V. Faull, Matthew Peach, Peter J. Gillespie, Vera Leber, Anna Schmidt, Halil Bounoua, Nicholas Sim, Rosa Camarillo, J. Julian Blow, Alexis R. Barr, Anna Barnard, Christian Speck   +13 more
doaj   +1 more source

Complejo mcm2-7.: Revisión bibliográfica

, 2019
New cells are formed from preexisting cells through an ordered series of events called cell cycle. As the control of this cycle is fundamental for genome integrity, multiple proteins regulate this process.
Tapia-Repetto, Gabriel, Pereira-Prado, Vanesa, Apellaniz, Delmira, Bologna-Molina, Ronell   +3 more
core  

Chronic replication stress-mediated genomic instability disrupts placenta development in mice.

PLoS Genetics
Abnormal placentation drives many pregnancy-related pathologies and poor fetal outcomes, but the underlying molecular causes are understudied. Here, we show that persistent replication stress due to mutations in the MCM2-7 replicative helicase disrupts ...
Mumingjiang Munisha, Rui Huang, Jordan Khan, John C Schimenti   +3 more
doaj   +1 more source

Replication licensing regulated by a short linear motif within an intrinsically disordered region of origin recognition complex

Nature Communications
In eukaryotes, the origin recognition complex (ORC) faciliates the assembly of pre-replicative complex (pre-RC) at origin DNA for replication licensing.
Yue Wu, Qiongdan Zhang, Yuhan Lin, Wai Hei Lam, Yuanliang Zhai   +4 more
doaj   +1 more source

Chromosomal Mcm2-7 distribution and the genome replication program in species from yeast to humans. [PDF]

PLoS Genet, 2021
Foss EJ, Sripathy S, Gatbonton-Schwager T, Kwak H, Thiesen AH, Lao U, Bedalov A.   +6 more
europepmc   +1 more source

Investigating the Mechanism of Activation of the Mcm2-7 Replicative Helicase [PDF]

, 2015
DNA replication initiation is co-ordinated with progression through the cell cycle via a two-step mechanism. The first step, termed origin licensing, involves the assembly of a pre-replicative complex (pre-RC) at origins of replication, in which the Mcm2-
Deegan, TD
core  

Dormant origins licensed by excess Mcm2-7 are required for human cells to survive replicative stress

, 2007
In late mitosis and early G1, Mcm2-7 complexes are loaded onto DNA to license replication origins for use in the upcoming S phase. However, the amount of Mcm2-7 loaded is in significant excess over the number of origins normally used.
Blow, J. Julian; id_orcid, Jackson, Dean A., Ge, Xin Quan, Blow, J. Julian   +3 more
core   +1 more source

Mechanisms of MCM2-7 helicase activation and initial DNA melting at near base-pair resolution. [PDF]

Nat Commun
Weekes C, Willerding L, Khadayate SP, Liebl K, Mossler A, Montoya A, Rauthe V, Karimi MM, Zacharias M, Ulrich HD, Speck C, Reuter LM.   +11 more
europepmc   +2 more sources

Replikatiivse helikaasikompleksi MCM2-7 subühikute taseme reguleerimine oksüdatiivse stressi sensorvalk KEAP1 poolt [PDF]

, 2016
Replikatiivne helikaasikompleks MCM2-7 omab väga olulist rolli DNA replikatsiooni initsiatsioonis ja selle regulatsioonis. Oksüdatiivse stressi sensorvalk KEAP1 interakteerub helikaasi subühikutega MCM3 ja MCM7, kuid selle interaktsiooni roll rakus ei ...
Raja, Gerda
core  

MCM2-7 proteins promote NF-κB transcriptional activity through cooperative promoter recruitment. [PDF]

Biosci Rep
Hong X, Sui M, Li Q, Lu YJ, Nie YH, Li YP, Li WL, Yue XX, Xu J, Billadeau D, Wang T, Deng ZH.   +11 more
europepmc   +1 more source