Results 81 to 90 of about 11,749,169 (183)

An investigation into minichromosomal maintenance proteins (MCMs) for the diagnosis of prostate cancer, as a possible alternative to prostate specific antigen (PSA) [PDF]

, 2005
The current strategy for the diagnosis of prostate cancer includes serum prostate specific antigen (PSA) measurement. There is however debate into its specificity and sensitivity, so new diagnostic markers are under investigation.
Watkins, Jane Louise
core  

Dynamic‐FLPs Enabled by Orbital Hybridization Tuning: Boosting 100% CO Selectivity for Dilute CO2‐to‐CO Conversion

Carbon Energy, EarlyView.
This study, for the first time, constructs photostructured dynamic frustrated Lewis pairs (DFLPs) via a p‐p orbital hybridization regulation strategy, achieving the 100% reduction of low‐concentration CO₂ to CO and breaking the stability‐activity trade‐off.
Xiao‐hong Wang, Wen‐qing Gao, Jin‐li Liu, Yi‐lei Li, Hui‐ying Mu, Ying Liu, Fa‐tang Li   +6 more
wiley   +1 more source

A Checkpoint-Related Function of the MCM Replicative Helicase Is Required to Avert Accumulation of RNA:DNA Hybrids during S-phase and Ensuing DSBs during G2/M. [PDF]

PLoS Genetics, 2016
The Mcm2-7 complex is the catalytic core of the eukaryotic replicative helicase. Here, we identify a new role for this complex in maintaining genome integrity.
Sriram Vijayraghavan, Feng-Ling Tsai, Anthony Schwacha   +2 more
doaj   +1 more source

Optical mapping reveals a higher level of large‐scale structural variants in a family with paternally transmitted myotonic dystrophy and independent Parkinson's disease

The Journal of Pathology, EarlyView.
Abstract Myotonic dystrophy type 1 (DM1) is a clinically challenging multisystem neuromuscular hereditary disorder, with generational increase in severity and earlier age at onset. It is caused by an unstable cytosine‐thymine‐guanine repeat expansion at the DMPK locus, accompanied by associated genetic and epigenetic modifications.
Md Mehedi Hasan, Jenna Craddock, Tingting Gong, Ruth J Lyons, Igor Stevanovski, Sanjog R Chintalaphani, Ira W Deveson, Weerachai Jaratlerdsiri, Kishore R Kumar, Vanessa M Hayes   +9 more
wiley   +1 more source

Model of Mcm2-7.

, 2013
(A) Two views of the Mcm2-7 hexamer: on the left, looking through the central channel from the C-terminal end, and on the right, rotated 90° about a horizontal axis. The N- and C-terminal domains of the subunits are indicated.
Tina L. Sing (496154), Christopher J. Brandl (496156), Brian H. Shilton (496155), Megan J. Davey (496157), Simon K. W. Lam (496153), Xiaoli Ma (88826)   +5 more
core   +1 more source

Optic nerve sheath meningioma exhibits neural niche‐associated transcriptomic features and rare copy number variation‐linked evolution

Brain Pathology, Volume 36, Issue 4, July 2026.
Optic nerve sheath meningiomas are typically NF2‐intact with few copy number alterations and are generally clinically indolent. Rare aggressive recurrences are associated with progressive accumulation of copy number variations, including CDKN2A/B homozygous deletion, 1q gain, and 14q loss.
Daisuke Sato, Satoru Miyawaki, Yu Sakai, Kenta Ohara, Yu Teranishi, Yudai Hirano, Motoyuki Umekawa, Takahiro Tsuchiya, Shotaro Ogawa, So Hirata, Hiroki Hongo, Hideaki Ono, Daisuke Komura, Tetsuo Ushiku, Shumpei Ishikawa, Nobuhito Saito   +15 more
wiley   +1 more source

Characterization of Leishmania donovani MCM4: expression patterns and interaction with PCNA. [PDF]

PLoS ONE, 2011
Events leading to origin firing and fork elongation in eukaryotes involve several proteins which are mostly conserved across the various eukaryotic species.
Neha Minocha, Devanand Kumar, Kalpana Rajanala, Swati Saha   +3 more
doaj   +1 more source

Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells

FEBS Open Bio, Volume 16, Issue 6, Page 1181-1196, June 2026.
UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca, Anna Tricarico, Martina Furfaro, Priyam Ghosh, Ennio Prosperi, Lucia Anna Stivala, Ornella Cazzalini   +6 more
wiley   +1 more source

Reconstitution and analysis of Mcm2-7_3K499A.

, 2013
(A) Individual Mcm subunits were expressed in bacteria, purified, and mixed in an equimolar ratio to reconstitute the hexameric complex. The Mcm2-7 complexes were then subjected to gel filtration chromatography, and fractions analyzed by SDS-PAGE.
Tina L. Sing (496154), Christopher J. Brandl (496156), Brian H. Shilton (496155), Megan J. Davey (496157), Simon K. W. Lam (496153), Xiaoli Ma (88826)   +5 more
core   +1 more source

DMAP1 Deficiency Suppresses Lung Cancer Progression by Destabilizing Replication Fork and Activating IFN Signaling‐Mediated Anti‐tumor Immunity

Advanced Science, Volume 13, Issue 33, 15 June 2026.
Lung cancer remains the leading cause of cancer‐related death. We investigated the role of the epigenetic regulator DMAP1 in NSCLC and found that its loss induces replication stress and DNA damage. This in turn activates type I IFN signaling via the cGAS–STING pathway and transcriptional ISG de‐repression, enhancing anti‐tumor immune responses ...
Kan Huang, Xi Dai, Shuaihu Li, Yingxue Chen, Yaxin Yu, Lin Wang, Kun Liu, Shuhan Lyu, Chongyang Li, Yihua Sun, Fei Li   +10 more
wiley   +1 more source