Results 61 to 70 of about 11,749,169 (183)
Expression and Prognostic Value of MCM Family Genes in Osteosarcoma
Frontiers in Molecular Biosciences, 2021 We performed a detailed cancer VS normal analysis to explore the expression and prognostic value of minichromosome maintenance (MCM) proteinsin human sarcoma.
Jian Zhou +6 more
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Post-transcriptional homeostasis and regulation of MCM2–7 in mammalian cells [PDF]
Nucleic Acids Research, 2012 The MiniChromosome Maintenance 2-7 (MCM2-7) complex provides essential replicative helicase function. Insufficient MCMs impair the cell cycle and cause genomic instability (GIN), leading to cancer and developmental defects in mice. Remarkably, depletion or mutation of one Mcm can decrease all Mcm levels.
Chuang, Chen-Hua +5 more
openaire +2 more sources
BMC Biology, 2021 Background Faithful DNA replication is essential to maintain genomic stability in all living organisms, and the regulatory pathway for DNA replication initiation is conserved from yeast to humans.
Kyu Joon Lee, Ziyin Li
doaj +1 more source
Modulation of Mcm2–7 activity by Cdt1
The FASEB Journal, 2013 Genome duplication occurs once and only once in each cell cycle. During G1 phase, pre‐replicative complexes (pre‐RC), composed of ORC, Cdc6, Cdt1 and Mcm2–7, are assembled at replication origins. Mcm2–7 is the replicative helicase in eukaryotic cells; however, it does not unwind DNA in the pre‐RC.
Lance F DaSilva +3 more
openaire +1 more source
The PS1 hairpin of Mcm3 is essential for viability and for DNA unwinding in vitro. [PDF]
PLoS ONE, 2013 The pre-sensor 1 (PS1) hairpin is found in ring-shaped helicases of the AAA+ family (ATPases associated with a variety of cellular activities) of proteins and is implicated in DNA translocation during DNA unwinding of archaeal mini-chromosome maintenance
Simon K W Lam +5 more
doaj +1 more source
Antagonistic control of DDK binding to licensed replication origins by Mcm2 and Rad53
eLife, 2020 Eukaryotic replication origins are licensed by the loading of the replicative DNA helicase, Mcm2-7, in inactive double hexameric form around DNA. Subsequent origin activation is under control of multiple protein kinases that either promote or inhibit ...
Syafiq Abd Wahab, Dirk Remus
doaj +1 more source
Over expression of minichromosome maintenance genes is clinically correlated to cervical carcinogenesis. [PDF]
PLoS ONE, 2013 Minichromosome Maintenance (MCM) proteins play important roles in cell cycle progression by mediating DNA replication initiation and elongation. Among 10 MCM homologues MCM 2-7 form a hexamer and assemble to the pre-replication complex acting as ...
Mitali Das +7 more
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The structural basis for MCM2–7 helicase activation by GINS and Cdc45 [PDF]
Nature Structural & Molecular Biology, 2011 Two central steps for initiating eukaryotic DNA replication involve loading of the Mcm2-7 helicase onto double-stranded DNA and its activation by GINS-Cdc45. To better understand these events, we determined the structures of Mcm2-7 and the CMG complex by using single-particle electron microscopy.
Alessandro, Costa +6 more
openaire +2 more sources
Incremental genetic perturbations to MCM2-7 expression and subcellular distribution reveal exquisite sensitivity of mice to DNA replication stress. [PDF]
PLoS Genetics, 2010 Mutations causing replication stress can lead to genomic instability (GIN). In vitro studies have shown that drastic depletion of the MCM2-7 DNA replication licensing factors, which form the replicative helicase, can cause GIN and cell proliferation ...
Chen-Hua Chuang +4 more
doaj +1 more source
FEBS Open Bio, 2023 Lung cancer is the most common cause of cancer‐related death worldwide, accounting for 1.8 million deaths annually. Analysis of The Cancer Genome Atlas data showed that all members of the minichromosome maintenance (MCM) family (hexamers involved in DNA ...
Kengo Tanigawa +9 more
doaj +1 more source