Results 101 to 110 of about 3,352 (198)

Merkel cell polyomavirus protein ALTO modulates TBK1 activity to support persistent infection.

PLoS Pathogens
While Merkel cell polyomavirus (MCPyV or MCV) is an abundant virus frequently shed from healthy skin, it is one of the most lethal tumor viruses in immunocompromised individuals, highlighting the crucial role of host immunity in controlling MCPyV ...
Ranran Wang, Taylor E Senay, Tiana T Luo, Wei Liu, James M Regan, Nicholas J H Salisbury, Denise A Galloway, Jianxin You   +7 more
doaj   +1 more source

Increased Detection of Merkel Cell Polyomavirus in Non-Melanoma Skin Cancer and Its Association with Host Immunogenetic Profile

Dermato
Background: Merkel cell polyomavirus (MCPyV) has been established as an etiological agent in Merkel cell carcinoma (MCC), yet its role in other cutaneous neoplasms remains under investigation. The impact of the host’s immunogenetic characteristics on the
Leonardo Ribeiro Alves de Souza, Camila Freze Baez, Thiago Rubim Bellott, Milena Siqueira Pereira, Marianna Tavares Venceslau Gonçalves, Maria Angelica Arpon Marandino Guimarães, Flávio Barbosa Luz, Rafael Brandão Varella   +7 more
doaj   +1 more source

Supplemental Figure 2. Kaplan Meier analysis of survival among MCPyV+ and MCPyV- patients according to the density, composition and distribution of the inflammatory infiltrate. from Density, Distribution, and Composition of Immune Infiltrates Correlate with Survival in Merkel Cell Carcinoma

, 2023
Laurence Feldmeyer, Courtney W. Hudgens, Genevieve Ray-Lyons, Priyadharsini Nagarajan, Phyu P. Aung, Jonathan L. Curry, Carlos A. Torres‐Cabala, Barbara Mino, Jaime Rodriguez‐Canales, Alexandre Reuben, Pei-Ling Chen, Jennifer S. Ko, Steven D. Billings, Roland L. Bassett, Ignacio I. Wistuba, Zachary A. Cooper, Víctor G. Prieto, Jennifer A. Wargo, Michael T. Tetzlaff   +18 more
openalex   +2 more sources

Different Serologic Behavior of MCPyV, TSPyV, HPyV6, HPyV7 and HPyV9 Polyomaviruses Found on the Skin

PLoS ONE, 2013
The polyomavirus family is rapidly expanding with twelve new human viruses identified since 2007. A significant number of the new human polyomaviruses (HPyV) has been found on the skin. Whether these viruses share biological properties and should be grouped together is unknown.
Meijden, E. van der, Bialasiewicz, S., Rockett, R.J., Tozer, S.J., Sloots, T.P., Feltkamp, M.C.W.   +5 more
openaire   +6 more sources

A pilot study of alternative TrkAIII splicing in Merkel cell carcinoma: a potential oncogenic mechanism and novel therapeutic target

Journal of Experimental & Clinical Cancer Research, 2019
Background Merkel cell carcinomas (MCCs) are rare, aggressive, therapeutically-challenging skin tumours that are increasing in incidence and have poor survival rates.
Lucia Cappabianca, Stefano Guadagni, Rita Maccarone, Michela Sebastiano, Alessandro Chiominto, Antonietta Rosella Farina, Andrew Reay Mackay   +6 more
doaj   +1 more source

Merkel Cell Polyomavirus in the Context of Oral Squamous Cell Carcinoma and Oral Potentially Malignant Disorders

Biomedicines
Despite recent advances in prevention, detection and treatment, oral squamous cell carcinoma (OSCC) remains a global health concern, strongly associated with environmental and lifestyle risk factors and infection with oncogenic viruses.
Sara Passerini, Giulia Babini, Elisabetta Merenda, Raffaella Carletti, Daniela Scribano, Luigi Rosa, Antonietta Lucia Conte, Ugo Moens, Livia Ottolenghi, Umberto Romeo, Maria Pia Conte, Cira Rosaria Tiziana Di Gioia, Valeria Pietropaolo   +12 more
doaj   +1 more source

Newly discovered KI, WU, and Merkel cell polyomaviruses: No evidence of mother-to-fetus transmission

Virology Journal, 2010
Background Three* human polyomaviruses have been discovered recently, KIPyV, WUPyV and MCPyV. These viruses appear to circulate ubiquitously; however, their clinical significance beyond Merkel cell carcinoma is almost completely unknown.
Taskinen Helena, Karikoski Riitta, Surcel Heljä-Marja, Kantola Kalle, Chen Tingting, Väisänen Elina, Riipinen Anita, Sadeghi Mohammadreza, Söderlund-Venermo Maria, Hedman Klaus   +9 more
doaj   +1 more source

Incidence and outcomes of Merkel cell carcinoma related to Merkel cell polyomavirus status in Iceland in 1981-2023Capsule Summary

JAAD International
Background: Impact of Merkel cell polyomavirus (MCPyV) associated Merkel cell carcinoma (MCC) has not been assessed in the Icelandic population, nor in a whole population elsewhere.
Maria Vygovska, MD, David Hoyt, BS, Ashley M. Snyder, PhD, MPH, Thorarinn Jonmundsson, MSc, Ashley Khouri, BS, Dev Ram Sahni, MD, MHA, Jonathan Ungar, MD, Jesse M. Lewin, MD, Nicholas Gulati, MD, PhD, Robert G. Phelps, MD, Vikram N. Sahni, MD, Jane M. Grant-Kels, MD, Helgi Sigurdsson, MD, Jon Gunnlaugur Jonasson, MD, Jonas A. Adalsteinsson, MD, PhD   +14 more
doaj   +1 more source

080 Mutational landscape of MCPyV-positive and MCPyV-negative Merkel cell carcinomas with implications for immunotherapy [PDF]

Journal of Investigative Dermatology, 2016
T. Walradt, V. Makarov, R. Doumani, N. Riaz, K. Stafstrom, A. Moshiri, L. Yelistratova, J. Levinsohn, T. Chan, P. Nghiem, R. Lifton, J. Choi   +11 more
openaire   +1 more source

Case of MCPyV-positive Merkel Cell Carcinoma on a Leg Which Spontaneously Regressed after Biopsy

, 2020
Yuka Tanaka, Shuichiro Yasuno, Mikako OKUDA, Yutaka Shimomura   +3 more
openalex   +1 more source