Results 101 to 110 of about 5,841,978 (243)

Cross‐Scale Hierarchical Targeted Delivery System Based on Small‐Scale Magnetic Robots

Advanced Robotics Research, EarlyView.
This article reviews a cross‐scale hierarchical targeted delivery system that integrates magnetic continuum robots and magnetic microrobots. By combining rapid long‐range navigation with precise microscale targeting, the system overcomes key limitations of single‐scale approaches.
Junjian Zhou, Zhiqiang Chen, Yuanbiao Ma, Zhiqiang Tang, Qianqian Wang   +4 more
wiley   +1 more source

Image_3_Occurrence of mcr-1 and mcr-2 colistin resistance genes in porcine Escherichia coli isolates (2010–2020) and genomic characterization of mcr-2-positive E. coli.png

, 2022
IntroductionThe global emergence of plasmid-mediated colistin resistance is threatening the efficacy of colistin as one of the last treatment options against multi-drug resistant Gram-negative bacteria.
Torsten Semmler (106650), Christa Ewers (106664), Lisa Göpel (14239190), Katharina Kerner (3563780), Ellen Prenger-Berninghoff (617468), Rolf Bauerfeind (14239193)   +5 more
core   +1 more source

Biomimetic Hydrogel System Targeting S100A8 Centered Neuroimmune Crosstalk and Hypoxia Induced Neuronal Injury

Advanced Science, EarlyView.
A biomimetic hydrogel (HPC@Gel) was developed for traumatic brain injury repair by combining oxygen‐carrying hemoglobin nanoparticles and anti‐inflammatory carbon quantum dots within a brain‐like matrix. The system alleviated hypoxia, reduced harmful neuroimmune signaling, protected neurons, supported neural regeneration, and improved neurological and ...
Peng Liu, Xiaoyang Wu, Xiaoyin Liu, Yuyan Wang, Shichao Jiang, Kai Wu, Gaowei Li, Jie Ding, Chengheng Wu, Dan Wei, Jing Sun, Hongsong Fan, Liangxue Zhou   +12 more
wiley   +1 more source

Detection of the plasmid-mediated colistin-resistance gene mcr-1 in faecal metagenomes of Dutch travellers [PDF]

, 2016
Background: Recently, the first plasmid-mediated colistin-resistance gene, mcr-1, was reported. Colistin is increasingly used as an antibiotic of last resort for the treatment of infections caused by carbapenem-resistant bacteria, which have been rapidly
Lashof, Astrid M. L. Oude, Stobberingh, Ellen E., Hoebe, Christian J. P. A., Penders, John, Wolffs, Petra F. G., von Wintersdorff, Christian J. H., Hoebe, Christian J. P. A.; id_orcid, Savelkoul, Paul H. M.; id_orcid, Beuken, Erik, Savelkoul, Paul H. M., van Niekerk, Julius M., van Alphen, Lieke B.   +11 more
core   +2 more sources

Frequent convergence of mcr-9 and carbapenemase genes in Enterobacter cloacae complex driven by epidemic plasmids and host incompatibility

, 2022
Convergence of mcr and carbapenemase genes has been sporadically detected in Enterobacter cloacae complex (ECC) with an upward trend. However, the state of the epidemic and underlying mechanism of such convergence has been poorly understood.
Kai Zhou (125548), Tingting Xu (307597), Yuxin Chen (126718), Qiuhui Huang (13109055), Dandan Chen (394689), Yuemei Lu (792212), Weiyuan Wu (792211), Junxi Huang (13109052), Chun-Xu Xue (9998759)   +8 more
core   +1 more source

Identification of an Osteochondral Erosion Process in Gout Driven by Fibrinogen‐Integrin Activation and Local MSU Crystallization

Advanced Science, EarlyView.
Cartilage injury promotes local fibrinogen deposition, which accelerates monosodium urate crystallization and activates integrin‐mediated matrix‐degradation. This self‐amplifying cycle drives gout‐related cartilage erosion. Disrupting fibrinogen deposition or restoring the cartilage barrier could interrupt this vicious cycle.
Hanlin Xu, Simin Bi, Zhechen Liu, Xiaofeng Zhou, Hengwei Qin, Nicola Dalbeth, Minbiao Ji, Yinghui Hua   +7 more
wiley   +1 more source

Image_2_Occurrence of mcr-1 and mcr-2 colistin resistance genes in porcine Escherichia coli isolates (2010–2020) and genomic characterization of mcr-2-positive E. coli.pdf

, 2022
IntroductionThe global emergence of plasmid-mediated colistin resistance is threatening the efficacy of colistin as one of the last treatment options against multi-drug resistant Gram-negative bacteria.
Torsten Semmler (106650), Christa Ewers (106664), Lisa Göpel (14239190), Katharina Kerner (3563780), Ellen Prenger-Berninghoff (617468), Rolf Bauerfeind (14239193)   +5 more
core   +1 more source

Bioengineered Exosome‐Loaded Immunomodulatory Bioadhesive Spray Reverses Liver Fibrosis and Metabolic Dysfunction That Triggers Beneficial Gut‐Liver Crosstalk in Chronic Fatty Liver Disease

Advanced Science, EarlyView.
Umbilical cord stem cell‐derived exosomes encapsulated in an immunomodulatory bioadhesive hydrogel spray enable localized therapy, sustained vesicle delivery, macrophage polarization, suppress systemic inflammation, and mitigate glucose and insulin homeostasis impairments in MAFLD.
Triya Saha, Ayushi Mairal, Shreya Mehrotra, Shiv K. Sarin, Ashok Kumar   +4 more
wiley   +1 more source

Detection of Five mcr-9-Carrying Enterobacterales Isolates in Four Czech Hospitals

, 2020
The aim of this study was to report the characterization of the first mcr positive Enterobacterales isolated from Czech hospitals. In 2019, one Citrobacter freundi and four Enterobacter isolates were recovered from Czech hospitals.
Chudejova K., Papagiannitsis C. C., Kraftova L., Mattioni Marchetti V., Hrabak J., Bitar I.   +5 more
core   +1 more source

Data_Sheet_1_Occurrence of mcr-1 and mcr-2 colistin resistance genes in porcine Escherichia coli isolates (2010–2020) and genomic characterization of mcr-2-positive E. coli.pdf

, 2022
IntroductionThe global emergence of plasmid-mediated colistin resistance is threatening the efficacy of colistin as one of the last treatment options against multi-drug resistant Gram-negative bacteria.
Torsten Semmler (106650), Christa Ewers (106664), Lisa Göpel (14239190), Katharina Kerner (3563780), Ellen Prenger-Berninghoff (617468), Rolf Bauerfeind (14239193)   +5 more
core   +1 more source