Results 91 to 100 of about 1,822,998 (209)

The characterization of mobile colistin resistance (mcr) genes among 33 000 Salmonella enterica genomes from routine public health surveillance in England [PDF]

, 2020
To establish the prevalence of mobile colistin resistance (mcr) genes amongst Salmonella enterica isolates obtained through public health surveillance in England (April 2014 to September 2017), 33 205 S.
Doumith, Michel, Greig, David R, Godbole, Gauri, Hopkins, Katie L, Jenkins, Claire, Hartman, Hassan, Painset, Anais, Chattaway, Marie Anne, Meunier, Daniele, Day, Martin, Dallman, Timothy J, Sia, Cheryll M, Woodford, Neil   +12 more
core   +1 more source

C‐Terminal Functionalization Methods of Amino Acids, Peptides, and Proteins

Chemistry – A European Journal, EarlyView.
C‐terminal functionalization offers powerful routes to peptide and protein diversification, yet epimerization, hydrolysis, and selectivity remain key challenges. This Review surveys enzymatic, decarboxylative, and condensation strategies, highlighting advances toward chemo‐ and regioselective, protecting‐group‐free, atom‐efficient methods applicable to
Jay Hanssens, Mark Lambers, Romano V. A. Orru, Jordy M. Saya   +3 more
wiley   +1 more source

Limited sex‐specific structural alterations across common epilepsies: A worldwide ENIGMA study

Epilepsia, EarlyView.
Abstract Objective Epilepsy is characterized by widespread cortical and subcortical structural alterations beyond the epileptic zone. Importantly, the clinical manifestation of epilepsy, including seizure types, psychiatric comorbidities, and treatment responses, has been shown to differ between sexes. However, sex differences in structural alterations
Huantao Wen, Bin Wan, Taha Gholipour, Ke Xie, Judy Chen, Bianca Serio, Meike D. Hettwer, Marina K. M. Alvim, Donatello Arienzo, Rafael Batista João, Tobias Bauer, Andrea Bernasconi, Neda Bernasconi, Paolo Bonanni, Maria Eugenia Caligiuri, Fernando Cendes, Raphaël Christin, Luis Concha, Arielle Dascal, Edward Davoodi Boyd, Orrin Devinsky, Niels K. N. Focke, Francesco Fortunato, Marian Galovic, Antonio Gambardella, Renzo Guerrini, Sean N. Hatton, Mirana Iliza, Sara Inati, Victoria Ives‐Deliperi, Robert‐Paul Juster, Jonathan K. Kleen, Mohamad Z. Koubeissi, Angelo Labate, Sara Larivière, Meng Law, Matteo Lenge, Stefano Meletti, Patrick B. Moloney, Marlo Naish, Alexander Ngo, Terence J. O'Brien, Raluca Pana, Sofia Panzeri, Heath Pardoe, Erik H. U. Rauf, Antonella Riva, Raúl Rodríguez‐Cruces, Jessica Royer, Theodor Rüber, Ella Sahlas, Lucas Scárdua‐Silva, Kai Michael Schubert, Leigh N. Sepeta, Mariasavina Severino, Benjamin Sinclair, Hamid Soltanian‐Zadeh, Travis Stoub, Pasquale Striano, Sophia I. Thomopoulos, Nina V. Valientes, Anna Elisabetta Vaudano, Lucy Vivash, Clarissa L. Yasuda, Paul M. Thompson, Sanjay M. Sisodiya, Carrie R. McDonald, Boris C. Bernhardt, Sofie L. Valk   +68 more
wiley   +1 more source

First Report of bla_VIM-4- and mcr-9-Coharboring Enterobacter Species Isolated from a Pediatric Patient

mSphere, 2019
An Enterobacter hormaechei isolate harboring blaVIM-4 and mcr-9 was recovered from a pediatric patient in a U.S. hospital. The blaVIM-4 and mcr-9 genes are carried on the same IncH12 plasmid, pME-1a.
Kalyan D. Chavda, Lars F. Westblade, Michael J. Satlin, Andrew C. Hemmert, Mariana Castanheira, Stephen G. Jenkins, Liang Chen, Barry N. Kreiswirth   +7 more
doaj   +1 more source

Abnormal functional connectivity patterns in temporal lobe epilepsy—An international ENIGMA‐epilepsy study

Epilepsia Open, EarlyView.
Abstract Objectives Temporal lobe epilepsy (TLE) impacts multiple brain networks. Aberrant functional connectivity has been demonstrated in resting‐state networks (RSNs) that mediate higher brain functions in TLE. This study aimed to identify the reproducible patterns of altered functional connectivity in TLE in a large, international cohort through ...
Victoria Ives‐Deliperi, Jonathan Ipser, James T. Butler, Heath Pardoe, Hamid Soltanian‐Zadeh, Christian Rummel, Roland Wiest, Simon S. Keller, Barbara A. K. Kreilkamp, Anna Elisabetta Vaudano, Alice Ballerini, Stefano Meletti, Gerard Hall, Peter Taylor, Luis Concha, Alfonso Fajardo‐Valdez, Raphael Fernandes Casseb, Fernando Cendes, Clarissa L. Yasuda, Louis Lemieux, John S. Duncan, Esmaeil Davoodi‐Bodj, Orrin Devinsky, Sophia I. Thomopoulos, Dan J. Stein, Paul M. Thompson, Sanjay M. Sisodiya, Taha Gholipour, Carrie R. McDonald   +28 more
wiley   +1 more source

Illuminating Streptomyces: Raman Spectroscopy for Antibiotic Detection and Monitoring

Journal of Raman Spectroscopy, EarlyView.
Raman spectroscopy provides a non‐destructive, label‐free approach for studying the chemical diversity of Streptomyces. This review presents its application from detection to chemical characterization of secondary metabolites and monitoring of biosynthetic processes.
Adéla Mikulová, Jan Bobek, Martin Kizovský, Markéta Benešová, Ota Samek, Pavlína Modlitbová, Zdeněk Pilát   +6 more
wiley   +1 more source

Analysis of Carbohydrates and Glycoconjugates by Matrix‐Assisted Laser Desorption/Ionization Mass Spectrometry: An Update for 2023–2024

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The use of MALDI mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this comprehensive review is the twelfth update of the original article published in 1999 and brings coverage of the literature to the end of 2024.
David J. Harvey
wiley   +1 more source

Proteomic Analysis of Mixed Cell Membrane Extracts From Triple‐Negative Breast Cancer Cell Lines Revealed Broad Metabolic Reprogramming Associated With Tumor Progression

PROTEOMICS, EarlyView.
ABSTRACT Triple‐negative breast cancer (TNBC) represents the most aggressive subtype with limited therapeutic options and the poorest clinical outcomes. Using high‐resolution nUPLC‐QTOF‐MS/MS, we performed comprehensive proteomic profiling of TNBC cell lines representing disease progression stages: HCC‐1937 (stage IIB), HCC‐1599 (stage IIIA), and MDA ...
Claudia Sissely Chaviano‐Montes de Oca, Violeta Larios‐Serrato, María Luisa Labra‐Barrios, Emmanuel Ríos‐Castro, Carlos Alberto Castañón‐Sánchez, Rodolfo Moreno‐Castillo, Erika Beatriz Ángeles‐Morales, Juan Pedro Luna‐Arias   +7 more
wiley   +1 more source

Application of Non‐Isothermal Network Theory With Curved‐Channel Element Characteristics to Predict Melt Conveying in High‐Performance Single‐Screw Extruders

Journal of Polymer Science, EarlyView.
This study presents a fast and accurate calculation tool to predict conveying of polymer melts in single‐screw extruders. Integrating generalized sub‐models into network theory allows to represent the complex screw shapes and material behavior more realistically. Tests on an industrial extruder show close agreement with experiments, outperforming older
Daniel Herzog, Wolfgang Roland, Christian Marschik, Gerald Berger‐Weber   +3 more
wiley   +1 more source

Genetic environment of colistin resistance genes mcr-1 and mcr-3 in Escherichia coli from one pig farm in China

, 2019
The aim of this study was to assess the presence of mobile colistin resistance in bacteria isolated from the swine production environment and to analyze the genomic environment of the new colistin resistance gene mcr-3.
Wang, Yang, Schwarz, Stefan, Walsh, Timothy R., Wang, Zheng, Fu, Yulin, Yin, Wenjuan, Jiang, Haiyang, He, Junjia, Zhou, Yuqing, Wang, Shaolin   +9 more
core   +1 more source