Results 71 to 80 of about 1,695,806 (215)

Rapid detection and quantification of plasmid-mediated colistin resistance genes (mcr-1 to mcr-5) by real-time PCR in bacterial and environmental samples [PDF]

, 2020
Aim: The aim of the study was to validate a rapid method to detect and quantify colistin resistance genes (mcr-1 to mcr-5) by real-time polymerase chain reaction (RT-PCR) in diverse matrices. Methods and results: The detection limit of two newly designed
Grilli G., Apostolakos I., Laconi A., Laconi, A, Carraro, L, Tolosi, R, Cagnardi P., Tolosi R., Cagnardi, P, Carraro L., Grilli, G, Apostolakos, I, Piccirillo A., Piccirillo, A   +13 more
core   +1 more source

Emergence of mcr-1 and mcr-3 variants coding for plasmid-mediated colistin resistance in Escherichia coli isolates from food- producing animals in South Korea

International Journal of Infectious Diseases, 2018
We hereby report the first characterization of mcr-3 gene from healthy animals in South Korea. Out of 636 E. coli isolates, collected between 2014- 2017, nine colistin resistant isolates were screened for the presence of mcr-1 and mcr-3 genes. Nine (1.4%)
Kuastros Mekonnen Belaynehe, Seung Won Shin, Kyung Yoon Park, Ji Young Jang, Ho Geun Won, In Joong Yoon, Han Sang Yoo   +6 more
doaj   +1 more source

mcr-Colistin Resistance Genes Mobilized by IncX4, IncHI2, and IncI2 Plasmids in Escherichia coli of Pigs and White Stork in Spain

Frontiers in Microbiology, 2020
Colistin has become the last-line antimicrobial for the treatment of multidrug resistant (MDR) Enterobacterales in human medicine. To date, several colistin resistance genes have been described. Of them mcr-1 is disseminated worldwide in Escherichia coli
Lourdes Migura-Garcia, Lourdes Migura-Garcia, Juan J. González-López, Jaime Martinez-Urtaza, J. R. Aguirre Sánchez, J. R. Aguirre Sánchez, A. Moreno-Mingorance, A. Perez de Rozas, Ursula Höfle, Y. Ramiro, Narjol Gonzalez-Escalona   +10 more
doaj   +1 more source

Lanthanum Carbonate Nanosheets Based Colloidal Hydrogel for Modulating Innate & Adaptive Tumor Immunotherapy by Augmented Cellular Pyroptosis

Advanced Science, EarlyView.
The Gela/decitabine/La2(CO3)3 colloidal (GDLC) hydrogel developed here could reverse the epigenetic silencing of the GSDME gene by the synergistic interaction between DAC and La3+, while concurrently activating caspase‐3, thus facilitating pyroptosis induction under the tumor microenvironment.
Yang Hong, Haitao Wu, Weitao Wang, Xuan Zhang, Qian Chen, Yaoyu Hu, Zhengbao Zha   +6 more
wiley   +1 more source

Rapid multiplex polymerase chain reaction for detection of mcr-1 to mcr-5 genes [PDF]

, 2019
A rapid (total time 
Lescata, Mathilde, Nordmann, Patrice, Poirel, Laurent   +2 more
core  

Multiplex PCR for detection of plasmid-mediated colistin resistance determinants, mcr-1, mcr-2, mcr-3, mcr-4 and mcr-5 for surveillance purposes [PDF]

, 2018
Background and aim: Plasmid-mediated colistin resistance mechanisms have been identified worldwide in the past years. A multiplex polymerase chain reaction (PCR) protocol for detection of all currently known transferable colistin resistance genes (mcr-1 ...
Hammerl, Jens Andre, Sophie A Granier, Cristina De Frutos Escobar, Kjeldgaard, Jette,, Ana Rita Rebelo, Carattoli, Alessandra, Borowiak, Maria, Valeria Bortolaia, Maria Borowiak, Hendriksen, Rene S., Patricia Alba, Hendriksen, Rene,, Hansen, Inge,, Malorny, Burkhard, Granier, Sophie, Surbhi Malhotra-Kumar, Antonio Battisti, De Frutos Escobar, Cristina, Franco, Alessia, Inge M Hansen, Rene S Hendriksen, Hammerl, Jens,, Pedersen, Susanne,, Leekitcharoenphon, Pimlapas, Hansen, Inge M., Rebelo, Ana Rita, de Frutos, Cristina, Jette S Kjeldgaard, Alessia Franco, Pedersen, Susanne K., Karlsmose Pedersen, Susanne, Malhotra-Kumar, Surbhi, Kjeldgaard, Jette S., Pimlapas Leekitcharoenphon, Alba, Patricia, Burkhard Malorny, Rebelo, Ana-Rita, Alessandra Carattoli, Granier, Sophie A., Beatriz Guerra, Perrin-Guyomard, Agnes, Battisti, Antonio, Bortolaia, Valeria, Escobar, Susanne K Pedersen, Agnes Perrin-Guyomard, Guerra, Beatriz, Laura Villa, Malhotra, Surbhi, Jens Andre Hammerl, Villa, Laura   +50 more
core   +3 more sources

mcr-1 and mcr-2 (mcr-6.1) variant genes identified in Moraxella species isolated from pigs in Great Britain from 2014 to 2015 [PDF]

Journal of Antimicrobial Chemotherapy, 2017
To determine the occurrence of mcr-1 and mcr-2 genes in Gram-negative bacteria isolated from healthy pigs in Great Britain.Gram-negative bacteria (n = 657) isolated from pigs between 2014 and 2015 were examined by WGS.Variants of mcr-1 and mcr-2 were identified in Moraxella spp.
AbuOun, M, Stubberfield, E, Duggett, N, Kirchner, M, Dormer, L, Nunez-Garcia, J, Randall, L, Lemma, F, Crook, D, Teale, C, Smith, R, Anjum, M   +11 more
openaire   +4 more sources

Transforming Lives: The First 18 Months of the MCR Pathways Mentoring Programme

, 2014
The programme is school-based and aimed at young people who are ‘looked after’ by the local authority or have previously been looked after. The MCR Pathways Mentoring Programme involves four partners: the MCR Charitable Foundation; Glasgow City Council ...
Siebelt, L., Mitchell, I., Fassetta, G.
core   +6 more sources

An Injectable Metal‐Drug Supramolecular Condensate Enables Radiosensitization and Systemic Antitumor Immunity for Post‐Surgical Osteosarcoma Therapy

Advanced Science, EarlyView.
This work designed an injectable metal‐drug supramolecular condensate formed from hafnium ions and alendronate (Hf‐ALN) and loaded with the COX‐2 inhibitor celecoxib (CXB) for synergistic radioimmunotherapy of postoperative osteosarcoma. Mechanistically, upon X‐ray irradiation, Hf enhances radiation energy deposition, ROS generation, and DNA damage ...
Tianhua Xiao, Zunlei Gong, Chuke Chen, Hui Yu, Yu Cai, Can Liu, Hongkai Huang, Ying Li, Jinyuan Guan, Le Wang, Chengyun Ning, Guoxin Tan, Lei Zhou   +12 more
wiley   +1 more source

Layer‐Specific Dermal and Subcutaneous Delivery via Modular LNP–Hydrogel‐Integrated Threaded Microneedles

Advanced Science, EarlyView.
Guided by spatial transcriptomics and clinical validation, a threaded microneedle platform enables precise layer‐specific delivery across the dermis and subcutaneous tissue. By addressing distinct pathogenic remodeling in different skin layers, this strategy coordinates compartment‐specific intervention, restores tissue architecture, and offers a ...
Fangzhou Xie, Yixiang Zhang, Shifeng Ling, Yuxuan Huang, Yingying Wei, Rao Fu, Jiahao He, Baikun Liu, Lucia Zhou, Kaifeng Huo, Yida Wang, Qingfeng Li, Yawei Du, Wenguo Cui, Yun Xie   +14 more
wiley   +1 more source