Results 71 to 80 of about 1,822,998 (209)

Source of isolates examined for the mcr-1 and mcr-2 genes used in this study.

, 2017
Source of isolates examined for the mcr-1 and mcr-2 genes used in this study.
Nicolle Lima Barbieri (314101), Yvonne Wannemuehler (427663), Lisa K. Nolan (147070), Ashraf Hussein (3815464), Catherine M. Logue (294873), Shi-gan Yan (3815473), Daniel W. Nielsen (3815470), Tia Cavender (3815467)   +7 more
core   +1 more source

A Multiplex SYBR Green Real-Time PCR Assay for the Detection of Three Colistin Resistance Genes from Cultured Bacteria, Feces, and Environment Samples

Frontiers in Microbiology, 2017
The aim of the study was to develop a multiplex assay for rapid detection of mcr-1, mcr-2, and mcr-3, a group of genes of conferring resistance to colistin mediated by plasmid in Enterobacteriaceae.
Jiyun Li, Jiyun Li, Xiaomin Shi, Wenjuan Yin, Yang Wang, Yang Wang, Zhangqi Shen, Shuangyang Ding, Shuangyang Ding, Shaolin Wang, Shaolin Wang   +10 more
doaj   +1 more source

An Injectable Metal‐Drug Supramolecular Condensate Enables Radiosensitization and Systemic Antitumor Immunity for Post‐Surgical Osteosarcoma Therapy

Advanced Science, EarlyView.
This work designed an injectable metal‐drug supramolecular condensate formed from hafnium ions and alendronate (Hf‐ALN) and loaded with the COX‐2 inhibitor celecoxib (CXB) for synergistic radioimmunotherapy of postoperative osteosarcoma. Mechanistically, upon X‐ray irradiation, Hf enhances radiation energy deposition, ROS generation, and DNA damage ...
Tianhua Xiao, Zunlei Gong, Chuke Chen, Hui Yu, Yu Cai, Can Liu, Hongkai Huang, Ying Li, Jinyuan Guan, Le Wang, Chengyun Ning, Guoxin Tan, Lei Zhou   +12 more
wiley   +1 more source

Emergence of mcr-1 and mcr-3 variants coding for plasmid-mediated colistin resistance in Escherichia coli isolates from food- producing animals in South Korea

International Journal of Infectious Diseases, 2018
We hereby report the first characterization of mcr-3 gene from healthy animals in South Korea. Out of 636 E. coli isolates, collected between 2014- 2017, nine colistin resistant isolates were screened for the presence of mcr-1 and mcr-3 genes. Nine (1.4%)
Kuastros Mekonnen Belaynehe, Seung Won Shin, Kyung Yoon Park, Ji Young Jang, Ho Geun Won, In Joong Yoon, Han Sang Yoo   +6 more
doaj   +1 more source

mcr-Colistin Resistance Genes Mobilized by IncX4, IncHI2, and IncI2 Plasmids in Escherichia coli of Pigs and White Stork in Spain

Frontiers in Microbiology, 2020
Colistin has become the last-line antimicrobial for the treatment of multidrug resistant (MDR) Enterobacterales in human medicine. To date, several colistin resistance genes have been described. Of them mcr-1 is disseminated worldwide in Escherichia coli
Lourdes Migura-Garcia, Lourdes Migura-Garcia, Juan J. González-López, Jaime Martinez-Urtaza, J. R. Aguirre Sánchez, J. R. Aguirre Sánchez, A. Moreno-Mingorance, A. Perez de Rozas, Ursula Höfle, Y. Ramiro, Narjol Gonzalez-Escalona   +10 more
doaj   +1 more source

mcr-1 and mcr-2 (mcr-6.1) variant genes identified in Moraxella species isolated from pigs in Great Britain from 2014 to 2015 [PDF]

Journal of Antimicrobial Chemotherapy, 2017
To determine the occurrence of mcr-1 and mcr-2 genes in Gram-negative bacteria isolated from healthy pigs in Great Britain.Gram-negative bacteria (n = 657) isolated from pigs between 2014 and 2015 were examined by WGS.Variants of mcr-1 and mcr-2 were identified in Moraxella spp.
AbuOun, M, Stubberfield, E, Duggett, N, Kirchner, M, Dormer, L, Nunez-Garcia, J, Randall, L, Lemma, F, Crook, D, Teale, C, Smith, R, Anjum, M   +11 more
openaire   +4 more sources

Plasmid maps of pACYC-Para-MCR-1 and pACYC-NP-MCR-1.

, 2023
The plasmid for expressing MCR-1 or M6 under the regulation of arabinose promoter was shown as (A), and the one for expressing target proteins under the regulation of MCR-1 native promoter was shown as (B).
Chenchen Zhang (324804), Siyuan Feng (5998040), Yaxin Li (312731), Lingxuan Lyu (17628265), Yohei Doi (188766), Wanfei Liang (8610954), Fang Bai (1612534), Lin Wang (11986), Lan-Lan Zhong (9702537), Dianrong Zhou (11816537), Jiachen Li (669381), Hui Zhao (7395), Yong Chen (109188), Nicole Stoesser (220513), Guo-Bao Tian (3365051), Lujie Liang (8610960), Wenjing Wei (525144)   +16 more
core   +1 more source

Layer‐Specific Dermal and Subcutaneous Delivery via Modular LNP–Hydrogel‐Integrated Threaded Microneedles

Advanced Science, EarlyView.
Guided by spatial transcriptomics and clinical validation, a threaded microneedle platform enables precise layer‐specific delivery across the dermis and subcutaneous tissue. By addressing distinct pathogenic remodeling in different skin layers, this strategy coordinates compartment‐specific intervention, restores tissue architecture, and offers a ...
Fangzhou Xie, Yixiang Zhang, Shifeng Ling, Yuxuan Huang, Yingying Wei, Rao Fu, Jiahao He, Baikun Liu, Lucia Zhou, Kaifeng Huo, Yida Wang, Qingfeng Li, Yawei Du, Wenguo Cui, Yun Xie   +14 more
wiley   +1 more source

Seeing the Chemistry of Biomolecular Condensates: In Situ Mapping of Composition and Water Content

Advanced Science, EarlyView.
Raman hyperspectral imaging combined with spectral phasor analysis enables a label‐free quantification of proteins, polymers and water density within individual biomolecular condensates. By transforming complex vibrational fingerprints into intuitive compositional maps, the approach reveals the high water content and structural heterogeneity of ...
E. Sabri, A. Mangiarotti, C. N. Z. Schmitt, R. Dimova   +3 more
wiley   +1 more source

Multiplex PCR for detection of plasmid-mediated colistin resistance determinants, mcr-1, mcr-2, mcr-3, mcr-4 and mcr-5 for surveillance purposes [PDF]

, 2018
Background and aim: Plasmid-mediated colistin resistance mechanisms have been identified worldwide in the past years. A multiplex polymerase chain reaction (PCR) protocol for detection of all currently known transferable colistin resistance genes (mcr-1 ...
Hammerl, Jens Andre, Sophie A Granier, Cristina De Frutos Escobar, Kjeldgaard, Jette,, Ana Rita Rebelo, Carattoli, Alessandra, Borowiak, Maria, Valeria Bortolaia, Maria Borowiak, Hendriksen, Rene S., Patricia Alba, Hendriksen, Rene,, Hansen, Inge,, Malorny, Burkhard, Granier, Sophie, Surbhi Malhotra-Kumar, Antonio Battisti, De Frutos Escobar, Cristina, Franco, Alessia, Inge M Hansen, Rene S Hendriksen, Hammerl, Jens,, Pedersen, Susanne,, Leekitcharoenphon, Pimlapas, Hansen, Inge M., Rebelo, Ana Rita, de Frutos, Cristina, Jette S Kjeldgaard, Alessia Franco, Pedersen, Susanne K., Karlsmose Pedersen, Susanne, Malhotra-Kumar, Surbhi, Kjeldgaard, Jette S., Pimlapas Leekitcharoenphon, Alba, Patricia, Burkhard Malorny, Rebelo, Ana-Rita, Alessandra Carattoli, Granier, Sophie A., Beatriz Guerra, Perrin-Guyomard, Agnes, Battisti, Antonio, Bortolaia, Valeria, Escobar, Susanne K Pedersen, Agnes Perrin-Guyomard, Guerra, Beatriz, Laura Villa, Jens Andre Hammerl, Villa, Laura, Pedersen, Susanne, K., Carattoli A, Hendriksen, Rene, S, Leekitcharoenphon P, Hendriksen RS, Hammerl JA, Malorny B, Borowiak M, Battisti A, Rebelo AR, Guerra B, Escobar and Malhotra-Kumar S, Bortolaia V, Granier SA, Kjeldgaard, Jette, S., Hansen IM, de Frutos C, Perrin-Guyomard A, Alba P, Pedersen SK, Villa L, Hammerl, Jens, Andre, Hansen, Inge, M, Kjeldgaard JS, Franco A   +74 more
core   +3 more sources