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Culture-Independent Quantitative PCR Detected Mobilized Colistin Resistance Genes (Mcr-1, Mcr-2, Mcr-3, Mcr-4, and Mcr-5) in Chicken Gut Contents in Bangladesh [PDF]

Sci
Inappropriate antimicrobial use in food animal farming propels antimicrobial resistance (AMR) that affects all health domains. Colistin is a ‘Reserve’ antibiotic for human treatment to be conserved for multidrug-resistant pathogens; however, it is being ...
Salequl Islam, Brian Godman, Mdasief Zihadi   +2 more
exaly   +2 more sources

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Plasmid-Mediated Colistin-Resistance Genes: Mcr

Trends in Microbiology
Colistin is regarded as a last-line drug against serious infections caused by multidrug-resistant Gram-negative bacterial pathogens. Therefore, the emergence of mobile colistin resistance (mcr) genes has attracted global concern and led to policy changes for the use of colistin in food animals across many countries.
Jian-Hua Liu, Jianzhong Shen, Timothy R. Walsh   +2 more
exaly   +3 more sources

Co-occurrence of mcr-1, mcr-3, mcr-7 and clinically relevant antimicrobial resistance genes in environmental and fecal samples

Archives of Microbiology, 2020
Multidrug-resistant bacteria harboring different antimicrobial resistance genes (ARGs) have been detected worldwide. The association of plasmid-mediated colistin resistance genes (mcr-like) and other ARGs in bacteria isolated from animals is a huge concern worldwide.
Lucas David Rodrigues dos Santos, João Pedro Rueda Furlan, Micaela Santana Ramos, Inara Fernanda Lage Gallo, Lucas Victor Pereira de Freitas, Eliana Guedes Stehling   +5 more
openaire   +2 more sources

Decoding the Origins, Spread, and Global Risks of Mcr-9 Gene

EBioMedicine
The global spread of the plasmid-mediated mcr (mobilized colistin resistance) gene family presents a significant threat to the efficacy of colistin, a last-line defense against numerous Gram-negative pathogens. The mcr-9 is the second most prevalent variant after mcr-1.A dataset of 698 mcr-9-positive isolates from 44 countries is compiled.
Longyang Jin, Ruobing Wang, Meng Cai
exaly   +3 more sources

Genetic basis of chromosomally-encoded mcr-1 gene

International Journal of Antimicrobial Agents, 2018
Compared with plasmid-borne mcr-1, the occurrence of chromosomally-encoded mcr-1 is rare although it has been reported in several cases. This study aimed to investigate the genetic features of chromosomally-encoded mcr-1 among Escherichia coli strains as well as the potential genetic basis governing mobilisation of mcr-1 in bacterial chromosomes.
Ruichao, Li, Hua, Yu, Miaomiao, Xie, Kaichao, Chen, Ning, Dong, Dachuan, Lin, Edward Wai-Chi, Chan, Sheng, Chen   +7 more
openaire   +2 more sources

Identification of mobile colistin resistance genes (mcr-1.1, mcr-5 and mcr-8.1) in Enterobacteriaceae and Alcaligenes faecalis of human and animal origin, Nigeria

International Journal of Antimicrobial Agents, 2020
Colistin is a last-resort drug used to treat infections caused by multidrug-resistant Gram-negative bacteria that have developed carbapenem resistance. Emergence and rapid dissemination of the nine plasmid-mediated mobile colistin resistance genes (mcr-1 to mcr-9) has led to fear of pandrug-resistant infections worldwide. To date, there is only limited
Emmanuel O. Ngbede, Anil Poudel, Anwar Kalalah, Yi Yang, Folasade Adekanmbi, Alex A. Adikwu, Andrew M. Adamu, Levi M. Mamfe, Salem T. Daniel, Nicodemus M. Useh, Jacob K.P. Kwaga, Mohammed I. Adah, Patrick Kelly, Patrick Butaye, Chengming Wang   +14 more
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Impact of the colistin resistance gene mcr-1 on bacterial fitness

International Journal of Antimicrobial Agents, 2018
A Klebsiella pneumoniae isolate harbouring a 217 kb IncHI2-type plasmid (pKP2442) encoding the colistin resistance gene mcr-1 was isolated from a leukaemia patient. pKP2442 was mobilised by intragenus and intergenus transconjugation from the clinical isolate to Escherichia coli J53 (transconjugation frequency 6.86 × 10-8 ± 5.57 × 10-8) and K ...
Tietgen, Manuela, Semmler, Torsten, Riedel-Christ, Sara, Kempf, Volkhard A. J., Molinaro, Antonio, Ewers, Christa, Göttig, Stephan   +6 more
openaire   +3 more sources

Colistin resistance gene mcr-1 in gut flora of children

International Journal of Antimicrobial Agents, 2017
The aim of this study was to determine the prevalence and transmission mechanism(s) of mcr-1 in the gut flora of children. Faecal samples (n = 173) were obtained from non-diarrhoea patients at the Children's Hospital of Zhejiang University (Hangzhou, China). PCR-based analysis indicated that 17 isolates from 9.8% of the samples were positive for mcr-1,
Yan-Yan, Hu, Yue-Ling, Wang, Qiao-Ling, Sun, Zi-Xian, Huang, Han-Yu, Wang, Rong, Zhang, Gong-Xiang, Chen   +6 more
openaire   +2 more sources

Polymyxin Resistance Mechanisms: From Intrinsic Resistance to Mcr Genes

Recent Patents on Anti-Infective Drug Discovery, 2019
The global spread of carbapenemase-encoding genes among Gram-negative nosocomial pathogens has led to the revival of polymyxins. Colistin and polymyxin B, despite their serious adverse effects, have become last resort treatment options for multi- or even extensively-drug-resistant bacterial infections due to Klebsiella pneumoniae, Acinetobacter ...
Georgios, Meletis, Lemonia, Skoura
openaire   +2 more sources