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Plasmid-mediated colistin-resistance genes: mcr
Trends in MicrobiologyColistin is regarded as a last-line drug against serious infections caused by multidrug-resistant Gram-negative bacterial pathogens. Therefore, the emergence of mobile colistin resistance (mcr) genes has attracted global concern and led to policy changes for the use of colistin in food animals across many countries.
Jian-Hua Liu +2 more
exaly +3 more sources
Rapid Polymyxin NP test for the detection of polymyxin resistance mediated by the mcr-1/mcr-2 genes [PDF]
Diagnostic Microbiology and Infectious Disease, 2018 The Rapid Polymyxin NP test has been recently developed to rapidly detect polymyxin resistance in Enterobacteriaceae. Here we evaluated this test for detecting MCR-1/MCR-2-producing Enterobacteriaceae using a collection of 70 non-redundant strains either recovered from the environment, animals, or humans.
Laurent Poirel +2 more
exaly +6 more sources
Archives of Microbiology, 2020
Multidrug-resistant bacteria harboring different antimicrobial resistance genes (ARGs) have been detected worldwide. The association of plasmid-mediated colistin resistance genes (mcr-like) and other ARGs in bacteria isolated from animals is a huge concern worldwide.
Lucas David Rodrigues dos Santos +5 more
openaire +2 more sources
Multidrug-resistant bacteria harboring different antimicrobial resistance genes (ARGs) have been detected worldwide. The association of plasmid-mediated colistin resistance genes (mcr-like) and other ARGs in bacteria isolated from animals is a huge concern worldwide.
Lucas David Rodrigues dos Santos +5 more
openaire +2 more sources
Polymyxin Resistance Mechanisms: From Intrinsic Resistance to Mcr Genes
Recent Patents on Anti-infective Drug Discovery, 2019The global spread of carbapenemase-encoding genes among Gram-negative nosocomial pathogens has led to the revival of polymyxins. Colistin and polymyxin B, despite their serious adverse effects, have become last resort treatment options for multi- or even extensively-drug-resistant bacterial infections due to Klebsiella pneumoniae, Acinetobacter ...
Georgios Mélétis, Lemonia Skoura
exaly +3 more sources
Genetic basis of chromosomally-encoded mcr-1 gene
International Journal of Antimicrobial Agents, 2018Compared with plasmid-borne mcr-1, the occurrence of chromosomally-encoded mcr-1 is rare although it has been reported in several cases. This study aimed to investigate the genetic features of chromosomally-encoded mcr-1 among Escherichia coli strains as well as the potential genetic basis governing mobilisation of mcr-1 in bacterial chromosomes.
Ruichao, Li +7 more
openaire +2 more sources
International Journal of Antimicrobial Agents, 2020
Colistin is a last-resort drug used to treat infections caused by multidrug-resistant Gram-negative bacteria that have developed carbapenem resistance. Emergence and rapid dissemination of the nine plasmid-mediated mobile colistin resistance genes (mcr-1 to mcr-9) has led to fear of pandrug-resistant infections worldwide. To date, there is only limited
Emmanuel O. Ngbede +14 more
openaire +2 more sources
Colistin is a last-resort drug used to treat infections caused by multidrug-resistant Gram-negative bacteria that have developed carbapenem resistance. Emergence and rapid dissemination of the nine plasmid-mediated mobile colistin resistance genes (mcr-1 to mcr-9) has led to fear of pandrug-resistant infections worldwide. To date, there is only limited
Emmanuel O. Ngbede +14 more
openaire +2 more sources
Impact of the colistin resistance gene mcr-1 on bacterial fitness
International Journal of Antimicrobial Agents, 2018A Klebsiella pneumoniae isolate harbouring a 217 kb IncHI2-type plasmid (pKP2442) encoding the colistin resistance gene mcr-1 was isolated from a leukaemia patient. pKP2442 was mobilised by intragenus and intergenus transconjugation from the clinical isolate to Escherichia coli J53 (transconjugation frequency 6.86 × 10-8 ± 5.57 × 10-8) and K ...
Tietgen, Manuela +6 more
openaire +3 more sources
Colistin resistance gene mcr-1 in gut flora of children
International Journal of Antimicrobial Agents, 2017The aim of this study was to determine the prevalence and transmission mechanism(s) of mcr-1 in the gut flora of children. Faecal samples (n = 173) were obtained from non-diarrhoea patients at the Children's Hospital of Zhejiang University (Hangzhou, China). PCR-based analysis indicated that 17 isolates from 9.8% of the samples were positive for mcr-1,
Yan-Yan, Hu +6 more
openaire +2 more sources
Archives of Microbiology
The mcr gene family, responsible for plasmid-mediated resistance to colistin, poses a growing threat to public health by reducing the efficacy of colistin, a critical last-resort antibiotic for multidrug-resistant Gram-negative bacteria. The mcr-1 gene, discovered in 2015, marked a significant shift in understanding colistin resistance, and subsequent ...
Muhammad Shahid, Mehmood +8 more
openaire +2 more sources
The mcr gene family, responsible for plasmid-mediated resistance to colistin, poses a growing threat to public health by reducing the efficacy of colistin, a critical last-resort antibiotic for multidrug-resistant Gram-negative bacteria. The mcr-1 gene, discovered in 2015, marked a significant shift in understanding colistin resistance, and subsequent ...
Muhammad Shahid, Mehmood +8 more
openaire +2 more sources